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Developtment of novel rehabilitation approach based on cortical plasticity induced by visual stimulus(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0117
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNagoya University

Principal Investigator

NOJIMA IPPEI  名古屋大学, 医学系研究科(保健), 助教 (20646286)

Research Collaborator Cohen Leonard G  National Institute of Health, Human Cortical Physiology and Neuroehabilitation, Senior Investigator
Project Period (FY) 2016 – 2018
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Keywords運動学習 / 脳内ネットワーク / MEG / EEG / リハビリテーション / 可塑性 / 神経科学
Outline of Final Research Achievements

In order to investigate the cortical network associated with motor learning, we measured brain activity at resting-state using magnetoencephalography (MEG) and examined the relationship with the change of motor performance. As a result, it revealed that the behavioral improvement in motor skills after one week was significantly better connectivity between the primary motor area and the pre-motor area on the opposite side of the target hand measured before training. Especially, a relatively high frequency hand (the gamma band) of cortical oscillation was associated to the behavioral improvement. This finding was considered to be a finding contributing to the development of novel rehabilitation approach for neurological disorder patients.

Academic Significance and Societal Importance of the Research Achievements

運動技能を測定する際に問題となるのは、運動速度と正確性がトレードオフの関係にあり、一方を重視することで他方が低下するという点であり、運動技能を測定する際に常に問題となっていた。本研究では研究室で開発されたSVIPTという運動速度と正確性から技能を算出できる課題を使い、真の運動技能と脳活動との関係を検討している。また、脳波では測定が難しいγ帯域という高周波数帯域と運動技能との関係を明らかにしており、運動を学習する際の脳活動における生理学的根拠となりうる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] アメリカ国立衛生研究所(米国)2017

    • Year and Date
      2017-04-01
    • Related Report
      2018 Annual Research Report
  • [Journal Article] Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning2019

    • Author(s)
      Nojima I, Watanabe T, Goyda T, Sugata H, Ikeda T, Mima T.
    • Journal Title

      Neurosci Lett

      Volume: 696 Pages: 33-37

    • DOI

      10.1016/j.neulet.2018.12.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voluntary control of forward leaning posture relates to low-frequency neural inputs to the medial gastrocnemius muscle2018

    • Author(s)
      Watanabe T, Nojima I, Sugiura H, Yacoubi B, Christou EA
    • Journal Title

      Gait & Posture

      Volume: 68 Pages: 187-192

    • DOI

      10.1016/j.gaitpost.2018.11.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatigue-induced decline in low-frequency common input to bilateral and unilateral plantar flexors during quiet standing2018

    • Author(s)
      Watanabe Tatsunori、Saito Kotaro、Ishida Kazuto、Tanabe Shigeo、Nojima Ippei
    • Journal Title

      Neuroscience Letters

      Volume: 686 Pages: 193-197

    • DOI

      10.1016/j.neulet.2018.09.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-Related Declines in the Ability to Modulate Common Input to Bilateral and Unilateral Plantar Flexors During Forward Postural Lean2018

    • Author(s)
      Watanabe T, Saito K, Ishida K, Tanabe S, Nojima I
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fnhum.2018.00254

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of auditory stimulus on executive function and execution time during cognitively demanding stepping task in patients with Parkinson's disease.2018

    • Author(s)
      Watanabe T, Saito K, Ishida K, Tanabe S, Horiba M, Itamoto S, Ueki Y, Wada I, Nojima I.
    • Journal Title

      Neurosci Lett

      Volume: 674 Pages: 101-105

    • DOI

      10.1016/j.neulet.2018.03.032

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of EMG-EMG Coherence in a Choice Stepping Task2018

    • Author(s)
      Nojima Ippei、Watanabe Tatsunori、Saito Kotaro、Tanabe Shigeo、Kanazawa Hoshinori
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 111-111

    • DOI

      10.3389/fnhum.2018.00050

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Transcranial static magnetic stimulation over human primary motor cortex can modulate implicit motor learning2018

    • Author(s)
      Nojima I, Watanabe T, Hirayama M, Sugata H, Ikeda T, Mima T
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconsolidation task performed with untrained limb enhances motor skill acquisition2018

    • Author(s)
      Gyoda T, Ishida K, Watanabe T, Nojima I
    • Organizer
      Society for Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動技能再取得に対する両側性転位効果の検討2018

    • Author(s)
      行田智哉、石田和人、渡邊龍憲、野嶌一平
    • Organizer
      Motor control研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 認知機能低下高齢者における歩行パラメータ変化2018

    • Author(s)
      野嶌一平、野口泰司、松下光次朗、齊藤浩太郎、菅田陽怜、杉浦英志
    • Organizer
      日本予防理学療法学会学術大会
    • Related Report
      2018 Annual Research Report

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Published: 2016-10-04   Modified: 2020-03-30  

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