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Elucidation of the mechanism of eosinophil degranulation associated with cell death and its application to the evaluation of disease(Fostering Joint International Research)

Research Project

Project/Area Number 15KK0329
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionAkita University

Principal Investigator

Ueki Shigeharu  秋田大学, 医学系研究科, 准教授 (60361234)

Project Period (FY) 2016 – 2019
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Keywords好酸球 / ETosis / 脱顆粒 / ヒストン / DNA / 細胞外トラップ / アレルギー / 細胞死 / 免疫 / 炎症
Outline of Final Research Achievements

In this international collaborative study, the mechanisms that determine eosinophil cell death (ETosis) in allergic diseases and the relationship between ETosis and pathogenesis in actual inflammatory tissues were elucidated. In allergic bronchopulmonary aspergillosis, eosinophil ETosis occurs at the site of inflammation and the mechanism of pathogen-induced ETosis was clarified. In addition, the presence of ETosis in eosinophilic otitis media and eosinophilic rhinosinusitis was also demonstrated. Charcot-Leiden crystals, galectin-10, chemokines, and extracellular vesicles were shown to be possible markers of allergic disease. These results have been reported in international journals and may provide the basis for future therapeutic strategies.

Academic Significance and Societal Importance of the Research Achievements

アレルギー疾患は頻度が高く増加傾向にある。なかでも難治性の好酸球性炎症疾患は医療費でも大きな割合を占め、世界的な問題になっている。本研究結果は、種々の難治性疾患のメカニズムを好酸球の細胞生物学的側面から明らかにしたものである。既存の概念にはなかった好酸球の細胞死という新しい視点から病態を理解することで、将来的な疾患モニタリングや治療に向けた道筋となる研究である。成果は複数の論文として当該分野のトップジャーナルを含む定評のある国際誌に掲載され、国内・国際学会の招請講演、依頼総説などを多く受けており、学術的な反響も大きかった。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (57 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (20 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 18 results,  Open Access: 13 results) Presentation (34 results) (of which Int'l Joint Research: 7 results,  Invited: 11 results) Remarks (2 results)

  • [Int'l Joint Research] ハーバード大学(米国)2017

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Galectin‐10, the protein that forms Charcot‐Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils2020

    • Author(s)
      Melo Rossana C. N.、Wang Haibin、Silva Thiago P.、Imoto Yoshimasa、Fujieda Shigeharu、Fukuchi Mineyo、Miyabe Yui、Hirokawa Makoto、Ueki Shigeharu、Weller Peter F.
    • Journal Title

      Journal of Leukocyte Biology

      Volume: - Issue: 1 Pages: 139-149

    • DOI

      10.1002/jlb.3ab0220-311r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Critical role of CCL4 in eosinophil recruitment into the airway2019

    • Author(s)
      Kobayashi Yoshiki、Konno Yasunori、Kanda Akira、Yamada Yoshiyuki、Yasuba Hirotaka、Sakata Yoshiko、Fukuchi Mineyo、Tomoda Koichi、Iwai Hiroshi、Ueki Shigeharu
    • Journal Title

      Clinical & Experimental Allergy

      Volume: - Issue: 6 Pages: 853-860

    • DOI

      10.1111/cea.13382

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis2019

    • Author(s)
      Yamada Takechiyo、Miyabe Yui、Ueki Shigeharu、Fujieda Shigeharu、Tokunaga Takahiro、Sakashita Masafumi、Kato Yukinori、Ninomiya Takahiro、Kawasaki Yohei、Suzuki Shinsuke、Saito Hidekazu
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 74-74

    • DOI

      10.3389/fimmu.2019.00074

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of CD16-negative selection vs. MACSxpress system for isolation of blood eosinophils2019

