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Role of TSLP in skin inflammation at chronic stage

Research Project

Project/Area Number 15K21649
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Dermatology
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

KITAJIMA MASAYUKI  国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (00401000)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords慢性炎症 / アレルギー性皮膚炎 / TSLP
Outline of Final Research Achievements

The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic inflammation in humans and mice. However, its role in chronic skin inflammation has not been elucidated. To understand the role of TSLP in chronic phase of skin inflammation, we established novel skin inflammation mouse models utilizing TSLP receptor (TSLPR)-deficient mice and conditional TSLPR-deficient mice in the current study. Results from these models revealed that TSLP has pivotal roles in skin inflammation in chronic stage. In addition, we found that dendritic cells and T cells are the target of TSLP in chronic skin inflammation by using cell type specific conditional TSLPR-deficient mice. Additionally, analysis from TSLP-reporter mice indicated that dendritic cells and monocytoid cells produced TSLP in chronic inflamed skin region. Collectively, our current results proved the essential requirement of TSLP in chronic skin inflammation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Benaroya Research Institute(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Baculovirus directly activates murine NK cells via TLR92017

    • Author(s)
      Moriyama, T., Suzuki, T., Chang, Mo., Kitajima, M., Takaku, H.
    • Journal Title

      The Journal of Cancer Gene and Cellular Therapies

      Volume: - Issue: 4 Pages: 175-179

    • DOI

      10.1038/cgt.2017.2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Histone Methyltransferase ESET Is Critical for T Cell Development2016

    • Author(s)
      Takikita, S. Muro, R. Takai, T. Otsubo, T. Kawamura, Y. I. Dohi, T. Oda, H. Kitajima, M. Oshima, K. Hattori, M. Endo, T. A. Toyoda, T. Weis, J. Shinkai, Y. Suzuki, H.
    • Journal Title

      J Immunol

      Volume: 197 Issue: 6 Pages: 2269-2279

    • DOI

      10.4049/jimmunol.1502486

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Baculovirus infection of human monocyte-derived dendritic cells restricts HIV-1 replication.2015

    • Author(s)
      Oo Chang, M., Suzuki, T., Kitajima, M., Takaku, H.
    • Journal Title

      AID Res Hum Retrovirues

      Volume: 10 Issue: 10 Pages: 1023-1031

    • DOI

      10.1089/aid.2015.0060

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] NAD(P)H:quinone oxidoreductase (Nqo1) regulates irritant contact dermatitis through homeostasis of epidermal γδ T cells.2016

    • Author(s)
      M Kitajima, A Kimura, H Suzuki
    • Organizer
      第45回 日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] NAD(P)H:quinone oxidoreductase (Nqo1) regulates irritant contact dermatitis through homeostasis of epidermal γδ T cells.2016

    • Author(s)
      M Kitajima, A Kimura, H Suzuki
    • Organizer
      Immunology 2016, The American Association of Immunologists Annual meeting
    • Place of Presentation
      Seattle
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NAD(P)H:quinone oxidoreductase (Nqo1) regulates irritant contact dermatitis2015

    • Author(s)
      Masayuki Kitajima, Akihiro Kimura, Harumi Suzuki
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-01-27  

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