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Development of a matter phase controlled Rn/At generator for targeted alpha therapy(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0301
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionFukushima Medical University (2017-2019)
Kanazawa University (2015-2016)

Principal Investigator

Washiyama Kohshin  福島県立医科大学, 公私立大学の部局等, 准教授 (80313675)

Project Period (FY) 2016 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywordsα放射体 / ジェネレータ / アスタチン-211 / アイソトープ治療 / 放射線 / がん / 薬学 / ラドン-211 / アルファ放射体 / 211At / α線内用療法
Outline of Final Research Achievements

211At is one of the α-emitters expected to be applied to radionuclide therapy in a field of nuclear medicine, but its use is limited to manufacturing sites because of its short half-life. In this study, 211Rn was manufactured in collaboration with Argonne National Laboratory and Duke University in the United States, which has clinical experience with 211At, in order to create a 211Rn/211At generator to support studies using 211At in remote areas. Under the collaboration work, we tried to manufacture the 211Rn by using 6Li beam of the tandem accelerator ATLAS. And we also evaluated the effects of the radiolysis in organic solvents using high activity 211At. As a result, we confirmed the production of 211Rn at Argone National Laboratory. Moreover, when extracting highly radioactive 211At from nitric acid solution to organic solvent, no phenomenon due to radiolysis was observed.

Academic Significance and Societal Importance of the Research Achievements

国際共同研究の下でGBq量の211Rnを製造し、本研究で開発するジェネレータを用いることで、211Atを製造拠点や半減期に依存することなく211Atを提供することが可能になり、世界各国のアイソトープ治療の拠点病院で211Atを用いた治療が可能になる。さらに、半減期と製造法に依存した供給体制のために研究が困難であった211Atが、広く希望する施設および研究者に提供されることで、At元素そのものに対する物理化学的性質がより明らかとなり、新しい現象や物性、およびそれに基づく生命科学・医療への応用の道が拓かれる。そして、海外の研究者にも日本における研究の状況が理解され、今後日本主体の共同研究を導く。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (30 results)

All 2020 2019 2018 2017 2016

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Open Access: 4 results,  Peer Reviewed: 4 results) Presentation (22 results) (of which Int'l Joint Research: 11 results,  Invited: 5 results)

  • [Int'l Joint Research] アルゴンヌ国立研究所(米国)2018

    • Year and Date
      2018-05-03
    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] デューク大学(米国)2016

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Current Status of alpha emitters useful for targeted radionuclide therapy2020

    • Author(s)
      鷲山幸信
    • Journal Title

      Drug Delivery System

      Volume: 35 Issue: 2 Pages: 102-113

    • DOI

      10.2745/dds.35.102

    • NAID

      130007864108

    • ISSN
      0913-5006, 1881-2732
    • Year and Date
      2020-03-25
    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] 1.The pharmacological properties of 3-arm or 4-arm DOTA constructs for conjugation to α-melanocyte-stimulating hormone analogues for melanoma imaging2018

    • Author(s)
      Kobayashi M, Kato T, Washiyama K, Ihara M, Mizutani A, Nishi K, Flores LG 2nd, Nishii R, Kawai K.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 3 Pages: e0213397-e0213397

    • DOI

      10.1371/journal.pone.0213397

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 2.Reduction of 223Ra retention in the Large Intestine during Targeted Alpha Therapy with 223RaCl2 by Oral BaSO4 Administration in Mice2018

    • Author(s)
      Hanadatea S, Yoshii Y, Washiyama K, Yoshimoto M, Yamamura T, Watanabe M, Matsumoto H, Igarashi M, Tsuji B A, Higashi T.
    • Journal Title

      International Journal of Sciences: Basic and Applied Research (IJSBAR)

      Volume: 42 Pages: 95-102

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a remotely operable digital rate meter for radiation monitoring2017

    • Author(s)
      Nakayama K, Kita J, Washiyama K.
    • Journal Title

      Wellness Health Care.

      Volume: 41 Pages: 159-166

    • NAID

      120006394953

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of iodine radionuclides using 7Li ion beams2017

    • Author(s)
      Nishinaka I, Yokoyama A, Washiyama K, Makii H, Hashimoto K.
    • Journal Title

      J Radioanal Nucl Chem.

      Volume: 314 Issue: 3 Pages: 1947-1965

    • DOI

      10.1007/s10967-017-5525-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 標的アイソトープ治療に対するα放射体からのアプローチ2016

    • Author(s)
      鷲山幸信
    • Journal Title

      放射線

      Volume: 41(4) Pages: 211-220

    • Related Report
      2016 Research-status Report
  • [Presentation] アルファ放射体を用いた標的アイソトープ治療(TRT)2019

    • Author(s)
      鷲山幸信
    • Organizer
      日本医学物理学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] An effort to diagnostic and therapeutic nuclear medicine at Fukushima Medical University using two medical cyclotrons2019

    • Author(s)
      Kohshin Washiyama
    • Organizer
      International Symposium on Trends in Radiopharmaceuticals (ISTR-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An effort to diagnostic and therapeutic nuclear medicine at Fukushima Medical University towards the clinical trials2019

    • Author(s)
      Kohshin Washiyama
    • Organizer
      KIRAMS International Symposium on Theranostics: Radioisotopes and Clinical Practice
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development and challenges of alpha-emitting radiopharmaceuticals2019

    • Author(s)
      Kohshin Washiyama
    • Organizer
      Korean Society of Radiopharmaceutical and Molecular Probes 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] アルファ放射体を用いた内用療法への取り組み2019

