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Enhancement of memory consolidation based on neuroscientific measures

Research Project

Project/Area Number 15K21602
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental psychology
Cognitive science
Research InstitutionWaseda University (2016)
National Institute for Physiological Sciences (2015)

Principal Investigator

Sugawara Sho  早稲田大学, 理工学術院, 日本学術振興会特別研究員 (80723428)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords機能的磁気共鳴画像 / 運動学習 / 記憶定着 / 記憶痕跡 / 運動技能学習 / 機能的磁気共鳴画像法 / 脳機能イメージング
Outline of Final Research Achievements

Memory is formed through two distinct processes over time. One is encoding which works when people learn novel materials, the other is consolidation occurred after the encoding. To develop the application for the enhancement of the memory consolidation using a neuroscientific index, the purpose of this project was to identify the encoding-related neuronal activity which predicts the subsequent memory consolidation. By measuring functional magnetic resonance imaging during the sequential motor learning, we found that primary motor area holds the motor memory about the sequential motor skill during encoding, and that the declarative memory system including hippocampus has a critical role for the motor memory consolidation. Future study should develop the method for enhancing memory consolidation using the present findings.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Increased frequency of social interaction is associated with enjoyment and reward system activation2016

    • Author(s)
      Hiroaki Kawamichi, Sho K. Sugawara, Yuki H. Hamano, Kai Makita, Takanori Kochiyama, and Sadato N
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep24561

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Helping behavior induced by empathetic concern attenuates anterior cingulate activation in response to others’ distress.2016

    • Author(s)
      Kawamichi H, Yoshihara K, Sugawara SK, Matsunaga M, Makita K, Hamano YH, Tanabe HC, Sadato N
    • Journal Title

      Social Neuroscience

      Volume: 11 Issue: 2 Pages: 109-122

    • DOI

      10.1080/17470919.2015.1049709

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 系列運動技能の定着に対する宣言的記憶システムの関与2017

    • Author(s)
      菅原 翔・濱野友希・定藤規弘
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト系列運動学習における皮質-皮質下構造の役割 機能的MRI研究2017

    • Author(s)
      濱野友希・菅原 翔・定藤規弘
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都大学百周年時計台記念館
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Reactivation of declarative memory system is essential for the enhancement of the sequential motor skill.2016

    • Author(s)
      Sugawara SK, Hamano YH, Sadato N
    • Organizer
      Society for Neuroscience's 46st Annual Meeting
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic change of the parieto-premotor network during early motor sequence learning: an fMRI study.2016

    • Author(s)
      Hamano YH, Sugawara SK, Sadato N
    • Organizer
      Society for Neuroscience's 46st Annual Meeting
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 一次運動野を中心とした皮質ネットワークでの系列運動技能の記憶保持2016

    • Author(s)
      菅原 翔・濱野友希・定藤規弘
    • Organizer
      第10回Motor Control研究会
    • Place of Presentation
      慶應大学日吉キャンパス
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] M1-centered cortical network holds the learned representations during early motor sequence learning: an fMRI study.2016

    • Author(s)
      Hamano Y, Sugawara SK, Sadato N
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combined speed- and accuracy-focused training prevents offline performance improvements in sequential motor skill2015

    • Author(s)
      Sho K. Sugawara, Yuki H. Hamano, Naoya Aoki, Hideaki Yamzaki-Kindaichi, Takaaki Yoshimoto, and Norihiro Sadato
    • Organizer
      Society for Neuroscience's 45st Annual Meeting
    • Place of Presentation
      McCormick Place, Cicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The cortico-striatal network holds the memory of the sequential motor skill during the early training stage2015

    • Author(s)
      Yuki H. Hamano, Sho K. Sugawara, Hideaki Yamazaki-Kindaich, Naoya Aoki, Takaaki Yoshimoto, and Norihiro Sadato
    • Organizer
      Society for Neuroscience's 45st Annual Meeting
    • Place of Presentation
      McCormick Place, Cicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Both primary motor area and striatum hold the memory of the sequential motor skill during the early training stage2015

    • Author(s)
      Yuki H. Hamano, Sho K. Sugawara, Hideaki Yamazaki-Kindaich, Naoya Aoki, Takaaki Yoshimoto, and Norihiro Sadato
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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