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The role of primary somatosensory cortex in chronic pain

Research Project

Project/Area Number 15K21604
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Pain science
Research InstitutionUniversity of Fukui

Principal Investigator

Ishikawa Tatsuya  福井大学, 学術研究院医学系部門, 特命助教 (00750209)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経回路再編 / ニューロン・グリア連関 / 慢性疼痛 / ミラーイメージペイン / in vivo 2光子イメージング / 免疫電子顕微鏡法 / 凍結割断レプリカ法 / 一次体性感覚野 / In vivo イメージング / in vivo イメージング
Outline of Final Research Achievements

Some chronic pain patients have an abnormal pain sensation in contralateral limb to injury, which is called mirror image pain. Since synaptic remodeling in the primary somatosensory cortex (S1) has critical roles in induction of chronic pain, cortical reorganization in the S1 ipsilateral to injured limb may contribute to mirror image pain. However, contribution of cortical cells in the S1 in mirror image pain remain completely unknown.
In the present study, we found that inhibitory neuronal activities and astrocytic activities increased in the S1, while excitatory neuronal function decreased. Disinhibition of ipsilateral S1 induced by chronic application of GABAA receptor antagonist caused enhancement of neuronal activities, synaptic remodeling and chronic pain, and these are blocked by inhibition of astrocytic activities. Therefore, present results indicate that disinhibition of ipsilateral S1 to injured limb may contribute to induction of mirror image pain with synaptic remodeling.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Microglial contact prevents excess depolarization and rescues neurons from excitotoxity2016

    • Author(s)
      Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, Eto K, Ishikawa T, Moorhouse AJ, Strassman AM, Nabekura J
    • Journal Title

      eNeuro

      Volume: 0004 Issue: 3 Pages: 0004-16

    • DOI

      10.1523/eneuro.0004-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.2016

    • Author(s)
      Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J.
    • Journal Title

      J Clin Invest

      Volume: 126(5) Issue: 5 Pages: 1983-1997

    • DOI

      10.1172/jci82859

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Early-life stress increases the motility of microglia in adulthood.2014

    • Author(s)
      Takatsuru Y, Nabekura J, Ishikawa T, Kohsaka S, Koibuchi N.
    • Journal Title

      J Physiol Sci.

      Volume: 65 Issue: 2 Pages: 187-194

    • DOI

      10.1007/s12576-015-0361-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Contribution of inter-regional regulation of primary somatosensory cortical functional change in chronic pain.2017

    • Author(s)
      Eto Kei, Ishikawa Tatsuya, Ishibashi Hitoshi, Nabekura Junnichi
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of primary somatosensory cortex in chronic pain2015

    • Author(s)
      Tatsuya Ishikawa, Kei Eto, Hitoshi Ishibashi, Junichi Nabekura
    • Organizer
      第8回アジア・オセアニア生理学会連合(FAOPS) 2015年大会
    • Place of Presentation
      Centara Gr and & Bangkok Convention Centre(Thailand))
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性疼痛発症時における大脳皮質一次体性感覚野の役割2015

    • Author(s)
      石川達也、江藤圭、石橋仁、鍋倉淳一
    • Organizer
      日本解剖学会第75回中部支部集会
    • Place of Presentation
      福井大学松岡キャンパス(福井県)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] The role of primary somatosensory cortex in chronic pain.2015

    • Author(s)
      Tatsuya Ishikawa, Kei Eto, Hitoshi Ishibashi, Junichi Nabekura
    • Organizer
      第38回日本神経科学会大会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場(兵庫県)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Remarks] 福井大学 医学部 脳形態機能学(解剖2)研究室

    • URL

      http://kaibou2.med.lab.u-fukui.ac.jp/ja/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 生理学研究所 基盤神経科学領域 生体恒常性発達研究部門

    • URL

      http://www.nips.ac.jp/hsdev/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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