Development of cell-penetrating peptides and their application to DDS carriers(Fostering Joint International Research)

Research Project

Project/Area Number	15KK0312
Research Category	Fund for the Promotion of Joint International Research (Fostering Joint International Research)
Allocation Type	Multi-year Fund
Research Field	Drug development chemistry
Research Institution	Nagasaki University
Principal Investigator	OBA Makoto 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
Research Collaborator	Huc Ivan European Institute for Chemistry and Biology, Group Leader
Project Period (FY)	2015 – 2017
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Keywords	フォルダマー / 細胞膜透過性 / ヘリックス構造 / ドラッグデリバリー / 膜透過機能 / コンフォメーション / 有機化学 / 薬学 / バイオテクノロジー
Outline of Final Research Achievements	We designed and synthesized 8 hybrid foldamers composed of amino acids and quinoline derivatives. All hybrid foldamers adopted a right-handed helical structure independently of their structures of amino acids and quinoline derivatives. Cationic foldamers containing anionic amino acids formed aggregates and showed strong cell-penetrating ability compared to typical cell-penetrating peptide, Tat peptide. These findings will be helpful for design of de novo foldamers functioning as DDS carriers.