    • Author(s)
      Fukuchi Mineyo、Ueki Shigeharu、Saito Hidekazu、Miyabe Yui、Konno Yasunori、Omokawa Ayumi、Saga Tomoo、Moritoki Yuki、Takeda Masahide、Yamada Takechiyo、Hirokawa Makoto
    • Journal Title

      Allergology International

      Volume: 68 Issue: Supplement.1 Pages: S11-S13

    • DOI

      10.1016/j.alit.2019.04.005

    • NAID

      130007709782

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Severe Eosinophilic Disorders: Mechanisms and Clinical Management2019

    • Author(s)
      Akuthota Praveen、Neves Josiane S.、Ueki Shigeharu
    • Journal Title

      Frontiers in Immunology

      Volume: 10

    • DOI

      10.3389/fimmu.2019.02118

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report2019

    • Author(s)
      Kuwahara Toshiaki、Kobayashi Yoshiki、Yun Yasutaka、Kanda Akira、Asako Mikiya、Ueki Shigeharu、Iwai Hiroshi
    • Journal Title

      Allergy & Rhinology

      Volume: 10 Pages: 1177-1177

    • DOI

      10.1177/2152656719869607

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Charcot-Leyden Crystals in Eosinophilic Inflammation: Active Cytolysis Leads to Crystal Formation2019

    • Author(s)
      Shigeharu Ueki, Yui Miyabe, Yohei Yamamoto, Mineyo Fukuchi, Makoto Hirokawa, Lisa A. Spencer, Peter F. Weller
    • Journal Title

      Curr. Allergy Asthma Rep

      Volume: 19 Issue: 8 Pages: 38-38

    • DOI

      10.1007/s11882-019-0868-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Eosinophil Extracellular Traps and Inflammatory Pathologies?Untangling the Web!2018

    • Author(s)
      Mukherjee Manali、Lacy Paige、Ueki Shigeharu
    • Journal Title

      Frontiers in Immunology

      Volume: 9

    • DOI

      10.3389/fimmu.2018.02763

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-drug antibodies against a novel humanized anti-CD20 antibody impair its therapeutic effect on primary biliary cholangitis in human CD20- and FcγR-expressing mice2018

    • Author(s)
      Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M.
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Issue: NOV Pages: 2534-2534

    • DOI

      10.3389/fimmu.2018.02534

    • NAID

      120006937682

    • URL

      https://localhost/en/publications/edbe0baa-6e96-45b0-acf6-7a83123efd39

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Topical 3-bromopyruvate is a novel targeted therapy for melanoma in a preclinical model2018

    • Author(s)
      Yamada M, Kagaya M, Noguchi N, Ueki S, Hasunuma N, Osada SI, Manabe M.
    • Journal Title

      J Dermatol Sci

      Volume: 92 Issue: 2 Pages: 134-142

    • DOI

      10.1016/j.jdermsci.2018.08.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death2018

    • Author(s)
      Ueki Shigeharu、Tokunaga Takahiro、Melo Rossana C. N.、Saito Hidekazu、Honda Kohei、Fukuchi Mineyo、Konno Yasunori、Takeda Masahide、Yamamoto Yohei、Hirokawa Makoto、Fujieda Shigeharu、Spencer Lisa A.、Weller Peter F.
    • Journal Title

      Blood

      Volume: 132 Issue: 20 Pages: 2183-2187

    • DOI

      10.1182/blood-2018-04-842260

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ICAM-1 upregulation is not required for retinoic acid-induced human eosinophil survival2018

    • Author(s)
      Ueki Shigeharu、Nishikawa Junko、Fukuchi Mineyo、Konno Yasunori、Takeda Masahide、Moritoki Yuki、Chihara Junichi、Omokawa Ayumi、Saga Tomoo、Hirokawa Makoto
    • Journal Title

      Immunology Letters

      Volume: 196 Pages: 68-73

    • DOI

      10.1016/j.imlet.2018.01.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus2018

