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Development of core-shell cell structure called CELL CAPSULE for myocardial tissue regeneration by using cell self-organization inducible surfaces

Research Project

Project/Area Number 15K21693
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Biomedical engineering/Biomaterial science and engineering
Research InstitutionOkayama University of Science (2016)
National Cardiovascular Center Research Institute (2015)

Principal Investigator

IWAI Ryosuke  岡山理科大学, 付置研究所, 講師 (60611481)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自己組織化 / スフェロイド / 再生医療 / 細胞工学 / DDS / 心筋細胞 / 間葉系幹細胞 / 組織工学 / 3次元培養 / 心筋組織体
Outline of Final Research Achievements

We have successfully prepared a novel cell aggregated construct having core-shell structure as we called “CELL CAPSULE” that contains therapeutic cells as core cells and support cells as shell cells by using our developed cell self-organization inducible culture surfaces. The core cells of CELL CAPSULE could reconstruct tissues within 3 weeks after their transplantation for outer surface of rat aorta. It is expected that aggressive regeneration of myocardial tissues could be achieved by the transplantation of CELL CAPSULE composed of cardiomyocytes as core cells and mesenchymal stem cells having anti-inflammatory and homing potential as shell cells.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (13 results) (of which Overseas: 1 results)

  • [Journal Article] Induction of cell self-organization on weakly positively charged surfaces prepared by the deposition of polyion complex nanoparticles of thermoresponsive, zwitterionic copolymers.2016

    • Author(s)
      Iwai R, Haruki R, Nemoto Y, Nakayama Y
    • Journal Title

      J Biomedical Materials Research B: Applied Biomaterials

      Volume: In press Issue: 5 Pages: 1009-1015

    • DOI

      10.1002/jbm.b.33638

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 岩井良輔、長島諒、根本泰、中山泰秀2017

    • Author(s)
      2次元接着細胞の自己凝集化技術を用いた3次元細胞回路の作製
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター、宮城県仙台市
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 岩井良輔、根本泰、中山泰秀2016

    • Author(s)
      細胞の自己集合化表面(CAT)を基盤とする 3次元組織構築の要素技術開発 形状とサイズ制御、大量生産化
    • Organizer
      第54回日本人工臓器学会大会
    • Place of Presentation
      米子コンベンションセンター、鳥取県米子市
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞の自己集合化誘導コーティング剤(CAT)を用いたスキャホールドフリー軟骨リングの簡易作製2016

    • Author(s)
      岩井良輔、根本泰、中山泰秀
    • Organizer
      第68回日本生物工学会大会
    • Place of Presentation
      富山国際会議場、富山県富山市
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 接着細胞の自己凝集化を誘導する培養表面の開発: 播種した翌日に任意の形とサイズの細胞凝集体が出来上がる2016

    • Author(s)
      岩井良輔
    • Organizer
      第4回細胞凝集研究会
    • Place of Presentation
      全日空ホテル、北海道札幌市
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] CATを用いる組織形成技術の展開: スキャホールドフリー軟骨輪様組織体の作製 ~気管様組織体の開発2016

    • Author(s)
      岩井良輔、八木翔輝、根本泰、中山泰秀
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
  • [Presentation] One-Day-Aggregated Spheroids(ODAS)技術の展開 再生医療および創薬用途を指向した細胞スフェロイドの作製2016

    • Author(s)
      岩井良輔、根本泰、中山泰秀
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
  • [Book] バイオ・医療への3Dプリンティング技術の開発最前線2016

    • Author(s)
      岩井良輔、中山泰秀
    • Total Pages
      230
    • Publisher
      シーエムシー・リサーチ
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 立体構造体の作製装置,及び立体構造体の作製方法2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-124458
    • Filing Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞培養器2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞培養器及び細胞培養器の製造方法2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-001765
    • Filing Date
      2016-01-07
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞構造体の製造方法2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-016436
    • Filing Date
      2016-01-29
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞構造体の製造方法、細胞構造体、細胞培養器2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-02-15
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞構造体の製造方法2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-053081
    • Filing Date
      2016-03-16
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞構造体の製造方法2016

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-053082
    • Filing Date
      2016-03-16
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞培養器2015

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-129266
    • Filing Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞構造体の製造方法、細胞構造体2015

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-129251
    • Filing Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞培養容器の製造方法2015

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-129249
    • Filing Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] カプセル化細胞構造体の製造方法、及びカプセル化細胞構造体2015

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-185841
    • Filing Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞培養器及び細胞培養器の製造方法2015

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-209142
    • Filing Date
      2015-10-23
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞構造体の製造方法2015

    • Inventor(s)
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Holder
      根本泰、岩井良輔、中山泰秀
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-234947
    • Filing Date
      2015-12-01
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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