Hepatic tumor and Nrf2 activation by impaired autophagy(Fostering Joint International Research)
Project/Area Number |
15KK0325
|
Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
|
Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
|
Research Institution | Tohoku University |
Principal Investigator |
Taguchi Keiko 東北大学, 医学系研究科, 講師 (20466527)
|
Research Collaborator |
Kensler Thomas W. ジョンズホプキンス大学, Environmental Health Science, 名誉教授
Columbano Amedeo カリアリ大学, Scienze Biomediche, 教授
Cuadrado Antonio マドリード自治大学, Bioquimica, 教授
|
Project Period (FY) |
2016 – 2018
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
|
Keywords | Nrf2 / 肝臓 / 化学発がん / 肝臓がん |
Outline of Final Research Achievements |
Nrf2 knockout rats were used to examine contribution of a transcription factor Nrf2 in three kinds of chemical hepatocarcinogenesis models. Partial hepatectomy and DNA extraction from tissue sections by laser capture microdissection were learned from Professor Amedeo Columbano in University of Cagliari, Italy. Keap1-independent Nrf2 activation was discussed with Professor Antonio Cuadrado in Autonomous University of Madrid in Madrid, Spain. Nrf2 activation in Aflatoxin B1-induced liver tumor models was discussed with Professor Thomas Kensler in Johns Hopkins University in Baltimore, USA.
|
Academic Significance and Societal Importance of the Research Achievements |
アメリカ・イタリア・スペインの3カ国において、最新のNrf2研究に携わる研究者と共に、3年にわたって本研究を遂行できたことは大変意義深い。古くから実験モデルとして確立している化学肝発がんモデルをNrf2欠失ラットに適用することで、Nrf2がいかに毒物に対する防御系に寄与しているかを示すことができた。また、発がんにはNrf2の体性変異を獲得した細胞が生存して増殖することが示唆され、ヒトがんにおけるNrf2の活性化を治療標的とする今後の研究が期待される。
|
Report
(4 results)
Research Products
(25 results)
-
-
[Int'l Joint Research] ピッツバーグ大学(米国)2017
Year and Date
2017-03-05 – 2017-03-09
Country Name
U.S.A.
Counterpart Institution
ピッツバーグ大学
Co-investigator Overseas
Thomas Kensler
Department
Pharmacol & Chem Biol
Job Title
教授
Change Date
2018年6月6日
Related Report
-
[Int'l Joint Research] マドリード自治大学(スペイン)2016
Year and Date
2016-10-15 – 2016-10-22
Country Name
SPAIN
Counterpart Institution
マドリード自治大学
Co-investigator Overseas
Antonio Cuadorado
Department
Bioquimica
Job Title
教授
Change Date
2018年6月6日
Related Report
-
[Int'l Joint Research] カリアリ大学(イタリア)2016
Year and Date
2016-06-04 – 2016-06-19
Country Name
ITALY
Counterpart Institution
カリアリ大学
Co-investigator Overseas
Amedeo Columbano
Department
Scienze Biomediche
Job Title
教授
Change Date
2018年6月6日
Related Report
-
-
-
-
-
[Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016
Author(s)
Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
-
Journal Title
Nature Commun
Volume: 7
Pages: 12030
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] Nrf2 activation-acquired Liver cancer2017
Author(s)
Keiko Taguchi, Masayuki Yamamoto
Organizer
Closed seminar at Profs. Bruce Freeman & Thomas Kensler’s laboratories in University of Pittsburgh
Place of Presentation
Pittsburgh, USA
Year and Date
2017-03-07
Related Report
Int'l Joint Research / Invited
-
-
-
-
-
-
-
-
-
-