Research Project
Grant-in-Aid for Young Scientists (B)
This research aims to explore the unexplored nucleic acid functions and elucidate the biological functions through chemical synthesis of keto sugar type nucleic acid in which the sugar moiety is oxidized.Chemical synthesis of nucleic acids having a keto group at 2 'position was accomplished by incorporating a branched sugar nucleoside as a key precursor. The keto sugar-type nucleic acid showed a different thermal stability compared to DNA (deoxyribose) and RNA (ribose). The introduced keto group could be converted to a hydroxyl group by a reduction reaction in an aqueous solution.
All 2018
All Presentation (1 results)