The role of canine AIM in histiocytic sarcoma(Fostering Joint International Research)

• Project/Area Number: 15KK0275
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Yonezawa Tomohiro 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10433715)
• Research Collaborator: Ruffell Brian Moffitt cancer research center
• Project Period (FY): 2016 – 2017
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: マクロファージ / 組織球性肉腫 / 犬 / アポトーシス / 抗体 / がん免疫 / 獣医学 / 内科

Outline of Final Research Achievements

Tumor-associated macrophage (TAM) is reported to be closely related to malignancy of tumorgenesis. However, it is unknown how macrophage can transverse into TAM. We have focused on a specific protein, apoptosis inhibitor of macrophage (AIM), which is expressed in macrophages. In this study, it is found that AIM is highly expressed in TAM and AIM inhibited apoptosis of these cells in vitro. It is also found that AIM could bind some factor of apoptosis pathway, suggesting that AIM should inhibit apoptosis via binding it.

Research Products

• [Int'l Joint Research] Moffitt Cancer Center(米国) (2016)
  • Year and Date: 2016-10-01
• [Journal Article] Endoscopic Cytology for the Diagnosis of Chronic Enteritis and Intestinal Lymphoma in Dogs (2017)
  • Author(s): Maeda S.、Tsuboi M.、Sakai K.、Ohno K.、Fukushima K.、Kanemoto H.、Hiyoshi-Kanemoto S.、Goto-Koshino Y.、Chambers J. K.、Yonezawa T.、Uchida K.、Matsuki N.
  • Journal Title: Veterinary Pathology Volume: 54 Issue: 4 Pages: 595-604
  • DOI: 10.1177/0300985817705175
  • Peer Reviewed
• [Journal Article] Density of tumor-infiltrating granzyme B-positive cells predicts favorable prognosis in dogs with transitional cell carcinoma (2017)
  • Author(s): Inoue Akiko、Maeda Shingo、Kinoshita Ryohei、Tsuboi Masaya、Yonezawa Tomohiro、Matsuki Naoaki
  • Journal Title: Veterinary Immunology and Immunopathology Volume: 190 Pages: 53-56
  • DOI: 10.1016/j.vetimm.2017.07.001
  • Peer Reviewed
• [Journal Article] Decreased plasma amino acid concentrations in cats with chronic gastrointestinal diseases and their possible contribution in the inflammatory response. (2017)
  • Author(s): Sakai K, Maeda S, Yonezawa T, Matsuki N.
  • Journal Title: Vet Immunol Immunopathol. Volume: 195: Pages: 1-6
  • Peer Reviewed
• [Journal Article] Fecal microbiome in dogs with inflammatory bowel disease and intestinal lymphoma. (2017)
  • Author(s): Omori M, Maeda S, Igarashi H, Ohno K, Sakai K, Yonezawa T, Horigome A, Odamaki T, Matsuki N.
  • Journal Title: J Vet Med Sci. Volume: 79(11) Pages: 1840-1847
  • NAID: 130006206562
  • Peer Reviewed
• [Journal Article] Presence of contagious yawning in sheep (2017)
  • Author(s): Yonezawa Tomohiro、Sato Kohei、Uchida Mona、Matsuki Naoaki、Yamazaki Atusi
  • Journal Title: Animal Science Journal Volume: 88 Issue: 1 Pages: 195-200
  • DOI: 10.1111/asj.12681
  • Peer Reviewed / Open Access
• [Journal Article] Cycle Influences Spontaneous Delivery in Cows. (2016)
  • Author(s): Yonezawa T, Uchida M, Tomioka M, Matsuki N
  • Journal Title: PLoS One Volume: 11(8) Issue: 8 Pages: e0161735-e0161735
  • DOI: 10.1371/journal.pone.0161735
  • Peer Reviewed / Open Access
• [Journal Article] Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines (2016)
  • Author(s): Uchida M, Saeki K, Maeda S, Tamahara S, Yonezawa T, Matsuki N
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 9 Pages: 1515-1520
  • DOI: 10.1292/jvms.16-0120
  • NAID: 130005598036
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prolactin suppression of Gonadotropin releasing hormone initiation of mammary gland involution in female rats. (2016)
  • Author(s): Rieanrakwong D, Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Hasegawa Y, Kawaminami M.
  • Journal Title: Endocrinol Volume: 157(7) Issue: 7 Pages: 2750-2758
  • DOI: 10.1210/en.2016-1180
  • Peer Reviewed / Open Access
• [Journal Article] Synovial fluid matrix metalloproteinase-2 and -9 activities in dogs suffering from joint disorders (2016)
  • Author(s): Murakami K, Maeda S, Yonezawa T, Matsuki N
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 6 Pages: 1051-1054
  • DOI: 10.1292/jvms.15-0711
  • NAID: 130005159665
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access
• [Journal Article] Synovial fluid total protein concentration as a possible marker for canine idiopathic polyarthritis (2015)
  • Author(s): Murakami K, Yonezawa T, Matsuki N.
  • Journal Title: Journal of Veterinary Medical Science Volume: 77 Issue: 12 Pages: 1715-1717
  • DOI: 10.1292/jvms.15-0263
  • NAID: 130005115336
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access
• [Presentation] Syngeneic ANXA5 inhibition of mammary tumor cell growth in the dog (2017)
  • Author(s): Mona Uchida, Kohei Saeki, Shingo Maeda, Tomohiro Yonezawa, Naoaki Matsuki and Mitsumori Kawaminami
  • Organizer: Annexin Conference 2017
  • Int'l Joint Research
• [Presentation] Relationship between lunar cycle and spontaneous delivery date in Holstein cows (2017)
  • Author(s): Tomohiro Yonezawa, Dai Ishiyama, Mona Uchida, Michiko Tomioka, Kazunori Ishii, Shizuko Maeda, Yoji Sasai, Masatsugu Asada, Tadashi Kawamura, Yoshihiro Nakamura, Eimei Sato, Shingo Maeda, Naoaki Matsuki
  • Organizer: WCRB2017
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 腫瘍の治療剤およびその使用 (2016)
  • Inventor(s): 米澤智洋、内田萌菜、松木直章、金村優香、川上和夫
  • Industrial Property Rights Holder: 米澤智洋、内田萌菜、松木直章、金村優香、川上和夫
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-05-26
  • Overseas