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Natural history of the people having radiographic LSS and its predictive factor(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0316
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionWakayama Medical University

Principal Investigator

Ishimoto Yuyu  和歌山県立医科大学, 医学部, 博士研究員 (20508030)

Project Period (FY) 2016 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
KeywordsMRI / 腰部脊柱管狭窄症 / 疫学 / 腰椎すべり / 職業 / 自動解析 / 疫学研究 / 腰椎すべり症 / 変性腰椎症 / 危険因子 / 腰部脊柱管狭窄 / 変性腰椎 / 腰痛 / 下肢痛 / 脊椎 / 腰 / 退行性変化 / 整形外科
Outline of Final Research Achievements

I studied in the MRC epidemiology unit in Southampton University, the UK with this fund in 2017-2018. I clarified the association of LSS, lumbar spondylolisthesis with their occupation.  I also reported the reproducibility the MRI grading between the new device which was developed by Prof. Fairbank, Oxford University, and I. I became the member of 'Spine Net' ,which was established in 2011 in order to develop the new device for lumbar MRI grading for research of low back pain.

Academic Significance and Societal Importance of the Research Achievements

ロコモティブシンドロームの3大原因疾患のひとつである腰部脊柱管狭窄症(LSS)は、本邦に600万人ほど存在すると推定されているもののその予防についての研究はほとんどされていない。本コホートstudyでは追跡調査を行うことで本疾患の危険因子を解明したいと考えている。申請者はMRI画像と症状の関係や、職業との関係について横断で報告した。またMRI自動解析装置についても、申請者のグレーディングとそれを学習した装置との再現性の精度の高さについて報告している。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2020 2019 2018 2017

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (9 results) (of which Int'l Joint Research: 7 results)

  • [Int'l Joint Research] サザンプトン大学MRC疫学センター(英国)2017

    • Year and Date
      2017-07-10
    • Related Report
      2019 Annual Research Report
  • [Journal Article] The New Strategy for the Treatment of Cerebrospinal Fluid Leak Following Lumbar Surgery2020

    • Author(s)
      Ishimoto Yuyu、Kawakami Mamoru、Curtis Elizabeth、Cooper Cyrus、Moriguchi Nami、Nakao Shin-ichi、Nakagawa Yukihiro
    • Journal Title

      Spine Surgery and Related Research

      Volume: 4 Issue: 1 Pages: 95-98

    • DOI

      10.22603/ssrr.2019-0037

    • NAID

      130007791229

    • ISSN
      2432-261X
    • Year and Date
      2020-01-27
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Could automated machine-learned MRI grading aid epidemiological studies of lumbar spinal stenosis? Validation within the Wakayama spine study2020

    • Author(s)
      Ishimoto Yuyu、Jamaludin Amir、Cooper Cyrus、Walker-Bone Karen、Yamada Hiroshi、Hashizume Hiroshi、Oka Hiroyuki、Tanaka Sakae、Yoshimura Noriko、Yoshida Munehito、Urban Jill、Kadir Timor、Fairbank Jeremy
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 21 Issue: 1 Pages: 158-158

    • DOI

      10.1186/s12891-020-3164-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Impact of Lumbar Spinal Stenosis, Knee Osteoarthritis, and Loss of Lumbar Lordosis on the Quality of Life: Findings from the Katsuragi Low Back Pain Study2019

    • Author(s)
      Ishimoto Yuyu、Kawakami Mamoru、Curtis Elizabeth、Cooper Cyrus、Harvey Nicholas C.、Westbury Leo、Teraguchi Masatoshi、Horie Kayoko、Nakagawa Yukihiro
    • Journal Title

      Spine Surgery and Related Research

      Volume: 3 Issue: 2 Pages: 157-162

    • DOI

      10.22603/ssrr.2018-0051

    • NAID

      130007639211

    • ISSN
      2432-261X
    • Year and Date
      2019-04-27
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the Wakayama spine study2019

    • Author(s)
      Ishimoto Yuyu、Cooper Cyrus、Ntani Georgia、Yamada Hiroshi、Hashizume Hiroshi、Nagata Keiji、Muraki Shigeyuki、Tanaka Sakae、Yoshida Munehito、Yoshimura Noriko、Walker-Bone Karen
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 20 Issue: 1 Pages: 618-618

