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Diabetic patients clarify the mechanisms of inflammation and organ injury during extracorporeal membrane oxygenation

Research Project

Project/Area Number 15K21692
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Cardiovascular surgery
Research InstitutionNiigata University of Health and Welfare (2016-2017)
National Cardiovascular Center Research Institute (2015)

Principal Investigator

Fujii Yutaka  新潟医療福祉大学, 医療技術学部, 助教 (20589303)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糖尿病 / 補助循環 / 炎症反応 / 酸化ストレス / 体外循環
Outline of Final Research Achievements

In this study, we aimed to elucidate the mechanisms of inflammation and organ injury which diabetic patients undergo during extracorporeal membrane oxygenation.
As a result of the pathological evaluation after the auxiliary circulation, it was found that the injury level tended to be higher in the proximal kidney tubule in the diabetic group.It was also shown that diabetic group was susceptible to inflammation and had high oxidative stress. Our research results can be a material to elucidate the mechanism of inflammation and organ injury suffered by diabetic patients during extracorporeal membrane oxygenation and the relationship between oxidative stress.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Effect of Hydroxyethyl Starch Priming on the Systemic Inflammatory Response and Lung Edema after Cardiopulmonary Bypass in a Rat Model.2017

    • Author(s)
      Fujii Y, Tanabe T, Yamashiro T, Shirai M, Takewa Y, Tatsumi E.
    • Journal Title

      ASAIO J

      Volume: 63(5) Issue: 5 Pages: 618-623

    • DOI

      10.1097/mat.0000000000000543

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiopulmonary bypass with low- versus high-priming volume: comparison of inflammatory responses in a rat model.2016

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, Tatsumi E.
    • Journal Title

      ASAIO J

      Volume: 62 Issue: 3 Pages: 286-290

    • DOI

      10.1097/mat.0000000000000347

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sympathetic hyper-excitation in obesity and pulmonary hypertension - physiological relevance to the 'Obesity Paradox'2016

    • Author(s)
      Crystal Diong, Peter Jones, Hirotsugu Tsuchimochi, Emily Gray, Gillian Hughes, Tadakatsu Inagaki, Carol Bussey, Yutaka Fujii, Keiji Umetani, Mikiyasu Shirai, Daryl Schwenke
    • Journal Title

      International Journal of Obesity

      Volume: 40 Issue: 6 Pages: 938-946

    • DOI

      10.1038/ijo.2016.33

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016

    • Author(s)
      Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 311(2) Issue: 2 Pages: 426-439

    • DOI

      10.1152/ajpregu.00112.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes in inflammatory response during and after cardiopulmonary bypass using a rat extracorporeal circulation model2015

    • Author(s)
      Fujii Y, Shirai M, Pearson JT, Takewa Y, Tatsumi E.
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Volume: Aug Pages: 957-960

    • DOI

      10.1109/embc.2015.7318522

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 補助循環中の炎症反応抑制を目指した白血球除去カラムの開発 ‐ラット補助循環モデルを用いた検討-2015

    • Author(s)
      藤井豊 白井幹康 島垣昌明 富田尚利 上野良之 武輪能明 巽英介
    • Journal Title

      ICUとCCU

      Volume: 39(10) Pages: 627-634

    • NAID

      40020642168

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.2015

    • Author(s)
      Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 14 Issue: 1 Pages: 92-105

    • DOI

      10.1186/s12933-015-0256-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 代用血漿製剤プライミングは補助循環中の炎症反応上昇を抑制する -小動物モデルを用いた検討-2018

    • Author(s)
      藤井 豊,田辺 貴幸,山城 翼,武輪 能明,巽 英介,追手 巍
    • Organizer
      第45回 日本集中治療医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新しい心筋保護法 -SPring 8 で見えてきた可能性-2018

    • Author(s)
      赤松伸朗、藤井 豊、山崎康祥、藤井 豊、三木航太、稲盛修二
    • Organizer
      第48回 日本心臓血管外科学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病における腎虚血 -小動物モデルを用いた病理学的評価-2018

