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Analysis of aging and carcinogenesis mechanism using replication incompletion model mice

Research Project

Project/Area Number 15K21565
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Molecular biology
Risk sciences of radiation and chemicals
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

KOHZAKI Masaoki  産業医科大学, 産業生態科学研究所, 助教 (90717977)

Research Collaborator MIYATA Hironori  
OHTSUKA Masato  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsDNA複製 / 細胞周期チェックポイント / トランスジェニックマウス / コンディショナルノックアウト / 発がん / 老化 / 複製 / 細胞周期チェックポイ / マウスモデル / Cre-loxP / 抗がん剤耐性 / ノックアウト / p53
Outline of Final Research Achievements

Inappropriate replication completion may cause genome instability, a characteristic of almost all human cancers. However, the direct relationship between incompletion of replication and cancer remains largely unknown. Here we sought to establish replication completion-related X gene knockout mice to address the hypothesis and confirm the phenotypes. Although we established gene X knockout mice as a mouse model for replication incompletion, we found that gene X is partially essential for viability and the viability depends on mouse strains. It was practically difficult for us to conduct several experiments with these mice. Hence, we changed strategy to make conventional conditional X gene knockout mice. At present, we obtained the floxed X gene mice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(8 results)

All 2017 Other

All Int'l Joint Research Journal Article Presentation Remarks Patent(Industrial Property Rights)

  • [Int'l Joint Research] University of Geneva(Switzerland)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Geneva(Switzerland)

    • Related Report
      2016 Research-status Report
  • [Journal Article] A Survey about the Radiation Effects and A Health Survey of Fukushima Inhabitants after the Fukushima Daiichi Nuclear Power Plant Accident2017

    • Author(s)
      Okazaki R, Ohga K, Yoko-O M, Kohzaki M.
    • Journal Title

      J UOEH

      Volume: 39 Pages: 277-290

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Role of DNA repair pathways in cancer progression2017

    • Author(s)
      Kohzaki M.
    • Organizer
      GDN genome stability
    • Related Report
      2017 Annual Research Report
  • [Presentation] 今、何が放射線生物学に求められているのか?2017

    • Author(s)
      Kohzaki M.
    • Organizer
      大阪放射線生物学ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線誘導C57BL/6マウス腫瘍の発生閾値周辺領域解析2017

    • Author(s)
      香﨑正宙、大津山彰、阿部利明、孫略、馬田敏幸、盛武敬、岡﨑龍史
    • Organizer
      第57回放射線影響懇話会
    • Related Report
      2017 Annual Research Report
  • [Remarks] Thanos Halazonetis Lab - molbio.unige.ch

    • URL

      http://www.molbio.unige.ch/fra/research_groups/halazonetis/lab

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 誤りがちDNA修復経路の抑制による がんの治療2017

    • Inventor(s)
      M. Kohzaki
    • Industrial Property Rights Holder
      M. Kohzaki
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-138916
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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