| Project/Area Number |
15K21542
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
Applied pharmacology
|
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| Research Institution | International University of Health and Welfare (2016-2017)
Kawasaki Medical School (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 喫煙 / アルコール依存症 / L 型カルシウムチャネル / ニコチン曝露 / アルコール摂取 / 飲酒欲求 / 細胞内カルシウム動態 |
|---|
| Outline of Final Research Achievements |
Nicotine and Ethanol (EtOH) have been frequently reported to be co-abused in humans. It is reported that smoker are more likely to be diagnosed with alcoholism than non-smokers. In this study, we investigated the involvement of L-type Cav1 channels in EtOH-induced place preference and EtOH intake using animals chronically treated with nicotine in adolescence. These results suggest that the facilitated EtOH-induced place preference and EtOH intake, when nicotine exposure history existed in adolescence, is due to up-regulated L-type Cav1.2 channels in dopamine D1 receptor-expressing nucleus accumbencs neurons.
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