Diabetic patients clarify the mechanisms of inflammation and organ injury during extracorporeal membrane oxygenation
Project/Area Number |
15K21692
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Emergency medicine
Cardiovascular surgery
|
Research Institution | Niigata University of Health and Welfare (2016-2017) National Cardiovascular Center Research Institute (2015) |
Principal Investigator |
Fujii Yutaka 新潟医療福祉大学, 医療技術学部, 助教 (20589303)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 糖尿病 / 補助循環 / 炎症反応 / 酸化ストレス / 体外循環 |
Outline of Final Research Achievements |
In this study, we aimed to elucidate the mechanisms of inflammation and organ injury which diabetic patients undergo during extracorporeal membrane oxygenation. As a result of the pathological evaluation after the auxiliary circulation, it was found that the injury level tended to be higher in the proximal kidney tubule in the diabetic group.It was also shown that diabetic group was susceptible to inflammation and had high oxidative stress. Our research results can be a material to elucidate the mechanism of inflammation and organ injury suffered by diabetic patients during extracorporeal membrane oxygenation and the relationship between oxidative stress.
|
Report
(4 results)
Research Products
(24 results)
-
-
-
[Journal Article] Sympathetic hyper-excitation in obesity and pulmonary hypertension - physiological relevance to the 'Obesity Paradox'2016
Author(s)
Crystal Diong, Peter Jones, Hirotsugu Tsuchimochi, Emily Gray, Gillian Hughes, Tadakatsu Inagaki, Carol Bussey, Yutaka Fujii, Keiji Umetani, Mikiyasu Shirai, Daryl Schwenke
-
Journal Title
International Journal of Obesity
Volume: 40
Issue: 6
Pages: 938-946
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
[Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016
Author(s)
Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
-
Journal Title
Am J Physiol Regul Integr Comp Physiol.
Volume: 311(2)
Issue: 2
Pages: 426-439
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
[Journal Article] Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.2015
Author(s)
Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.
-
Journal Title
Cardiovasc Diabetol
Volume: 14
Issue: 1
Pages: 92-105
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-