    • Author(s)
      笠原莉奈 池上喜久夫 榎幸太 石山恵利加 糸井拓人 杉森勇斗 轟香奈絵  追手巍 藤井豊
    • Organizer
      第55回 日本糖尿病学会関東甲信越地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] High Oxygen Partial Pressure Generates Reactive Oxygen Species and Pro-inflammatory Cytokines During Cardiopulmonary Bypass2017

    • Author(s)
      Y. Fujii, Y. Takewa, E. Tatsumi, T. Oite
    • Organizer
      ASAIO 63th Annual Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 体外循環中の血糖値と炎症反応の関係性 -小動物体外循環モデルを用いた検討-2017

    • Author(s)
      水野茜、糸井拓人、石山恵利加、榎幸太、笠原莉奈、杉森勇斗、轟香奈絵、藤井豊
    • Organizer
      第 24 回 日本体外循環医学会関東甲信越地方会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 体外循環回路血液接触面積の違いによる全身性炎症反応の検討2016

    • Author(s)
      藤井豊 追手巍 白井幹康 武輪能明  巽英介
    • Organizer
      第42回日本体外循環技術医学会大会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] Cardiopulmonary Bypass With Low-versus High-blood Contact Surface Area: Comparison of Cytokine Level DuringCardiopulmonary Bypass in a Rat Model2016

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, Tatsumi E
    • Organizer
      ASAIO 66th Annual Conference
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 補助循環中、PaO2 300mmHg 以上での管理は全身炎症性反応を助長する。 -小動物モデルを用いた検討-2016

    • Author(s)
      藤井豊 白井幹康 武輪能明 巽英介
    • Organizer
      第26回 日本臨床工学会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Maintenance of normal plasma colloid osmotic pressure suppresses the inflammatory response during cardiopulmonary bypass2016

    • Author(s)
      Fujii Y, Shirai M, Tatsumi E
    • Organizer
      The 93th Annual Meeting of the physiological Society of Japanese
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 血液と体外循環回路の接触面積の違いが生体に与える影響-ラットモデルを用いた評価‐2015

    • Author(s)
      藤井豊 白井幹康 武輪能明 巽英介
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] The Effect of Blood Contact Surface Area and Priming Volume During Cardiopulmonary Bypass -Inflammatory Response Evaluation in a Rat Model-2015

    • Author(s)
      Fujii Y
    • Organizer
      2nd Meeting of The Federation of Asia Perfusion Societies Annual Congress
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 体外循環デバイス開発評価のための小動物モデルの構築2015

    • Author(s)
      藤井豊 白井幹康 築谷 朋典 水野敏秀 武輪能明 巽英介
    • Organizer
      日本機械学会2015年度年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Evaluation of new leukocyte removal column using a rat cardiopulmonary bypass model2015

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, Tatsumi E.
    • Organizer
      42st Annual ESAO Congress
    • Place of Presentation
      Leuven, Belgium
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Changes in Inflammatory Response During and After Cardiopulmonary Bypass Using A Rat Extracorporeal Circulation Model2015

    • Author(s)
      Fujii Y, Shirai M, Pearson JT, Takewa Y, Tatsumi E.
    • Organizer
      37th Annual International IEEE EMBS
    • Place of Presentation
      Milano, Itary
    • Year and Date
      2015-08-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of blood contact surface area reduction during extracorporeal circulation in a rat cardiopulmonary bypass model2015

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, Taenaka Y, Tatsumi E.
    • Organizer
      ASAIO 61th Annual Conference
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 補助循環中の高酸素分圧管理は活性酸素発生を誘発し全身炎症性反応を助長する。 ‐小動物モデルを用いた検討-2015

    • Author(s)
      藤井豊 白井幹康 武輪能明 巽英介
    • Organizer
      第25回 日本臨床工学会
    • Place of Presentation
      福岡
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of the new polymer coating (MDM-coating) for reduce the inflammatory response during ECMO -Evaluation using a small animal ECMO model-2015

    • Author(s)
      Fujii Y, Mizuno T, Takehisa T, Shirai M, Tatsumi E
    • Organizer
      ISHLT 35th Annual Meeting and Scientific Sessions
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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