    • Author(s)
      Muniz Valdirene S.、Silva Juliana C.、Braga Yasmim A.V.、Melo Rossana C.N.、Ueki Shigeharu、Takeda Masahide、Hebisawa Akira、Asano Koichiro、Figueiredo Rodrigo T.、Neves Josiane S.
    • Journal Title

      Journal of Allergy & Clinical Immunology

      Volume: 141 Issue: 2 Pages: 571-585.e7

    • DOI

      10.1016/j.jaci.2017.07.048

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lytic eosinophils produce extracellular DNA traps as well as free eosinophil granules2018

    • Author(s)
      Persson Carl、Ueki Shigeharu
    • Journal Title

      J Allergy Clin Immunol

      Volume: 141 Issue: 3 Pages: 1164-1164

    • DOI

      10.1016/j.jaci.2017.05.047

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ETosis-derived DNA trap production in middle ear effusion is a common feature of eosinophilic otitis media2018

    • Author(s)
      Ohta N, et al
    • Journal Title

      Allergology International

      Volume: 67 Issue: 3 Pages: 414-416

    • DOI

      10.1016/j.alit.2017.11.007

    • NAID

      130007420530

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mucus plugging in allergic bronchopulmonary aspergillosis: Implication of the eosinophil DNA traps2018

    • Author(s)
      Omokawa Ayumi、Ueki Shigeharu、Kikuchi Yuta、Takeda Masahide、Asano Mariko、Sato Kazuhiro、Sano Masaaki、Ito Hiroshi、Hirokawa Makoto
    • Journal Title

      Allergology International

      Volume: 67 Issue: 2 Pages: 280-282

    • DOI

      10.1016/j.alit.2017.08.002

    • NAID

      130006721874

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] アレルギー・好酸球性炎症の病態解明2017

    • Author(s)
      植木重治
    • Journal Title

      Akita J Med

      Volume: 44 Pages: 11-17

    • NAID

      120006344054

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 好中球と好酸球のExtracellular trap cell death2017

    • Author(s)
      植木重治,今野泰典,廣川 誠
    • Journal Title

      分子呼吸器病

      Volume: 21 Pages: 12-15

    • Related Report
      2017 Research-status Report
  • [Journal Article] 好酸球の新しい細胞死:ETosis2017

    • Author(s)
      竹田正秀,植木重治, 廣川誠
    • Journal Title

      アレルギー・免疫

      Volume: 24 Pages: 48-53

    • Related Report
      2017 Research-status Report
  • [Journal Article] Eosinophilic Otitis Media: the Aftermath of Eosinophil Extracellular Trap Cell Death.2017

    • Author(s)
      Ueki S, Ohta N, et al
    • Journal Title

      Curr Allergy Asthma Rep

      Volume: 17 Issue: 5 Pages: 33-37

    • DOI

      10.1007/s11882-017-0702-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 好酸球の運命からみたECRSの病態2019

    • Author(s)
      植木重治
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 管腔内好酸球増多をきたす疾患群と好酸球の運命2019

    • Author(s)
      植木重治
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 組織における好酸球活性化の評価―細胞崩壊(cytolysis/ETosis)の免疫染色による検出2019

    • Author(s)
      福地峰世,植木重治,上出庸介,宮部 結,今野泰典,竹田正秀,面川 歩,嵯峨知生,守時由起,谷口正実,廣川 誠
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Charcot-Leyden crystal formation is mediated through eosinophil ETosis2019

    • Author(s)
      Fukuchi, M., Ueki, S., Takeda, M., Miyabe, Y., Konno, Y., Yamamoto, Y., Omokawa, A., Saga, T., Hirokawa, M., Melo, R.C.N., Weller, P.F.
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞死を起点とする好酸球性炎症2019

    • Author(s)
      植木重治
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 好酸球活性化に着目した炎症評価の課題2019

    • Author(s)
      植木重治
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 真菌と上気道炎症性疾患2019

