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Study on the developmental basis behind the evolutionary changes of musculoskeletal connections in vertebrates

Research Project

Project/Area Number 15K21628
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Stratigraphy/Paleontology
General anatomy (including histology/embryology)
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Hirasawa Tatsuya  国立研究開発法人理化学研究所, 倉谷形態進化研究室, 研究員 (60585793)

Research Collaborator FUJIMOTO Satoko  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords進化 / 発生 / 脊椎動物 / 筋 / 腱 / 化石 / 脊椎動物進化 / 進化発生学 / 古生物学 / 筋骨格系
Outline of Final Research Achievements

The development of musculoskeletal connections in vertebrates and its relationship with the evolutionary changes were studied. We analyzed the developmental process of tendons in the forelimbs of four tetrapod taxa, based on Scx expression patterns, and built a foundation of future researches on the relationship between developmental variability and evolvability. In addition, as an unexpected result, we found that in the evolution towards the turtles, the pectoralis muscle released the connection with the skeletal system and made a connection with the dermis covering the plastron.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] The neural crest and evolution of the head/trunk interface in vertebrates2018

    • Author(s)
      Kuratani S, Kusakabe R, Hirasawa T
    • Journal Title

      Developmental Biology

      Volume: in press Pages: 30922-30923

    • DOI

      10.1016/j.ydbio.2018.01.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 1.Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods.2017

    • Author(s)
      Matsubara Y., Hirasawa T., Egawa S., Hattori A., Suganuma T., Kohara Y., Nagai T., Tamura K., Kuratani S., Kuroiwa A., Suzuki T
    • Journal Title

      Nature Ecology and Evolution

      Volume: 1 Issue: 9 Pages: 1392-1399

    • DOI

      10.1038/s41559-017-0247-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outflow tract septation and the aortic arch system in reptiles: lessons for understanding the mammalian heart2017

    • Author(s)
      Poelmann RE, Gittenberger-de Groot AC, Biermans MWM, Dolfing AI, Jagessar A, van Hattum S, Hoogenboom A, Wisse LJ, Vicente-Steijn R, de Bakker MAG, Vonk FJ, Hirasawa T, Kuratani S, Richardson MK
    • Journal Title

      EvoDevo

      Volume: 8 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s13227-017-0072-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] News & Views: Getting the measure of a monster.2016

    • Author(s)
      Kuratani, S., and Hirasawa, T
    • Journal Title

      Nature

      Volume: 532 Issue: 7600 Pages: 447-448

    • DOI

      10.1038/nature17885

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Palaeospondylus as a primitive hagfish.2016

    • Author(s)
      Hirasawa, T., Oisi, Y., and Kuratani, S.
    • Journal Title

      Zool. Lett.

      Volume: 2 Issue: 1 Pages: 20-20

    • DOI

      10.1186/s40851-016-0057-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] On the vagal cardiac nerves, with special reference to the early evolution of the head-trunk-interface.2016

    • Author(s)
      Higashiyama, H., Hirasawa, T., Oisi, Y., Sugahara, F., Hyodo, S., Kanai, Y., and Kuratani, S.
    • Journal Title

      J. Morphol.

      Volume: 277 Issue: 9 Pages: 1146-1158

    • DOI

      10.1002/jmor.20563

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expansion of the neck reconstituted the shoulder-diaphragm in amniote evolution2016

    • Author(s)
      Hirasawa T, Fujimoto S, Kuratani S
    • Journal Title

      Development, Growth & Differentiation

      Volume: 58 Issue: 1 Pages: 143-153

    • DOI

      10.1111/dgd.12243

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental mechanisms of the tympanic membrane in mammals and non-mammalian amniotes2016

    • Author(s)
      Takechi, M., Kitazawa, T., Hirasawa, T., Hirai, T., Iseki, S., Kurihara, H., Kuratani, S.
    • Journal Title

      Congenital Anomalies

      Volume: 56 Issue: 1 Pages: 12-17

    • DOI

      10.1111/cga.12132

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparative analysis of pleurodiran and cryptodiran turtle embryos depicts the molecular ground pattern of the turtle carapacial ridge2015

    • Author(s)
      Pascual-Anaya J, Hirasawa T, Sato I, Kuraku S, Kuratani S
    • Journal Title

      International Journal of Developmental Biology

      Volume: 58 Issue: 10-11-12 Pages: 743-750

    • DOI

      10.1387/ijdb.140296jp

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.2015

    • Author(s)
      Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux-Neme N, Kume H, Maeda K, Hirai T, Miyagawa-Tomita S, Kurihara Y, Hitomi J, Levi G, Kuratani S, Kurihara H
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6853-6853

    • DOI

      10.1038/ncomms7853

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Evolutionary developmental perspectives on the variability of limb muscle connections2018

    • Author(s)
      Hirasawa T
    • Organizer
      1st AsiaEvo Conference (Shenzhen, China)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolutionary origin of the turtle shell accompanied with the loss of the sternum2018

    • Author(s)
      Hirasawa T, Kuratani S
    • Organizer
      6th Turtle Evolution Symposium (Tokyo)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mode in Evolution of Tetrapod Musculoskeletal Systems: A case Study of an Evolutionary Breakthrough, the Diaphragm2017

    • Author(s)
      Hirasawa T
    • Organizer
      Zoological Letters Symposium: Early Evolution and Diversity of Vertebrates
    • Place of Presentation
      理化学研究所多細胞システム形成研究センター(兵庫県・神戸市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolutionary origin of the diaphragm2016

    • Author(s)
      Hirasawa T, Fujimoto S, Kuratani S
    • Organizer
      76th Annual Meeting, Society of Vertebrate Paleontology
    • Place of Presentation
      Salt Lake City, UT
    • Year and Date
      2016-10-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Developmental basis behind the evolutionary origin of the diaphragm2016

    • Author(s)
      Hirasawa T, Fujimoto S, Kuratani S
    • Organizer
      11th International Congress of Vertebrate Morphology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 古生物学と発生学をつなぐ2015

    • Author(s)
      平沢達矢
    • Organizer
      京都大学大学院理学系研究科生物科学専攻生物多様性コロキウム
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 手の百科事典2017

    • Author(s)
      バイオメカニズム学会(「手の起源」、「両生類」、「恐竜と鳥の指骨の相同」を担当)
    • Total Pages
      608
    • Publisher
      朝倉書店
    • ISBN
      9784254102673
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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