| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Estimating molecular mechanisms of missense mutations on a particular disease is still challenging in the research field. In this study, I analyzed disease-causing missense mutations with its positions on protein structure, especially on macromolecular structures and found a clear relationship between the disease-causing mechanisms and the mutation residue positions on the 3D structures. According to the relationship, I developed a novel method to predict the disease-causing mechanisms caused by given missense mutations.
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