| Project/Area Number |
15KK0327
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
Winnik Francoise M. モントリオール大学, 化学科, 教授
Maysinger Dusica マギル大学, 薬理治療学科, 教授
SUZUKI Makoto 東北大学, 大学院工学研究科, 教授 (60282109)
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| Project Period (FY) |
2015 – 2016
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | ナノキャリア / 刺激応答性 / スルホベタインポリマー / 温熱化学療法 / スルホベタインコポリマー / 細胞膜透過性 / ナノバイオ / 薬物キャリア |
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| Outline of Final Research Achievements |
Development of nanocarriers for cancer thermal chemotherapy was carried out by precise design of copolymers based on sulfobetaine monomer, having a pair of positively and negatively charged groups in the side chain. The modification position of sulfobetaine copolymers by anticancer drug, doxorubicine, was examined and substitution at the ω terminus of the polymer showed the most efficient internalization to cancer cells. In addition, the presence of carboxy group at the α-terminus was effective compared to that of other functional groups. These polymers can be efficiently internalized into nerve cells and glial cells, and rhodamine modification enhanced the selective localization to mitochondria without reduction of its metabolic activity. These findings will give us a guideline for further development of nanocarriers.
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