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Development of the artificial body control system using the optical neurocommunicator

Research Project

Project/Area Number 15K21627
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Brain biometrics
Medical systems
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

KOBAYASHI Takuma  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (80582288)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords脳内埋植型デバイス / Optic Neurocommunicator / 三次元培養 / 光プローブ / artificial body / 脳機能光計測 / 脳機能光制御 / 光双方向神経活動伝達 / スキルラーニング / goal directed behavior / brain machine interface / 装着型デバイス / 蛍光イメージング / optogenetics / transgenic mouse / neurological prosthesis / motor skill learning / 行動予測 / wearable instrument / Ca2+ imaging / 光遺伝学 / 遺伝子改変マウス / 身体補綴装具
Outline of Final Research Achievements

Even if it is difficult to acquire the comprehensions from the acquaintances of scientist, the neuroprosthetics for the challenged should be studied. Unfortunately there is almost no neurological engineering department in our country, and the interdisciplinary neuroprosthetics is unfamiliar academic disciplinesa. However, since 2009, research on the optical neurocommunicator has been intermittently continued with the sympathetic and visionary supporters and the Grants-in-Aid for Scientific Research (KAKENHI). Thanks to that, the several types of wearable instruments for neuroimaging and optogenetics were newly invented, and the artificial body control system was structured using the optical neurocommunicator which applied to the brain less-invasively in combination. And actually, that system was demonstrated to work by using the animals basically. Although there is room for improvement unsurprisingly, the technology will contribute as a new prosthetic method for human in the future.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 Other

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Remarks (2 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 2 results)

  • [Journal Article] Implantable microimaging device for observing brain activities of rodents2017

    • Author(s)
      Jun Ohta, Yasumi Ohta, Hiroaki Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Makito Haruta, Takuma Kobayashi,Yasemin M. Akay, Metin Akay
    • Journal Title

      Proceedings of the IEEE

      Volume: 105 Issue: 1 Pages: 158-166

    • DOI

      10.1109/jproc.2016.2585585

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] "Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca(2+) fluoroimaging".2016

    • Author(s)
      Kobayashi T, Haruta M, Sasagawa K, Matsumata M, Eizumi K, Kitsumoto C, Motoyama M, Maezawa Y, Ohta Y, Noda T, Tokuda T, Ishikawa Y, Ohta J.
    • Journal Title

      Sci Rep.

      Volume: 16 Issue: 1 Pages: 1-13

    • DOI

      10.1038/srep21247

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 社会的闘争の勝敗は手綱核によって決定される2016

    • Author(s)
      松股 美穂, 小林 琢磨, 平尾 顕三, Tanvir Islam, 小林 祐樹, Arthur Huang, Tomas J. McHugh, 糸原 重美, 岡本 仁
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] The optogenetic activation of the ventral medial habenula to interpeduncular nucleus pathway makes mice timid in social conflicts2016

    • Author(s)
      Miho Matsumata,Takuma Kobayashi,Kenzo Hirao,Arthur Huang,Megumi Kobayashi,Kawori Eizumi,Thomas J McHugh,Hitoshi Okamoto
    • Organizer
      第39回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Remarks] 広報:「生体内に埋植可能なウェアラブル光プローブ」(2016年10月17日)

    • URL

      http://www.riken.jp/outreach/ip/08413/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 広報:「生体内の細胞の活動によって操縦できる外部装置およびその制御システム」(2016年10月25日

    • URL

      http://www.riken.jp/outreach/ip/08438/

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 撮像装置、及び、生体情報取得装置2017

    • Inventor(s)
      小林琢磨、岡本仁、飯野裕行、大井一成
    • Industrial Property Rights Holder
      小林琢磨、岡本仁、飯野裕行、大井一成
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-03
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 発光装置、発光システム、及び、発光装置の製造方法2016

    • Inventor(s)
      小林琢磨、松股美穂、岡本仁
    • Industrial Property Rights Holder
      小林琢磨、松股美穂、岡本仁
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 撮像装置、及び、生体情報取得装置2016

    • Inventor(s)
      小林琢磨、岡本仁、飯野裕行、大井一成
    • Industrial Property Rights Holder
      小林琢磨、岡本仁、飯野裕行、大井一成
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-042550
    • Filing Date
      2016-03-04
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 発光装置、発光システム、及び、発光装置の製造方法2015

    • Inventor(s)
      小林琢磨、松股美穂、岡本仁
    • Industrial Property Rights Holder
      小林琢磨、松股美穂、岡本仁
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-148172
    • Filing Date
      2015-07-27
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 撮像装置、及び、生体情報取得装置2015

    • Inventor(s)
      小林琢磨、岡本仁
    • Industrial Property Rights Holder
      小林琢磨、岡本仁
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-171391
    • Filing Date
      2015-08-31
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 制御装置、制御システム、操縦装置及び移動体2015

    • Inventor(s)
      小林琢磨、岡本仁
    • Industrial Property Rights Holder
      小林琢磨、岡本仁
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-178940
    • Filing Date
      2015-09-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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