| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
This study purposed to develop lipid-polymer hybrid nanoparticles (LPNs) that possess high loading efficiency of hydrophobic drugs and long blood circulation time and can deliver these drugs to hypoxic areas in tumor by tuning LPN size. Following two results were obtained. First, this study found the influence of LPN size on anti-tumor activity and drug release in optimized condition for encapsulating hydrophobic drugs. Second, using microreactors established a method to assemble ultrasmall and monodisperse LPNs. These results serve as a fundamental technology for application to in vivo experiments and clinical settings.
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