Therapeutic strategy focusing on extracellular factors on delayed recovery of disuse muscle atrophy by aging
| Project/Area Number |
15K21540
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
Applied health science
|
|---|
| Research Institution | Osaka University of Human Sciences (2016-2017)
Takarazuka University of Medical and Health Care (2015) |
|---|
Principal Investigator |
Kanazawa Yuji 大阪人間科学大学, 人間科学部, 講師 (60620656)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 骨格筋 / 老化 / 廃用性筋萎縮 / 線維芽細胞 / 後肢非荷重 / 再荷重 / Collagen IV / 基底板 / 細胞外マトリックス |
|---|
| Outline of Final Research Achievements |
In this study, we show that, in the older rats, reloading after disuse atrophy, causes the damage of the muscle fibers and the basement membrane (BM) that structurally support the muscle fibers. After reloading, ectopic immunoreactivity of collagen IV, a major component of the BM, remained mostly associated with the necrotic appearance, suggesting that the older rats were impaired with the ability of repairing the damaged BM. Further, after reloading, the older rats did not show a significant alteration, although the young rats showed clear response of collagen IV related genes. Taken together, our findings suggest that the atrophic muscle fibers of the older rats induced by unloading were vulnerable to the weight loading, and that attenuated reactivity of the BM-synthesizing fibroblast to gravity contributes to the fragility of muscle fibers in the older rats. It is clear that prevention of senescence in fibroblast is an important therapeutic strategy for muscle recovery.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 老化と骨格筋2016
Author(s)
金澤佑治
Organizer
第14回大阪人間科学大学学術研究懇談会
Place of Presentation
大阪人間科学大学（大阪）
Year and Date
2016-12-01
Related Report
-
-
-
-
