Construction of heart failure personalized medicine strategy by heart molecular imaging international collaborative research
Project/Area Number |
15K21774
|
Research Category |
Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Okayama University (2018-2019) National Cardiovascular Center Research Institute (2015-2017) |
Principal Investigator |
HIGUCHI Takahiro 岡山大学, 大学院医歯薬学総合研究科, 教授 (30739850)
|
Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Kazuhito 国立循環器病研究センター, 画像診断医学部, 客員研究員 (90393347)
KIMURA Hiroyuki 京都薬科大学, 代謝分析学分野, 准教授 (50437240)
HASEGAWA Koki 京都薬科大学, 共同利用機器センター, 准教授 (50525798)
FUKUCHI Kazuki 大阪大学, 大学院医学系研究科保健学専攻・医療技術科学分野医用物理工学講座, 教授 (50720687)
SAITO Shigeyoshi 大阪大学, 大学院医学系研究科保健学専攻・放射線技術科学専攻医用物理学講座, 助教 (40583068)
FUKUSHIMA Kenji 埼玉医科大学, 医学部, 非常勤講師 (50408613)
ZENIYA Tsutomu 弘前大学, 大学院理工学研究科, 教授 (50443487)
NAKAJIMA Kenichi 金沢大学, 医薬保健研究域医学系核医学, 准教授・病院臨床教授 (00167545)
TAKI Junichi 金沢大学, 附属病院, 講師 (10251927)
YAMAYA Taiga 国立研究開発法人量子科学技術研究開発機構放射線医学総合研究所, 計測・線量評価部, チームリーダー (40392245)
TORIUMI Fujio 東京大学, 大学院工学系研究科システム創生学専攻, 准教授 (30377775)
SHIOYA Kyoko 国立循環器病研究センター, 研究推進支援部, 特任室長 (50426516)
|
Project Period (FY) |
2016 – 2019
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
|
Keywords | 心不全 / 分子イメージング / 核医学 / PET / 画像診断 / 交感神経 / アンジオテンシン / 細胞治療 / アンギオテンシン / 医療・福祉 / 放射線 / 循環器・高血圧 |
Outline of Final Research Achievements |
This research project aims to develop a new PET molecular imaging technology and establish a new treatment strategy for patients with heart failure. The principle investigator (PI) has set up a new research base in Japan as the director of the bio-medical imaging department of the National Cardiovascular Research Center. While transferring various knowledge and technologies to Japanese researchers, we have created an environment that enables to conduct state of the art PET imaging research. Since last year, PI has been a professor at Okayama University and has been accelerating the exchange of technology and young researchers with various countries. Furthermore, among the new tracer technology developed in this research project, we have identified multiple tracer candidates that are considered to be highly effective in diagnosing heart failure and will continue further study for clinical application.
|
Academic Significance and Societal Importance of the Research Achievements |
心不全の個別化医療戦略の基盤となる心臓PET分子イメージング技術の開発を通して、国内に最先端の国際共同研究拠点を立ち上げた。今後も、この研究環境をベースに、腫瘍、脳、老化などの様々な疾患や病態をターゲットにした分子イメージング開発へ発展可能である。
|
Report
(5 results)
Research Products
(104 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] 68Ga-PSMA I&T PET/CT for primary staging of prostate cancer.2020
Author(s)
Wojciech Cytawa, Anna Katharina Seitz, Stefan Kircher, Kazuhito Fukushima, Johannes Tran-Gia, Andreas Schirbel, Tomasz Bandurski, Piotr Lass, Markus Krebs, Wojciech Polom, Marcin Matuszewski, Hans-Jürgen Wester, Andreas K Buck, Hubert Kübler, Constantin Lapa
-
Journal Title
Eur J Nucl Med Mol Imaging.
