Research on regulatory mechanism for oscillation and switch-like response of NF-kB
| Project/Area Number |
15K21624
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
System genome science
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| Research Institution | University of Miyazaki (2016-2017)
Institute of Physical and Chemical Research (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | シグナル伝達 / 数理モデリング / シミュレーション / NF-kB / システム生物学 / モデリング |
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| Outline of Final Research Achievements |
Nuclear factor kappa B (NF-kB) is a transcription factor and is important for cell fate decision. The regulatory mechanism of NF-kB activation at molecular level is still unclear. We developed a mathematical model for NF-kB signal transduction system and focus on oscillatory behavior and switch-like response of NF-kB activity. Furthermore, we validated the results by biological experiments. The numerical and theoretical analysis showed that the mechanism of oscillatory behavior and switch-like response of NF-kB activity is not same but their behaviors can be interpolated by balance among amounts of molecules and reaction rates with respect to the activation. Our experiments supported the results.
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Report
(4 results)
Research Products
(12 results)
