Assessment of the impact of global warming on sex determination in coastal marine fish(Fostering Joint International Research)
| Project/Area Number |
15KK0277
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Aquatic bioproduction science
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
Yamamoto Yoji 東京海洋大学, 学術研究院, 助教 (10447592)
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| Project Period (FY) |
2016 – 2019
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Keywords | 地球温暖化 / 気候変動 / 指標生物 / 温度依存型性決定機構 / 遺伝型性決定機構 / 性転換 / トウゴロウイワシ / トウゴロウイワシ目魚類 / 性分化 / 温度依存型性決定 |
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| Outline of Final Research Achievements |
To reveal the mechanism of low water temperature-induced female sex reversal in fish, trascriptomic analysis was performed using gonadal mRNAs from normal (XX) and low temperature-induced sex reversed (XY) females. Ninety-nine genes (e.g., egfl6, capn1, calm1) were differentially expressed between the two groups during the sex determining period. Ingenuity Pathway Analysis (IPA) to predict biological pathways that underwent changes based on observed gonadal gene expression revealed that the top-three differential canonical pathways were calcium, protein kinase A, and opioid signaling. Upstream regulator analysis, which predicts regulators that caused observed gene expression, revealed several interesting factors such as beta-estradiol, estrogen receptor 1, and transforming growth factor beta 1. The fact that estrogen and TGF-beta signaling were highlighted by IPA suggests that these pathways may play a key role in feminizing effects of cooler temperatures on XY-genotype fish.
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| Academic Significance and Societal Importance of the Research Achievements |
本課題により、低水温により魚類の遺伝的雄（XY）を雌（卵巣）に性転換させるには、estrogenおよびTGF-βシグナル系が深く関わっていることが明らかとなった。本成果は、魚類のみならず、爬虫類等の他の脊椎動物における温度依存型性決定機構の全容解明、とりわけ低水温が誘起する遺伝的雄の性転換機構の解明に寄与すると期待される。また、魚類を含む脊椎動物の性決定機構の進化を解読するうえでも重要な分子基盤になると期待される。
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Evidence of a landlocked reproducing population of the marine pejerrey Odontesthes argentinensis (Actinopterygii; Atherinopsidae)2020
Author(s)
D.C. Colautti, L. Miranda, M. Gonzalez-Castro, V. Villanova, C.A. Strussmann, M. Mancini, T. Maiztegui, G. Berasain, R. Hattori, F. Grosman, P. Sanzano, I. Lozano, S.L. Vegh, V. Salinas, O. Del Ponti, P. del Fresno, P. Minotti, Y. Yamamoto, and C.R.M. Baigun
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Journal Title
Journal of Fish Biology
Volume: 96
Issue: 1
Pages: 202-216
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Temperature-dependent sex determination in wild cobaltcap silverside Hypoatherina tsurugae, an atherinid fish from the Northwest Pacific ocean2018
Author(s)
Yamamoto, Y., Miyoshi, K., Bej, Dilip., Hattori, R.S., Strussmann, C.A.
Organizer
8th International Symposium on Vertebrate Sex Determination
Related Report
Int'l Joint Research
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