| Project/Area Number |
15KK0330
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
XU DOONGZHU 筑波大学, 医学医療系, 助教 (20616651)
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| Research Collaborator |
Chen Peng-Sheng Indiana University School of Medicine, Krannert Institute of Cardiology, 教授
Chen Zhenhui Indiana University School of Medicine, Krannert Institute of Cardiology, 准教授
Murakoshi Nobuyuki 筑波大学, 医学医療系, 講師
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| Project Period (FY) |
2016 – 2017
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Keywords | 心房細動 / Nampt / カルシウムハンドリング / 肥満 / 加齢 / atrial fibrillation / obesity / hampt / 心臓電気生理 / Nampt/NAD+/Sirtuin系 / カルシウム調節 |
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| Outline of Final Research Achievements |
Ncotinamide Phosphoribosyltransferase(Nampt) is a rate-limiting NAD+ biosynthetic enzyme known to decrease in adipose tissue of obese and aged rodents and people, Atrial Fibrillation is the most popular arrhythmia in the world and it is highly influenced by the obesity and aging. Nampt+/- mice and high fat diet mice showed increased AF inducibility and increased AF duration time compared to the control group. The mRNA and protein expression of Nampt, Sirt1, ATP2A2, PLN and RYR2 is altered.Conclusion: Nampt inhibition and high fat diet facilitates AF occurrence and increased induced AF duration by altering calcium handling pathway.
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