Differential glycan profiling of MUC1 from pancreatic ductal adenocarcinoma and cholangiocarcinoma
Project/Area Number |
15K21667
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnostics
Bio-related chemistry
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Research Institution | Keio University (2016-2017) National Institute of Advanced Industrial Science and Technology (2015) |
Principal Investigator |
Matsuda Atsushi 慶應義塾大学, 医学部(信濃町), 助教 (30722590)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | MUC1 / 腫瘍マーカー / 糖鎖 / レクチンアレイ / 膵臓癌 / 胆管癌 / ムチン / レクチンマイクロアレイ / 糖鎖プロファイリング / 糖タンパク質 / バイオマーカー / 胆管がん / 膵臓がん |
Outline of Final Research Achievements |
This study demonstrate the development of the mucin glycan profiling targeting to surgical tissue sections from pancreatic ductal adenocarcinoma and cholangiocarcinoma. We establish the glycan profiling of mucin molecules derived from culture cells. Using this method, we next demonstrate the differential mucin glycan profiling targeting to surgical tissue sections from pancreatic ductal adenocarcinoma and cholangiocarcinoma. As the result, we find a specific glycan change according to tumor prognosis after the surgery. Our methodology is expected to applicate to newly biomarker and drug discovery in the future.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma.2017
Author(s)
Tamaki N, Kuno A, Matsuda A, Tsujikawa H, Yamazaki K, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J, Korenaga M, Mizokami M, Kurosaki M, Sakamoto M, Narimatsu H, Izumi N.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 244-244
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Wisteria floribunda Agglutinin-Sialylated Mucin Core Polypeptide 1 is a Sensitive Biomarker for Biliary Tract Carcinoma and Intrahepatic Cholangiocarcinoma: A Multicenter Study.2016
Author(s)
Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
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Journal Title
J Gastroenterol
Volume: 52
Issue: 2
Pages: 218-228
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1.2015
Author(s)
Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H.
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Journal Title
Anal Chem.
Volume: 87(14)
Issue: 14
Pages: 7274-7281
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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