Comprehensive identification of microRNAs that control atopic dermatitis using a gene regulatory network
| Project/Area Number |
15K21631
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
Dermatology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kawakami Eiryo 国立研究開発法人理化学研究所, 科学技術ハブ推進本部, 上級研究員 (30725338)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝子制御ネットワーク / 転写因子 / マイクロRNA / アトピー性皮膚炎 / Gene set enrichment解析 |
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| Outline of Final Research Achievements |
The greatest result of this research is the development of wPGSA (weighted Parametric Gene Set Analysis) method which comprehensively predicts control factors from gene expression data taking stochastic control relationship into account (Kawakami et al. Nucleic Acids Research 2016). Prediction of transcriptional regulators by the wPGSA method is not limited to atopic dermatitis, but it has revealed the involvement of regulatory factors that have not been known until now in many life phenomena / diseases, and we are conducting joint research with more than 20 experimental groups.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways2016
Author(s)
Eiryo Kawakami, Vivek K Singh, Kazuko Matsubara, Takashi Ishii, Yukiko Matsuoka, Takeshi Hase,Priya Kulkarni, Kenaz Siddiqui, Janhavi Kodilkar, Nitisha Danve, Indhupriya Subramanian, Manami Katoh, Yuki Shimizu-Yoshida, Samik Ghosh, Abhay Jere & Hiroaki Kitano
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Journal Title
npj Systems Biology and Applications
Volume: 2
Issue: 1
Pages: 15018-15018
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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