Mechanism of driver mutation positive lung cancer
| Project/Area Number |
15K21525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
Tumor therapeutics
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬効評価と予測 / 分子標的治療 |
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| Outline of Final Research Achievements |
Tumor specimens from 110 patients with lung cancer recruited between July 2013 and March 2015 were analyzed. The most common genetic alterations were TP53 mutations in 42 patients, followed by EGFR mutations in 25, STK11 mutations in 12, and KRAS mutations in 10. Potentially actionable mutations were identified in 44 patients including 50% of those with adenocarcinoma and 14% of those with squamous cell carcinoma. The OS of patients with advanced or recurrent cancer who had an actionable mutation and received targeted therapy (median OS not achieved) was significantly longer than that of those with no mutation (18.1 months, P = 0.041) or of those with a mutation not so treated (6.1 months, P = 0.0027).Multiplex genomic testing was performed on formalin-fixed, paraffin-embedded tumor specimens with a success rate of -95%. Such testing can assist physicians in matching patients with approved or experimental targeted treatments.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Successful human epidermal growth receptor 2-targeted therapy beyond disease progression for extramammary Paget's disease.2016
Author(s)
Watanabe S, Takeda M, Takahama T, Iwasa T, Tsurutani J, Tanizaki J, Shimizu T, Sakai K, Wada Y, Isogai N, Nishio K, Nakagawa K.
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Journal Title
Invest New Drugs.
Volume: Feb 9
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinical application of amplicon-based next-generation sequencing to therapeutic decision making in lung cancer.2015
Author(s)
Takeda M, Sakai K, Terashima M, Kaneda H, Hayashi H, Tanaka K, Okamoto K, Takahama T, Yoshida T, Iwasa T, Shimizu T, Nonagase Y, Kudo K, Tomida S, Mitsudomi T, Saigo K, Ito A, Nakagawa K, Nishio K.
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Journal Title
Ann Oncol
Volume: 26(12)
Issue: 12
Pages: 2477-2482
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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