| Project/Area Number |
15K21621
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Urology
Radiation science
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
Nozaki Satoshi 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (10419707)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 前立腺癌 / PET / LAT1 |
|---|
| Outline of Final Research Achievements |
We have already developed novel PET tracer [18F]CTP0006 which targeted amino acid transporter LAT1 for detecting malignant cancer. We performed basic research to evaluate the usefulness of this compound for detecting prostate cancer. We firstly checked the protein expression level of LAT1 in prostate cancer cell lines and tumor tissues derived from tumor-bearing mice. At these experiments, high expression levels of LAT1 in these samples were confirmed. Moreover, we also performed the development of animal model for prostate cancer by orthotopic transplantation. However, these experiments were failed because survival rate and tumor implantation rate were too low. The cause for the failure requires further investigation.
|
