| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In recent years, the periodontitis treatment of antibacterial photodynamic therapy (aPDT) has attracted attention. The current method causes cytotoxicity by reactive oxygen species (ROS) induced by photoexcitation by dye staining. I investigated aPDT used for energy metabolism of periodontal pathogenic bacteria. It was examined that the effects of aPDT using pigment used for energy metabolism of periodontal pathogenic bacteria. It was recognized that bacterial peculiar pigment was excited and produced ROS by light irradiation. It caused bactericidal effect due to oxidation damage to DNA. According to this study, it was suggested that this aPDT has less influence on the living body than the method currently used and a possibility of a treatment method with high bactericidal effect against bacteria.
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