Development of size-tunable nanoparticles for delivering hydrophobic drugs to hypoxic areas in tumor
| Project/Area Number |
15K21534
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
Physical pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脂質-高分子複合ナノ粒子 / がん化学療法 / ナノメディシン / フィトケミカル / 疎水性薬物 / 薬物送達システム / ナノ粒子 / がん / 医療ナノ粒子 / 粒子径制御 / 化学療法 |
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| Outline of Final Research Achievements |
This study purposed to develop lipid-polymer hybrid nanoparticles (LPNs) that possess high loading efficiency of hydrophobic drugs and long blood circulation time and can deliver these drugs to hypoxic areas in tumor by tuning LPN size. Following two results were obtained. First, this study found the influence of LPN size on anti-tumor activity and drug release in optimized condition for encapsulating hydrophobic drugs. Second, using microreactors established a method to assemble ultrasmall and monodisperse LPNs. These results serve as a fundamental technology for application to in vivo experiments and clinical settings.
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Report
(4 results)
Research Products
(6 results)
