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Creation of zipper-like molecules for inducing intercellular adhesion and analysis of intercellular interaction(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0230
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokyo

Principal Investigator

Teramura Yuji  東京大学, 大学院工学系研究科(工学部), 准教授 (10365421)

Project Period (FY) 2016 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywords細胞表面修飾 / 細胞移植 / 臓器移植 / PEG脂質 / 腎移植 / 虚血再灌流障害 / 凝固系 / 補体系 / 腎臓移植 / 膵島移植 / 表面修飾 / 虚血再韓流障害 / 生体材料
Outline of Final Research Achievements

In this Fostering Joint International Research, we aimed to establish cell-micro encapsulation methods to prevent immune rejection reactions based on technique using poly(ethylene glycol)-conjugated phospholipid (PEG-lipid). We successfully collaborated with Prof Bo Nilsson in Uppsala University (in Sweden), who has been working with clinical cell transplantation. In this study, we focused on the cellular surface modification to inhibit immune responses which occurred immediately after transplantation, and succeeded in the regulation with PEG-lipids.

Academic Significance and Societal Importance of the Research Achievements

糖尿病治療を目的とした膵ランゲルハンス島(膵島)移植、様々な疾患の治療に検討されている間葉系幹細胞(MSC)および腎疾患に対する腎臓移植では、移植直後の炎症反応が原因で、細胞傷害を受けるため、生着率が大きく低下する。そのため、本研究成果は、細胞移植や臓器移植の生着率の向上に大きく寄与するものである。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2020 2019 2018 2017 2016

All Int'l Joint Research (1 results) Journal Article (17 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 16 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 6 results)

  • [Int'l Joint Research] ウプサラ大学ルドベック研究所(スウェーデン)2017

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Quantitative evaluation of the impact of artificial cell adhesion via DNA hybridization on E-cadherin-mediated cell adhesion2020

    • Author(s)
      Togo Shodai、Sato Ken、Kawamura Ryuzo、Kobayashi Naritaka、Noiri Makoto、Nakabayashi Seiichiro、Teramura Yuji、Yoshikawa Hiroshi Y.
    • Journal Title

      APL Bioengineering

      Volume: 4 Issue: 1 Pages: 016103-016103

    • DOI

      10.1063/1.5123749

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poly(2-aminoethyl methacrylate)-based polyampholyte brush surface with carboxylic groups to improve blood compatibility2020

    • Author(s)
      Tomoyuki Azuma, Taishi Matsushita, Vivek Anand Manivel, Kristina N Ekdahl, Bo Nilsson, Yuji Teramura and Madoka Takai
    • Journal Title

      J Biomater Sci Polym Ed

      Volume: 31 Issue: 5 Pages: 679-693

    • DOI

      10.1080/09205063.2019.1710900

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combination of two antithrombogenic methodologies for preventing thrombus formation on a poly(ether ether ketone) substrate2020

    • Author(s)
      Kazuhiko Ishihara, Satoru Yanokuchi, Yuji Teramura, Kyoko Fukazawa
    • Journal Title

      Colloid Surface B

      Volume: - Pages: 111021-111021

    • DOI

      10.1016/j.colsurfb.2020.111021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞表面の工学的改質がもたらすバイオメディカル分野における可能性2020

    • Author(s)
      寺村裕治、石原一彦
    • Journal Title

      バイオマテリアル

      Volume: 38 Pages: 132-134

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimization of Islet Microencapsulation with Thin Polymer Membranes for Long-Term Stability2019

    • Author(s)
      Shota Toda, Kenta Asawa, Artin Fattah, Naoko Nakamura, Kristina N Ekdah, Bo Nilsson, Yuji Teramura
    • Journal Title

      Micromachines

      Volume: 10 Issue: 11 Pages: 755-755

    • DOI

      10.3390/mi10110755

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modification of human MSC surface with oligopeptide-PEG-lipids for selective binding to activated endothelium2019

    • Author(s)
      Makoto Noiri, Kenta Asawa, Naoya Okada1, Tomonobu Kodama, Yuichi Murayama, Yuuki Inoue, Kazuhiko Ishihara, Kristina N Ekdahl, Bo Nilsson, and Yuji Teramura
    • Journal Title

