Creation of Synthetic Bacteriophages -Treatment of Drug-Resistant Bacterial Infections and Human Microbiota Editing-
| Project/Area Number |
15K21770
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| Research Category |
Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | Gifu University |
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Principal Investigator |
ANDO Hiroki 岐阜大学, 大学院医学系研究科, 特任准教授 (70462786)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
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| Keywords | バクテリオファージ / 合成生物学 / ファージ療法 / ファージセラピー / ファージ / 人工バクテリオファージ / 薬剤耐性菌 / 細菌叢 / 薬剤耐性細菌 |
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| Outline of Final Research Achievements |
The "Synthetic Engineering Platform" was developed. The platform can construct bacteriophage genomes from DNA fragments and reboot functional phages. A variety of synthetic phages was created. In addition, biological containment methods were developed to enable the use of synthetic phages in, for example, phage therapy and microbiota editing. Biocontained phages showed therapeutic effects comparable to those of wild-type phages in phage therapy experiments. I have filed a patent application and published a paper on the results of this research.
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| Academic Significance and Societal Importance of the Research Achievements |
様々なファージを改変して起動できるプラットフォームは、ファージの基礎研究・応用研究を推進する。また、ファージの生物学的封じ込めは、例えば、改変型ファージの研究室外での利用を考えた際に有力な拡散防止策になりえる。本プラットフォームと生物学的封じ込め法はファージ生物学と関連分野における新しい基盤技術になるものと考えている。
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Report
(7 results)
Research Products
(31 results)
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[Journal Article] Recovery of mycobacteriophages from archival stocks stored for approximately 50 years in Japan.2018
Author(s)
Ujihara T, Uchiyama J, Nasukawa T, Ando H, Murakami H, Ohara N, Ogawa M, Yamazaki T, Daibata M, Sakaguchi M, Matsuzaki S.
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Journal Title
Archives of Virology
Volume: in press
Issue: 7
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] アトピー性皮膚炎由来黄色ブドウ球菌に対する表皮ブドウ球菌併用ファージセラピーの検証2020
Author(s)
島守祐月, 鈴木徹, 満仲翔一, 相沢慎一, 山下弘高, Ajeng Pramono, 久堀智子, 永井宏樹, 北尾公英, 武田茂樹, 安藤弘樹
Organizer
第65回日本ブドウ球菌研究会
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