The role of extracellular matrix in cortical neuronal circuit remodeling in chronic pain
| Project/Area Number |
15K21603
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
Basic / Social brain science
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
Eto Kei 生理学研究所, 基盤神経科学研究領域, 助教 (30545257)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性疼痛 / 一次体性感覚野 / アストロサイト / 2光子顕微鏡 |
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| Outline of Final Research Achievements |
In the chronic pain, which is induced by peripheral nerve injury, the cortical neuronal circuit reorganizes in the primary somatosensory cortex (S1), which in turn cause chronic pain-like behavior. The aim of this study is to clarify whether extracellular matrix and astrocytes contribute to neuronal circuit remodeling observed in the S1 in chronic pain. In the present study, we elucidated that astrocytes are involved in enhancement of neuronal plasticity in the S1 after nerve injury. Moreover, enhanced neuronal inputs can induce cortical neuronal circuit remodeling with astrocytic activation, leading to chronic pain-like behavior.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section2015
Author(s)
1.N. Ieda, K. Hishikawa, K. Eto, K. Kitamura, M. Kawaguchi, T. Suzuki, K. Fukuhara, N. Miyata, T. Furuta, J. Nabekura, H. Nakagawa
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 25
Issue: 16
Pages: 3172-3175
DOI
Related Report
Peer Reviewed / Open Access
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