| Project/Area Number |
15K21466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
Applied microbiology
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Research Collaborator |
TAKAKU Hiroaki 新潟薬科大学, 応用生命科学部, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | テロメア / ゲノム / 分裂酵母 / G0細胞 / シェルタリン / 定常期 |
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| Outline of Final Research Achievements |
The mechanism of telomere maintenance at G0 cells of Schizosaccharomyces pombe is largely unknown. The amount of the components of shelterin complex in G0 cells was reduced to about one quarter compared to proliferating cells, suggesting that the structure of telomere might be different between G0 and proliferating cells. The viability of a deletion mutant of Rap1, which are known to negatively regulate the localization of telomerase to telomere in proliferating cells, became lower and lower in G0 phase compared to that of a wild-type strain, suggesting that Rap1 plays an important role in G0 cells.
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