      J Biomed Mater Res Part A

      Volume: - Issue: 8 Pages: 1779-1792

    • DOI

      10.1002/jbm.a.36697

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Validation of an MPC polymer coating to reduce surface-induced cascade system activation in whole blood in in vitro and in vivo models2019

    • Author(s)
      Sana Asif, Kenta Asawa, Yuuki Inoue, Kazuhiko Ishihara, Bjorn Lindell, Robin Holmgren, Bo Nilsson, Anneli Ryden, Marianne Jensen-Waern, Yuji Teramura, Kristina N Ekdahl
    • Journal Title

      Macromolecular Bioscience

      Volume: - Issue: 5 Pages: 1800485-1800485

    • DOI

      10.1002/mabi.201800485

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of cell adhesive molecules attached onto PEG-lipid-modified fluid surfaces on cell adhesion2018

    • Author(s)
      Makoto Noiri, Keiichiro Kushiro, Shodai Togo, Ken Sato, Hiroshi Y. Yoshikawa, Madoka Takai and Yuji Teramura
    • Journal Title

      Colloid Surface B

      Volume: 175 Pages: 375-383

    • DOI

      10.1016/j.colsurfb.2018.12.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid and highly efficient capture and release of cancer cells using polymeric microfibers immobilized with enzyme-cleavable peptides2018

    • Author(s)
      Akifumi Yoshihara, Ryota Sekine, Takayuki Ueki, Yasuhito Kondo, Yoshiyuki, Sunaga, Tadashi Nakaji-Hirabayashi, Yuji Teramura and Madoka Takai
    • Journal Title

      Acta Biomaterialia

      Volume: 67 Pages: 32-41

    • DOI

      10.1016/j.actbio.2017.11.055

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Application of Cell Glue2018

    • Author(s)
      寺村裕治
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 75 Issue: 2 Pages: 103-115

    • DOI

      10.1295/koron.2017-0052

    • NAID

      130006528537

    • ISSN
      0386-2186, 1881-5685
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quartz Crystal Microbalance2018

    • Author(s)
      Yuji Teramura and Madoka Takai
    • Journal Title

      Compendium of Surface and Interface Analysis

      Volume: なし Pages: 509-520

    • DOI

      10.1007/978-981-10-6156-1_83

    • ISBN
      9789811061554, 9789811061561
    • Related Report
      2017 Research-status Report
  • [Journal Article] Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate2017

    • Author(s)
      Ryuichi Ohgaki, Yuji Teramura, Daichi Hayashi, Suguru Okuda, Shushi Nagamori, Madoka Taka and Yoshikatsu Kanai
    • Journal Title

      Sci Res

      Volume: 7 Issue: 1 Pages: 17484-17484

    • DOI

      10.1038/s41598-017-17459-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell Adhesion Induced Using Surface Modification with Cell-Penetrating Peptide-Conjugated Poly(ethylene glycol)-Lipid: A New Cell Glue for 3D Cell-Based Structures2017

    • Author(s)
      Yuji Teramura, Sana Asif, Kristina Nilsson-Ekdahl, Elisabet Gustafson, Bo Nilsson,
    • Journal Title

      ACS Appl Mater Interfaces

      Volume: 11 Issue: 1 Pages: 244-254

    • DOI

      10.1021/acsami.6b14584

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Heparinization of cell surfaces with short peptide-conjugated PEG-lipids regulates thromboinflammation in transplantation of human MSCs and hepatocytes2016

    • Author(s)
      Sana Asif, Kristina Nilsson-Ekdahl, Karin Fromell, Elisabet Gustafson, Andreea Barbu, Katarina Le Blanc, Bo Nilsson, and Yuji Teramura
    • Journal Title

      Acta Biomaterialia

      Volume: 35 Pages: 194-205

    • DOI

      10.1016/j.actbio.2016.02.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dangerous liaisons: Complement, coagulation, and kallikrein/kinin crosstalk act as a linchpin in the events leading to thromboinflammation2016

    • Author(s)
      Kristina Nilsson-Ekdahl, Yuji Teramura, Osama A. Hamad, Sana Asif, Claudia Durhkop, Karin Fromell, Elisabet Gustafson, Jaan Hong, Huda Kozarcanin, Peetra Magnusson, Marcus Huber-Lang, Peter Garred, Bo Nilsson
    • Journal Title