    • Author(s)
      山田武千代,齋藤秀和,宮部 結,植木重治
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 好酸球ETosisに着目したシャルコー・ライデン結晶の病理学的検討2019

    • Author(s)
      齋藤秀和,植木重治,福地峰世,徳永貴広,今野泰典,山本洋平,宮部 結,山田武千代,廣川 誠
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] in vitroにおけるシャルコー・ライデン結晶の形成機構2019

    • Author(s)
      竹田正秀,植木重治,福地峰世,宮部 結,面川 歩,嵯峨知生,守時由起,佐藤一洋,佐野正明,中山勝敏,廣川 誠
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 著明な組織内シャルコー・ライデン結晶を認めた好酸球増多症候群患者2019

    • Author(s)
      福地峰世,植木重治,山本洋平,奈良美保,今野泰典,面川 歩,嵯峨知生,守時由起,大森泰文,高橋直人,廣川 誠
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 慢性肉芽腫症患者における好中球と好酸球のETosis2019

    • Author(s)
      植木重治,福地峰世,矢野道広,宮部 結,村長 萌,面川 歩,嵯峨亜希子,嵯峨知生,守時由起,高橋 勉,廣川 誠
    • Organizer
      第1回日本アレルギー学会東北地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 好酸球の行く末と好酸球性気道疾患の病態2019

    • Author(s)
      植木重治
    • Organizer
      第82回日本呼吸器学会 日本結核病学会 九州支部春季学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Eosinophil Extracellular Traps(EETs):好酸球の新しい機能2019

    • Author(s)
      植木重治
    • Organizer
      第6回総合アレルギー講習会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Eosinophil ETosis and Extracellular Chromatin Traps: A New Look at Eosinophilic Inflammation2019

    • Author(s)
      Ueki, S., Weller, P
    • Organizer
      11th Biennial Symposium of the International Eosinophil Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How to visualize ETosis-derived eosinophil extracellular traps2019

    • Author(s)
      Ueki, S., Fukuchi, M., Omokawa, A., Saga, T., Miyabe, Y., Takeda, M., Saito, H., Moritoki, Y., Yamada, T., Hirokawa, M., Melo, R., Weller, P
    • Organizer
      11th Biennial Symposium of the International Eosinophil Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] First Ultrastructural Demonstration of Galectin-10 in Resting and Activated Human Eosinophils2019

    • Author(s)
      Melo, R., Wang, H., Ueki, S. Weller, P.
    • Organizer
      11th Biennial Symposium of the International Eosinophil Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of Eosinophil Cytolytic Degranulation in Paraffin-Embedded Tissue2019

    • Author(s)
      Fukuchi, M., Ueki, S., Tan, N., Kamide, Y., Omokawa, A., Saga, T., Saito, H., Yamada, T., Moritoki, Y., Taniguchi, M., Hirokawa, M
    • Organizer
      11th Biennial Symposium of the International Eosinophil Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aspergillus Fumigatusによる好酸球ETosisの誘導機構2018

    • Author(s)
      植木重治,Josiane Naves,竹田正秀,福地峰世,今野泰典,蛇澤 晶,浅野浩一郎,廣川 誠
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症の粘液栓における好酸球Extracellular traps2018

    • Author(s)
      竹田正秀,植木重治,福地峰世,今野泰典,面川 歩,嵯峨知生,嵯峨亜希子,守時由起,廣川 誠,蛇澤 晶,浅野浩一郎
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 管腔内好酸球増多 (luminal eosinophilia) をきたす疾患群とETosis2018

    • Author(s)
      植木重治
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 好酸球性中耳炎におけるeosinophil extracellular DNA trap cell death(EETosis)2018

    • Author(s)
      太田伸男,植木重治,長舩大士,鈴木立俊,鈴木祐輔,高梨芳崇,藤枝重治
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] アレルギー性気管支炎肺アスペルギルス症の粘液栓への好酸球ETosis の関与2018

