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Synchronized behavior analysis with delayed-mirror system in ASD model primate

Research Project

Project/Area Number 15K21651
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Statistical science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology (2017)
National Center of Neurology and Psychiatry (2015-2016)

Principal Investigator

Mimura Koki  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 研究員(任常) (60747377)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords社会性 / 同調 / 霊長類 / 自閉症 / 空間測定 / 自由行動 / 行動神経学 / 計算モデル
Outline of Final Research Achievements

In this study, we focused on synchronized behavior, one of the significant part of social ability. First, we developed new autism spectrum disorder (ASD) model animal in common marmoset (Callithrix jacchus) with exposed valproate in utero. These animals represented significant atypical brain structure in neonate and confused familial vocalization (Mimura et al., in press). Then, to quantify free moving synchronized behavior, we developed a new motion tracking system by using multi-depth cameras and machine learning algorithm. As a result, we succeeded to track head, body, hip, and face direction of 3D free moving common marmoset without any kind of body markers. These high resolution free movement database could be the basis of mutual interaction analysis with statistical contextual segmentation techniques.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] 3D reconstruction of brain section images for creating axonal projection maps in marmosets.2017

    • Author(s)
      Abe H, Tani T, Mashiko H, Kitamura N, Miyakawa N, Mimura K, Sakai K, Suzuki W, Kurotani T, Mizukami H, Watakabe A, Yamamori T, Ichinohe N.
    • Journal Title

      J Neurosci Methods

      Volume: 286 Pages: 102-113

    • DOI

      10.1016/j.jneumeth.2017.04.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Distrbed Vocal Communication in Common Marmoset Family with an Autism-Model Child2017

    • Author(s)
      Koki Mimura, Keiko Nakagaki, Noritaka Ichinohe
    • Organizer
      24 th Ineternational "Stress and Behavior" Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Atypical Behavioral and Neural Phenotypes in a Common Marmoset Model of Autism Spectrum Disorder2017

    • Author(s)
      Koki Mimura , Chika Sato, Jumpei Matsumoto, Ichio Aoki, Noritaka Ichinohe, Suhara Testuya, Takafumi Minamimoto
    • Organizer
      12th International “Stress and Behavior” Society Regional Conference (Asia)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 3D-Tracker, an open-source 3D video based behavioral analysis system for laboratory animals for neuroscience2017

    • Author(s)
      J. Matsumoto, H. Nishimaru, Y. Takamura, K. Mimura, A. Asaba, W. Suzuki, N. Ichinohe, T. Minamimoto, T. Ono, H. Nishijo
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] げっ歯類とサルのためのオープンソース3次元ビデオ行動解析システムの開発と神経科学への応用2017

    • Author(s)
      松本淳平, 西丸広史, 高村雄策, 三村喬生, 浅場明莉, 鈴木航, 一戸紀孝, 南本敬史, 小野武年, 西条寿夫
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化学遺伝学とPETイメージングの融合による黒質線条体ドーパミン神経活動制御2017

    • Author(s)
      三村 喬生, 永井 裕司, 井上 謙一, 須原 哲也, 高田 昌彦, 南本 敬史
    • Organizer
      第七回 日本マーモセット研究会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機械学習を用いた自由行動下における頭部方向測定法の開発2017

    • Author(s)
      三村 喬生、松本 惇平、西条 寿夫、須原哲也、南本 敬史
    • Organizer
      第七回 日本マーモセット研究会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Atypical behavioral and neural phenotypes in a non-human primate model of autism spectrum disorders2016

    • Author(s)
      K. MIMURA, C. SATO, K. NAKAGAKI, I. AOKI, T. MINAMIMOTO, N. ICHINOHE
    • Organizer
      Sosciety for Neuroscience 46th Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 3D Traker for animal behavior

    • URL

      http://3dtracker.org/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 微細構造研究部(国立精神・神経医療研究センター)

    • URL

      http://www.ncnp.go.jp/nin/guide/r_mic/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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