Volume: 47
Issue: 1
Pages: 168-177
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.2019
Author(s)
Hara A, Kobayashi H, Asai N, Saito S, Higuchi T, Kato K, Okumura T, Bando YK, Takefuji M, Mizutani Y, Miyai Y, Saito S, Maruyama S, Maeda K, Ouchi N, Nagasaka A, Miyata T, Mii S, Kioka N, Worthley DL, Murohara T, Takahashi M, Enomoto A.
-
Journal Title
Circ. Res.
Volume: 125
Issue: 4
Pages: 414-430
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
[Journal Article] Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET.2018
Author(s)
Werner RA, Eissler C, Hayakawa N, Arias-Loza P, Wakabayashi H, Javadi MS, Chen X, Shinaji T, Lapa C, Pelzer T, Higuchi T.
-
Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 17631-17631
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects.2018
Author(s)
Werner RA, Ordonez AA, Sanchez-Bautista J, Marcus C, Lapa C, Rowe SP, Pomper MG, Leal JP, Lodge MA, Javadi MS, Jain SK, Higuchi T.
-
Journal Title
Clin Nucl Med.
Volume: 44
Issue: 5
Pages: 410-411
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Journal Article] Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted (18)F-DCFPyL in peripheral ganglia2017
Author(s)
Werner RA, Sheikhbahaei S, Jones KM, Javadi MS, Solnes LB, Ross AE, Allaf ME, Pienta KJ, Lapa C, Buck AK, Higuchi T, Pomper MG, Gorin MA, Rowe SP
-
Journal Title
Ann Nucl Med 2017
Volume: 31
Issue: 9
Pages: 696-702
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Stroke-induced chronic systolic dysfunction driven by sympathetic overactivity2017
Author(s)
Bieber, Werner RA, Tanai E, Hofmann U, Higuchi T, Schuh K, Heuschmann PU, Frantz S, Ritter O, Kraft P, Kleinschnitz C.
-
Journal Title
Ann Neurol
Volume: 82
Issue: 5
Pages: 729-743
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Predictive value of FDG-PET in patients with advanced medullary thyroid carcinoma treated with vandetanib.2017
Author(s)
Werner RA, Schmid JS, Higuchi T, Javadi MS, Rowe SP, Markl B, Aulmann C, Fassnacht M, Kroiss M, Reiners C, Buck AK, Kreissl M, Lapa C.
-
Journal Title
Journal of Nuclear Medicine
Volume: 117
Issue: 5
Pages: 199778-199778
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Defining the Added Value of 99mTc-MIBI SPECT/CT to Conventional Cross-Sectional Imaging in the Characterization of Enhancing Solid Renal Masses.2017
Author(s)
Sheikhbahaei S, Jones CS, Porter KK, Rowe SP, Gorin MA, Baras AS, Pierorazio PM, Ball MW, Higuchi T, Johnson PT, Solnes LB, Epstein JI, Allaf ME, Javadi MS.
-
Journal Title
Clin Nucl Med.
Volume: 42
Issue: 4
Pages: 188-193
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
[Journal Article] Survival prediction in patients undergoing radionuclide therapy based on intratumoral somatostatin-receptor heterogeneity.2017
Author(s)
Werner RA, Lapa C, Ilhan H, Higuchi T, Buck AK, Lehner S, Bartenstein P, Bengel F, Schatka I, Muegge DO, Papp L, Zsótér N, Große-Ophoff T, Essler M, Bundschuh RA
-
Journal Title
Oncotarget
Volume: 8
Issue: 4
Pages: 7039-7049
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
[Journal Article] Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors-a Triple Tracer Comparative Approach2017
Author(s)
Rudolf A. Werner, Alexander Weich, Takahiro Higuchi, Jan S. Schmid, Andreas Schirbel, Michael Lassmann, Vanessa Wild, Martina Rudelius, Theodor Kudlich, Ken Herrmann, Michael scheurlen, Andreas K. Buck, Saskia Kropf, Hans-Jürgen Wester, Constantin Lapa
-
Journal Title
Theranostics
Volume: 7
Issue: 6
Pages: 1489-1498
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-