      Immunological Reviews

      Volume: 274 Issue: 1 Pages: 245-269

    • DOI

      10.1111/imr.12471

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Complement inhibition in biomaterial- and biosurface-induced thromboinflammation2016

    • Author(s)
      Kristina N Ekdahl, Shan Huang, Bo Nilsson, Yuji Teramura
    • Journal Title

      Seminars in Immunology

      Volume: 28 Issue: 3 Pages: 268-277

    • DOI

      10.1016/j.smim.2016.04.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A hybrid of cells and pancreatic islets toward a new bioartificial pancreas2016

    • Author(s)
      Yuji Teramura, Kristina Nilsson-Ekdahl, and Andreea Barbu
    • Journal Title

      Regenerative Therapy

      Volume: 4 Pages: 62-68

    • DOI

      10.1016/j.reth.2016.03.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] MPCポリマーコーティングによる凝固系・補体系の活性化抑制2019

    • Author(s)
      浅輪健大, ASIF Sana, 井上祐貴, 石原一彦, NILSSON Bo, 寺村裕治
    • Organizer
      第41回日本バイオマテリアル学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 臨床で役に立つ医工学研究を目指して -細胞移植と臓器移植を中心に-2019

    • Author(s)
      寺村裕治
    • Organizer
      第69回医用高分子研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Cell surface engineering using amphiphilic polymers for cell manipulation2019

    • Author(s)
      Yuji Teramura
    • Organizer
      Symposium for Crossing Borders in Medical Nanoscience and Biomaterials, Karolinska Institute, Stockholm
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 留置したステントやコイルの血管内皮化度を調べるイメージング材料を目指して2019

    • Author(s)
      寺村裕治
    • Organizer
      東京大学医学部附属病院 先端医療シーズ開発フォーラム2019 「アカデミアによるイノベーションの加速」
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Cell surface engineering for biomedical applications2019

    • Author(s)
      Yuji Teramura
    • Organizer
      The University of Tokyo-iCONM-NANOTEC Joint Research Meeting on Precision Nanomedicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell surface engineering for biomedical application2018

    • Author(s)
      Yuji Teramura
    • Organizer
      Seminar series in Crossing-Borders, Karolinska Institute, Stockholm
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] PEG 脂質による血管内皮のコーティングとブタ腎移植 における虚血再灌流障害への保護効果2018

    • Author(s)
      寺村裕治, Alireza Biglarnia, Marianne Jensen-Waern, Sana Asif・Kristina Nilsson-Ekdahl・Bo Nilsson
    • Organizer
      第47回医用高分子シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] Protective role of PEG-phospholipid conjugate in reducing ischemic reperfusion injury in kidney transplantation2018

    • Author(s)
      Yuji Teramura, Sana Asif, Kristina N. Ekdahl, Elin Manell, Alireza Biglarnia, Marianne Jensen-Waern, Bo Nilsson
    • Organizer
      Biointerfaces International 2018 Zurich
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A new cell glue for 3D cell structures: Induced cell adhesion using surface modification with cellpenetrating peptide-PEG-lipid2018

    • Author(s)
      Yuji Teramura, Sana Asif, Kristina N. Ekdahl, Elisabet Gustafson, Bo Nilsson
    • Organizer
      5th TERMIS World Congress-2018 Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heparinization of cell surface with short peptide-conjugated PEG-lipids for regulation of thromboinflamation2016

    • Author(s)
      Yuji Teramura, Sana Asif, Kristina Ekdahl, Elisabet Gustafson, Katarina Le Blanc, Bo Nilsson
    • Organizer
      2nd International Conference on Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell surface engineering with heparin conjugates using a short peptide-conjugated PEG-lipid for regulation of thromboinflammation in transplantation of human MSC and hepatocyte2016

    • Author(s)
      Yuji Teramura, Sana Asif, Kristina N. Ekdahl, Elisabet Gustafson, Katarina Le Blanc, Bo Nilsson
    • Organizer
      European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2016
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2016-06-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-10-04   Modified: 2023-03-16  

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