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The molecular mechanism of hypovitaminosis E which is a factor in the risk of peripartum diseases: Focusing on the mammary gland and liver

Research Project

Project/Area Number 15K21620
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Animal production science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

HAGA Satoshi  国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門 草地利用研究領域, 主任研究員 (90442748)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords乳牛 / 周産期疾病 / 乳腺 / 肝臓 / 初乳 / ビタミンE / 分娩性ストレス / 分娩ストレス / 肝機能 / 高泌乳牛 / ビタミンE
Outline of Final Research Achievements

In dairy cows, the majority of the production diseases occur around calving or during early lactation. The management of dairy farm is made worse by the cost. Peripartum hypovitaminosis E is a factor of this risk. The aim of this study was to elucidate of the molecular mechanism of hypovitaminosis E for the reducing the risk of peripartum diseases. In fact, focusing on the mammary gland and liver, we made clear the gene expression properties of αTTP, Afamin, and TAP, which are related with hypovitaminosis E process in peripartum high-yeild dairy cows. The results of this study could help in the developmental work to reduce the risk of the hypovitaminosis E and the production diseases in dairy cows.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] ウシ組織におけるα-トコフェロール体内動態関連遺伝子の発現特性に関する研究2017

    • Author(s)
      芳賀聡、中野美和、宮地慎、石崎宏、松山裕城、鈴木裕、北山峻、小林洋介、加藤和雄、盧尚建
    • Journal Title

      栄養生理研究会報

      Volume: 61 Pages: 9-19

    • NAID

      40021128800

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] STUDY ON THE DISPOSITION OF VITAMIN E AND EXPRESSION OF α-TOCOPHEROL-RELATED GENES DURING WEANING AND PERIPARTUM IN CATTLE2016

    • Author(s)
      芳賀聡
    • Journal Title

      東北大学博士学位論文

      Volume: - Pages: 1-140

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ウシ組織におけるα-トコフェロール体内動態関連遺伝子の発現特性に関する研究2017

    • Author(s)
      芳賀聡
    • Organizer
      家畜栄養生理研究会平成29年度春季集談会
    • Place of Presentation
      京都大学(京都府・宇治市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Changes of the hepatic expression of α-tocopherol-related genes in relation to the hypovitaminosis E around calving in dairy cows2016

    • Author(s)
      芳賀聡、中野美和、宮地慎、石崎宏、盧尚建
    • Organizer
      2016 17th AAAP Animal Science Congress
    • Place of Presentation
      九州産業大学(福岡県・福岡市)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 初乳生産期の乳腺におけるGlucose・BHBA取込率および輸送体発現2015

    • Author(s)
      芳賀聡、中野美和、宮地慎、松山裕城、加藤和雄、盧尚建
    • Organizer
      日本畜産学会第120回大会
    • Place of Presentation
      酪農学園大学(北海道・江別市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Book] 畜産の研究第69巻12号:反芻動物の生産に関する最近の研究動向(4)泌乳生理機能と乳量制御2015

    • Author(s)
      芳賀聡、鈴木裕、加藤大地、加藤和雄、盧尚建
    • Publisher
      養賢堂
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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