The new malignant tumor therapeutic drug which paid its attention to localization of the antitumor protein

• Project/Area Number: 15K21455
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry; Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: MIYMOTO CHIHIRO 神奈川歯科大学, 大学院歯学研究科, 特任講師 (50633963)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: CXCL14/BRAK / VEGF-A / 口腔癌 / ケモカイン / 育薬

Outline of Final Research Achievements

This research theme pushed forward analysis for the purpose of elucidation of the action mechanism of vascularization inhibitor CXCL14/BRAK.I pushed forward analysis about combination with VEGF-A which was CXCL14/BRAK and a vascularization promotion factor, but the meaningful result was not provided.Thus, I was not able to prove that VEGF-A participated in BRAK action by this research theme.

Research Products

• [Journal Article] xpression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma. (2017)
  • Author(s): Kondo T, Ozawa S, Ikoma T, Yang XY, Kanamori K, Suzuki K, Iwabuchi H, Maehata Y, Miyamoto C, Taguchi T, Kiyono T, Kubota E, Hata RI.
  • Journal Title: Oncogenesis. Volume: 5 Pages: 7-7
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chemokine CXCL14 is a multistep tumor suppressor. (2016)
  • Author(s): Xiao-Yan Yang, Chihiro Miyamoto, Tetsu Akasaka, Kazuhito Izukuri, Yojiro Maehata, Takeharu Ikoma, Shigeyuki Ozawa, Ryu-Ichiro Hata
  • Journal Title: Journal of Oral Biosciences Volume: 58 Issue: 1 Pages: 16-22
  • DOI: 10.1016/j.job.2015.08.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Humoral response to therapeutic low-intensity pulsed ultrasound (LIPUS) treatment of rat maxillary socket after the removal of a molar tooth (2015)
  • Author(s): Kouki Hidaka, Chihiro Miyamoto, Satoko Wada-Takahashi, Makiko Saita, Akira Kawata, Ryota Kawamata, Yojiro Maehata, Masato Minabe, Shun-suke Takahashi and Yuko Mikuni-Takagaki
  • Journal Title: International Journal of Analytical Bio-Science Volume: 3 Pages: 17-24
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Scavenger of oxidative stress effective for the inhibition of angiogenesis and tumor proliferation in human head and neck squamous cell carcinoma cells by regulation gene expression of chemokines (2016)
  • Author(s): Maehata Y, Miyamoto C, Tsukinoki K
  • Organizer: Pharmacology 2016
  • Place of Presentation: London
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] Rock inhibitor fasudil suppresses growth of tumor by stimulating gene expression and secretion of CXCL14/BRAK (2016)
  • Author(s): Miyamoto C, Maehata Y
  • Organizer: Pharmacology 2016
  • Place of Presentation: London
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] ケモカインCXCL14の発現がセツキシマブ(抗上皮増殖因子受容体抗体)による腫瘍抑制活性を決定する (2016)
  • Author(s): ●陽 暁艶, 近藤 忠稚, 小澤 重幸, 生駒 丈晴, 鈴木 健司, 岩淵 博史, 前畑 洋次郎, 宮本 千央, 久保田 英朗, 畑 隆一郎
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2016-06-24
• [Presentation] Rho Kinase (ROCK) Inhibitor Fasudil Suppresses Head and Neck Squamous Carcinoma Growth by Stimulating Gene Expression and Protein Secretion of the CXCL14/BRAK (2016)
  • Author(s): Chihiro Miyamoto, Shigeyuki Ozawa, Takeharu Ikoma, kazuhito Izukuri, Ryu-Ichiro Hata, and Yojiro Maehata
  • Organizer: he 13th Asia Pacific Federation of Pharmacologist (APFP) Meeting
  • Place of Presentation: Berkeley Hotel Pratunam, Bangkok, Thailand
  • Year and Date: 2016-02-01
  • Int'l Joint Research
• [Presentation] Laser Doppler血流系を用いた抜歯モデルラットの血流測定 (2015)
  • Author(s): 日髙恒輝，宮本千央，高橋聡子，斉田牧子，河田亮，川股亮太，前畑洋次郎，三辺正 人，高橋俊介，高垣裕子
  • Organizer: 第8回日本口腔検査学会総会・学術大会
  • Place of Presentation: 神奈川歯科大学 大講堂，横須賀
  • Year and Date: 2015-10-03