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The role of canine AIM in histiocytic sarcoma(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0275
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Yonezawa Tomohiro  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10433715)

Research Collaborator Ruffell Brian  Moffitt cancer research center
Project Period (FY) 2016 – 2017
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsマクロファージ / 組織球性肉腫 / 犬 / アポトーシス / 抗体 / がん免疫 / 獣医学 / 内科
Outline of Final Research Achievements

Tumor-associated macrophage (TAM) is reported to be closely related to malignancy of tumorgenesis. However, it is unknown how macrophage can transverse into TAM. We have focused on a specific protein, apoptosis inhibitor of macrophage (AIM), which is expressed in macrophages. In this study, it is found that AIM is highly expressed in TAM and AIM inhibited apoptosis of these cells in vitro. It is also found that AIM could bind some factor of apoptosis pathway, suggesting that AIM should inhibit apoptosis via binding it.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

Research Products

(14 results)

All 2018 2017 2016

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Moffitt Cancer Center(米国)2016

    • Year and Date
      2016-10-01
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Presence of contagious yawning in sheep2018

    • Author(s)
      Yonezawa Tomohiro、Sato Kohei、Uchida Mona、Matsuki Naoaki、Yamazaki Atusi
    • Journal Title

      Anim Sci J.

      Volume: 88 Pages: 195-200

    • DOI

      10.1111/asj.12681

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoscopic Cytology for the Diagnosis of Chronic Enteritis and Intestinal Lymphoma in Dogs2017

    • Author(s)
      Maeda S.、Tsuboi M.、Sakai K.、Ohno K.、Fukushima K.、Kanemoto H.、Hiyoshi-Kanemoto S.、Goto-Koshino Y.、Chambers J. K.、Yonezawa T.、Uchida K.、Matsuki N.
    • Journal Title

      Vet Pathol.

      Volume: 54 Pages: 595-604

    • DOI

      10.1177/0300985817705175

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Density of tumor-infiltrating granzyme B-positive cells predicts favorable prognosis in dogs with transitional cell carcinoma2017

    • Author(s)
      Inoue Akiko、Maeda Shingo、Kinoshita Ryohei、Tsuboi Masaya、Yonezawa Tomohiro、Matsuki Naoaki
    • Journal Title

      Veterinary Immunology Immunopathology

      Volume: 190 Pages: 53-56

    • DOI

      10.1016/j.vetimm.2017.07.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased plasma amino acid concentrations in cats with chronic gastrointestinal diseases and their possible contribution in the inflammatory response.2017

    • Author(s)
      Sakai K, Maeda S, Yonezawa T, Matsuki N.
    • Journal Title

      Vet Immunol Immunopathol.

      Volume: 195: Pages: 1-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fecal microbiome in dogs with inflammatory bowel disease and intestinal lymphoma.2017

    • Author(s)
      Omori M, Maeda S, Igarashi H, Ohno K, Sakai K, Yonezawa T, Horigome A, Odamaki T, Matsuki N.
    • Journal Title

      J Vet Med Sci.

      Volume: 79(11) Pages: 1840-1847

    • NAID

      130006206562

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cycle Influences Spontaneous Delivery in Cows.2016

    • Author(s)
      Yonezawa T, Uchida M, Tomioka M, Matsuki N
    • Journal Title

      PLoS One

      Volume: 11(8)

    • DOI

      10.1371/journal.pone.0161735

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines2016

    • Author(s)
      Uchida M, Saeki K, Maeda S, Tamahara S, Yonezawa T, Matsuki N
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 78(9) Issue: 9 Pages: 1515-1520

    • DOI

      10.1292/jvms.16-0120

    • NAID

      130005598036

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prolactin suppression of Gonadotropin releasing hormone initiation of mammary gland involution in female rats.2016

    • Author(s)
      Rieanrakwong D, Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Hasegawa Y, Kawaminami M.
    • Journal Title

      Endocrinology

      Volume: 157(7) Pages: 2750-2758

    • DOI

      10.1210/en.2016-1180

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synovial fluid matrix metalloproteinase-2 and -9 activities in dogs suffering from joint disorders2016

    • Author(s)
      Murakami K, Maeda S, Yonezawa T, Matsuki N
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 78(6) Issue: 6 Pages: 1051-1054

    • DOI

      10.1292/jvms.15-0711

    • NAID

      130005159665

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synovial fluid total protein concentration as a possible marker for canine idiopathic polyarthritis2016

    • Author(s)
      Murakami K, Yonezawa T, Matsuki N.
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 77(12) Issue: 12 Pages: 1715-1717

    • DOI

      10.1292/jvms.15-0263

    • NAID

      130005115336

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Syngeneic ANXA5 inhibition of mammary tumor cell growth in the dog2017

    • Author(s)
      Mona Uchida, Kohei Saeki, Shingo Maeda, Tomohiro Yonezawa, Naoaki Matsuki and Mitsumori Kawaminami
    • Organizer
      Annexin Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between lunar cycle and spontaneous delivery date in Holstein cows2017

    • Author(s)
      Tomohiro Yonezawa, Dai Ishiyama, Mona Uchida, Michiko Tomioka, Kazunori Ishii, Shizuko Maeda, Yoji Sasai, Masatsugu Asada, Tadashi Kawamura, Yoshihiro Nakamura, Eimei Sato, Shingo Maeda, Naoaki Matsuki
    • Organizer
      WCRB2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 腫瘍の治療剤およびその使用2016

    • Inventor(s)
      米澤智洋、内田萌菜、松木直章、金村優香、川上和夫
    • Industrial Property Rights Holder
      米澤智洋、内田萌菜、松木直章、金村優香、川上和夫
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-05-26
    • Related Report
      2016 Research-status Report
    • Overseas

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Published: 2016-10-04   Modified: 2019-03-29  

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