The pathophysiological mechanisms between treatment-resistance mood disorder and insulin resistance(Fostering Joint International Research)

• Project/Area Number: 15KK0295
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: Narita Kosuke 群馬大学, 医学部附属病院, 講師 (70345677)
• Research Collaborator: Norhoff G Ottawa University, Mind and Brain Imaging, Research Chair
• Project Period (FY): 2015 – 2017
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 治療抵抗性気分障害 / power-law exponent / MRS-GABA / 気分障害 / 治療抵抗性 / 老年期うつ病 / インスリン抵抗性 / 脳機能画像 / GABA

Outline of Final Research Achievements

The scale-free dynamics of human brain activity, characterized by an elaborate temporal structure with scale-free properties, can be quantified using the power-law exponent (PLE) as an index. PLE modulation during cognitive-task-evoked activity and its relationship with an associated behavior remain unclear. We investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task, by fMRI. We found that face discrimination-induced BOLD signal changes in the medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), amygdala, and fusiform face area; PLE significantly decreased during task-evoked activity specifically in mPFC compared with resting state activity; most importantly, in mPFC, mRT significantly negatively correlated with both resting state PLE and the resting-task PLE difference.

Research Products

• [Int'l Joint Research] Ottawa University(カナダ) (2016)
  • Year and Date: 2016-04-01
• [Journal Article] γ-Aminobutyric acid type A receptor binding affinity in the right inferior frontal gyrus at resting state predicts the performance of healthy elderly people in the visual sustained attention test. (2018)
  • Author(s): Kasagi M, Motegi T, Narita K, Fujihara K, Suzuki Y, Tagawa M, Ujita K, Shimada H, Fukuda M.
  • Journal Title: Int Psychogeriatr Volume: 21 Issue: 9 Pages: 1-7
  • DOI: 10.1017/s1041610217002988
  • Peer Reviewed / Open Access
• [Journal Article] Association between Scale-Free Brain Dynamics and Behavioral Performance: Functional MRI Study in Resting State and Face Processing Task (2017)
  • Author(s): Kasagi Masato、Huang Zirui、Narita Kosuke、Shitara Hitoshi、Motegi Tomokazu、Suzuki Yusuke、Fujihara Kazuyuki、Tanabe Sean、Kosaka Hirotaka、Ujita Koichi、Fukuda Masato、Northoff Georg
  • Journal Title: Behav. Neurol. Volume: 2017 Pages: 1-9
  • DOI: 10.1155/2017/2824615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Association between Scale-Free Brain Dynamics and Behavioral Performance: Functional MRI Study in Resting State and Face Processing Task. (2017)
  • Author(s): Kasagi M, Huang Z, Narita K, Shitara H, Motegi T, Suzuki Y, Fujihara K, Tanabe S, Kosaka H, Ujita K, Fukuda M, Northoff G.
  • Organizer: 第19回日本ヒト脳機能マッピング学会
• [Funded Workshop] Neuroimaging meeting (2016)
  • Place of Presentation: Montreal
  • Year and Date: 2016-05-05
• [Funded Workshop] Neuroimaging meeting (2016)
  • Place of Presentation: Ottwa