| Project/Area Number |
15KK0312
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
OBA Makoto 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
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| Research Collaborator |
Huc Ivan European Institute for Chemistry and Biology, Group Leader
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| Project Period (FY) |
2015 – 2017
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Keywords | フォルダマー / 細胞膜透過性 / ヘリックス構造 / ドラッグデリバリー / 膜透過機能 / コンフォメーション / 有機化学 / 薬学 / バイオテクノロジー |
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| Outline of Final Research Achievements |
We designed and synthesized 8 hybrid foldamers composed of amino acids and quinoline derivatives. All hybrid foldamers adopted a right-handed helical structure independently of their structures of amino acids and quinoline derivatives. Cationic foldamers containing anionic amino acids formed aggregates and showed strong cell-penetrating ability compared to typical cell-penetrating peptide, Tat peptide. These findings will be helpful for design of de novo foldamers functioning as DDS carriers.
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