    • Author(s)
      竹田正秀,植木重治,Neves Josiane,福地峰世,今野泰典,佐藤一洋,佐野正明,廣川 誠,蛇澤 晶,浅野浩一郎
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好酸球増多を伴ったIgG4関連鼻副鼻腔炎の1例2018

    • Author(s)
      桑原敏彰,小林良樹,神田 晃,尾崎吉郎,植木重治,村田英之,朝子幹也,岩井 大
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ECRS 鼻茸組織中の活性化好酸球はMIP-1βを発現する2018

    • Author(s)
      尹 泰貴,小林良樹,Dan Bui Van,朝子幹也,植木重治,神田 晃,岩井 大
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 20分で末梢血から好酸球を分離するMACSxpressの性能評価2018

    • Author(s)
      福地峰世,植木重治,斎藤秀和,面川 歩,嵯峨亜希子,嵯峨知生,山田武千代, 廣川 誠
    • Organizer
      第67回日本アレルギー学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好酸球のETosisによるシャルコー・ライデン結晶の形成2018

    • Author(s)
      植木重治,竹田正秀,面川 歩,嵯峨知生,守時由起,鎌田由美子,廣川 誠
    • Organizer
      第65回日本臨床検査医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 注目されている免疫細胞・メディエーター 顆粒球(好中球・好酸球・好塩基球)2018

    • Author(s)
      植木重治
    • Organizer
      第5回総合アレルギー講習会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] MACSxpressにより高純度分離した好酸球の機能評価2018

    • Author(s)
      植木重治,福地峰世,齋藤秀和,竹田正秀,面川 歩,嵯峨亜希子,嵯峨知生,山田武千代,廣川 誠
    • Organizer
      アレルギー・好酸球研究会2018
    • Related Report
      2018 Research-status Report
  • [Presentation] PI3K/MAPK blockcade inhibits eosinophil extracellular trap cell death2017

    • Author(s)
      Ueki, S., Konno, Y., Omokawa, A., Saga, T., Takeda, M., Moritoki, Y., Hirokawa, M.
    • Organizer
      10th Biennial Symposium of the International Eosinophil Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Eosinophils and Aspergillus fumigatus infection: a DNA trap release story2017

    • Author(s)
      Muniz, VS., Silva, JC., Braga, YAV., Melo, RCN., Ueki, S., Takeda, M., Hebisawa, A., Asano, K., Figueiredo, RT., Neves, JS.
    • Organizer
      10th Biennial Symposium of the International Eosinophil Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Eosinophil extracellular traps are abundant in the bronchial mucus plugs of patients with ABPA2017

    • Author(s)
      Fukuchi, M., Ueki, S., Takeda, M., Omokawa, A., Saga, T., Hebisawa, A., Asano, K., Neves, J., Hirokawa, M.
    • Organizer
      29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ABPA患者の粘液栓におけるextracellular traps(ETs)の証明2017

    • Author(s)
      竹田正秀, 植木重治, 福地峰世, 面川歩, 嵯峨知生, 蛇澤晶, 浅野浩一郎, 廣川誠
    • Organizer
      アレルギー・好酸球研究会2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 活性化したヒト好酸球から産生される細胞外小胞の特徴2017

    • Author(s)
      植木重治,竹田正秀,面川歩,嵯峨知生,廣川誠
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト好酸球から産生されるextracellular microvesicles2017

    • Author(s)
      植木重治,竹田正秀,中村由夏,丹 典子,廣川 誠, Akuthota P, Rossana CNM
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Research-status Report
  • [Remarks] アレルギー・好酸球性炎症の研究

    • URL

      http://www.med.akita-u.ac.jp/~gimclm/research.html

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2017 Research-status Report
  • [Remarks] 細胞の自爆で体内に結晶ができる?

    • URL

      https://academist-cf.com/journal/?p=8810

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2016-10-04   Modified: 2021-02-19  

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