    • DOI

      10.1186/s12891-019-2994-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factory and construction work is associated with an increased risk of severe lumbar spinal stenosis on MRI: A case control analysis within the wakayama spine study2019

    • Author(s)
      Ishimoto Yuyu、Cooper Cyrus、Ntani Georgia、Yamada Hiroshi、Hashizume Hiroshi、Nagata Keiji、Muraki Shigeyuki、Tanaka Sakae、Yoshimura Noriko、Yoshida Munehito、Walker-Bone Karen
    • Journal Title

      American Journal of Industrial Medicine

      Volume: in press Issue: 5 Pages: 430-438

    • DOI

      10.1002/ajim.22957

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Succession of MRI Scans Supports the Diagnosis of Lumbar Ligamentum Flavum Hematoma: A Case Report and Review of the Literature2018

    • Author(s)
      Ishimoto Yuyu、Kawakami Mamoru、Curtis Elizabeth、Cooper Cyrus、Moriguchi Nami、Nakagawa Yukihiro
    • Journal Title

      Case Reports in Orthopedics

      Volume: 2018 Pages: 1-6

    • DOI

      10.1155/2018/2860621

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spinal Endoscopy for Delayed-Onset Lumbar Radiculopathy Resulting from Foraminal Stenosis after Osteoporotic Vertebral Fracture: A Case Report of a New Surgical Strategy2018

    • Author(s)
      Ishimoto Yuyu、Yamada Hiroshi、Curtis Elizabeth、Cooper Cyrus、Hashizume Hiroshi、Minamide Akihito、Nakagawa Yukihiro、Yoshida Munehito
    • Journal Title

      Case Reports in Orthopedics

      Volume: 2018 Pages: 1-4

    • DOI

      10.1155/2018/1593021

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] AUTOMATED MACHINE-LEARNED MRI GRADING FOR LUMBAR SPINAL STENOSIS IN THE WAKAYAMA SPINE STUDY2019

    • Author(s)
      Yuyu Ishimoto
    • Organizer
      JASMISS(第22回日本低侵襲脊椎外科学会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lumbar spinal stenosis, knee osteoarthritis and loss of lumbar lordosis have an impact on quality of life: findings from the Katsuragi Low Back Pain Study2019

    • Author(s)
      Yuyu Ishimoto
    • Organizer
      ISSLS (国際腰痛学会)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Automation of MRI gradings to aid longitudinal studies of lumbar spinal stenosis in the Wakayama Spine Study2019

    • Author(s)
      Yuyu Ishimoto
    • Organizer
      ISSLS (国際腰痛学会)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The new strategy for the treatment of cerebrospinal fluid leakage following lumbar surgery2019

    • Author(s)
      Yuyu Ishimoto
    • Organizer
      第48回 日本脊椎脊髄病学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Seven cases of blood injection therapy for the treatment of cerebrospinal fluid leakage following lumbar surgery2019

    • Author(s)
      Yuyu Ishimoto
    • Organizer
      ISASS (International Society for the Advancement of Spine Surgery)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The influence of lumbar spinal stenosis, knee osteoarthritis and loss of lumbar lordosis on quality of life: findings from the Katsuragi Low Back Pain Study2019

    • Author(s)
      Yuyu Ishimoto
    • Organizer
      ISASS (International Society for the Advancement of Spine Surgery)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SEVERE LUMBAR SPINAL STENOSIS ON MRI SCANS IS RELATED WITH HEAVY MANUAL WORK: The Wakayama Spine Study2018

    • Author(s)
      Ishimoto Yuyu
    • Organizer
      Bone Research Society in Winchester
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] HEAVY MANUAL WORK IS ASSOCIATED WITH AN INCREASED RISK OF SEVERE LUMBAR SPINAL STENOSIS ON MRI SCANS2018

    • Author(s)
      Ishimoto Yuyu
    • Organizer
      The International Society for the Study of the Lumbar Spine in Banff
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] RISK OF SEVERE LUMBAR SPINAL STENOSIS ON MRI SCANS IS INCREASED BY HEAVY MANUAL WORK: The Wakayama Spine Study2018

    • Author(s)
      Ishimoto Yuyu
    • Organizer
      WCO IOF-EFCEO in Krakow
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2016-10-04   Modified: 2021-02-19  

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