    • Author(s)
      鷲山幸信
    • Organizer
      日本核医学会分科会放射性薬品科学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ラドンの気相回収法とイオン液体抽出によるRn-Atジェネレーターシステムの開発2019

    • Author(s)
      川﨑 康平, 新 裕喜, 青井 景都, 東 美里, 鷲山 幸信, 西中 一朗, 横山 明彦
    • Organizer
      日本放射化学会第63回討論会(2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 211Rn/211At ジェネレータシステムに必要な207Poの除去法の検討2019

    • Author(s)
      青井 景都, 新 裕貴, 川﨑 康平, 東 美里, 鷲山 幸信, 西中 一朗, 羽場 宏光, 森 大輝, Yang Wang, 横山 明彦
    • Organizer
      日本放射化学会第63回討論会(2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Advanced Clinical Research Center of Fukushima Medical University: two cyclotrons installed facility for basic research and clinical application of medical radioisotopes2018

    • Author(s)
      Takahashi K, Tominaga H, Washiyama K, Nishijima K, Aoki M, Zhao S, Ukon N, Oriuchi N.
    • Organizer
      17th International Workshop on Targetry and Target Chemistry (WTTC17)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Initial Experiences on the Production of Astatine‐211 at Fukushima Medical University using “CYPRIS MP-30” Cyclotron.2018

    • Author(s)
      Oda T, Washiyama K, Aoki M, Taniguchi M, Kato J, Gomez FG, Ishizuka T, Takahashi K.
    • Organizer
      17th International Workshop on Targetry and Target Chemistry (WTTC17)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラドンガス密封シリンジを利用したRn-At ジェネレーターシステムの開発2018

    • Author(s)
      川﨑康平, 新 裕喜, 青井景都, 鷲山幸信, 西中一朗,羽場宏光, 矢納慎也, 横山明彦
    • Organizer
      第62回放射化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 中型サイクロトロンを用いた211At の製造と化学分離2018

    • Author(s)
      鷲山幸信, 粟生木美穂, 佐々木茂範, 小田敬, 西嶋剣一, 高橋和弘
    • Organizer
      第62回放射化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 211Rn-211At ジェネレーター開発のためのアスタチン溶媒抽出の研究 ―131I との抽出挙動の比較及び酸化剤の効果の調査―2018

    • Author(s)
      新裕喜,川崎康平,青井景都,横山明彦,鷲山幸信,西中一朗,矢納慎也,羽場宏光
    • Organizer
      第62回放射化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 225Ac/213Biと211Atの核薬学研究の最先端2018

    • Author(s)
      鷲山幸信
    • Organizer
      第58回日本核医学会学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 垂直照射法を用いた211Atの製造に関する諸条件の検討2018

    • Author(s)
      鷲山幸信, 小田敬, 佐々木茂範, 粟生木美穂, Francisco L. Guerra Gomez,谷口愛実, 西嶋剣一,高橋和弘
    • Organizer
      第58回日本核医学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Astatine-211の乾式分離法の検討2018

    • Author(s)
      鷲山幸信, 小田敬, 粟生木美穂, 佐々木茂範, 西嶋剣一,高橋和弘
    • Organizer
      第58回日本核医学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Wet chemistry processes utilized in the development of a 211Rn/211At generator for targeted alpha therapy2017

    • Author(s)
      Shin Y, Ooe S, Murakami K, Taniguchi T, Maeda E, Yamada N, Washiyama K, Yokoyama A, Nishinaka I
    • Organizer
      6th Asia-Pacific Symposium on Radiochemistry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optimization of 225Ac labeling to DOTA conjugated peptide for targeted alpha therapy2017

    • Author(s)
      Washiyama K, Kato K, Yamamura T, Yoshii Y, Yoshimoto M, Kobayashi M, Kawai K
    • Organizer
      ACITINIDES 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of method to reduce radiation exposure to the large intestine during 223Ra alpha therapy with barium sulfate2017

    • Author(s)
      Yoshii Y, Hanadate S, Washiyama K, Yoshimoto M, Matsumoto H, Yamamura T, Watanabe M, Tsuji AB, Higashi T.
    • Organizer
      ACITINIDES 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Stabillity constants of EDTA, DOTA, EDTMP and DOTMP complex with Th(IV) for nuclear medicine2017

    • Author(s)
      Kitabayashi K, Furuta M, Ohta S, Yamamura T, Washiyama K.
    • Organizer
      ACITINIDES 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Administration of barium sulfate reduces radiation exposure in the large intestine during alpha-therapy with radium-223-dichloride2017

    • Author(s)
      Hanadate S, Yoshii Y, Washiyama K, Yoshimoto M, Matsumoto H, Tsuji AB, Higashi T
    • Organizer
      SNMMI 2017 Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduction of radiation exposure to the large intestine during 223Ra alpha therapy with oral administration of barium sulfate2017

    • Author(s)
      Hanadate S, Washiyama K, Yoshimoto M, Matsumoto H, Tsuji AB, Higashi T, Yoshii Y
    • Organizer
      10th International Symposium on Targeted Alpha Therapy
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Wet chemistry of radon and astatine for the development of a 211Rn/211At generator2017

    • Author(s)
      Shin Y, Ooe S, Murakami K, Taniguchi T, Maeda E, Yamada N, Washiyama K, Yokoyama A.
    • Organizer
      10th International Symposium on Targeted Alpha Therapy
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-10-04   Modified: 2021-02-19  

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