| Project/Area Number |
15K21555
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
Gastroenterology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 肝細胞癌 / 血管新生 / 血管新生抑制治療 / AMPK / 血管新生阻害剤 / エネルギー代謝 / 低酸素誘導因子 / 耐性 / ＡＭＰＫ |
|---|
| Outline of Final Research Achievements |
The purpose of this study is to clarify whether energy metabolism is related to resistance for anti-angiogenic therapy. It is generally known that AMPK was activated when the cells falled into starved condition. We have found that AMPK was activated even in cancer cells by anti-angiogenic therapy. To know the function of tumor AMPK in anti-angiogenic therapy, we have generated AMPK deleted hepatoma cell lines. And we have performed in vitro and in vivo experiments using these cell lines. However, AMPK did not correlate with resistance for anti-angiogenic therapy. In contrast, inhibition of hypoxia inducible factor (HIF) showed significant anti-tumor effect for hepatocellular carcinoma.
|
