Mechanism of transcriptional regulation via skeletal muscle glucocorticoid receptor(Fostering Joint International Research)
| Project/Area Number |
15KK0332
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
Ruas Jorge Lira スウェーデン王立カロリンスカ研究所, 生理学薬理学部門, 准教授
MARUYAMA Takako 東京大学, 医科学研究所, 学術支援専門職員
KURIBARA Akiko 東京大学, 医科学研究所, 臨床検査技師
YOSHIKAWA Noritada 東京大学, 医科学研究所, 講師
Thissen Jean-Paul ベルギー王国ルーヴァン-カトリック大学, 医学部, 教授
TANAKA Hirotoshi 東京大学, 医科学研究所, 教授
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| Project Period (FY) |
2015 – 2017
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Keywords | メカノバイオロジー / レジスタンスエクササイズ / 筋肥大 / PGC1 / 核内受容体 / アトロジーン / 肥満 / ステロイド / 発現制御 / 生理学 / 生活習慣病 / 創薬 |
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| Outline of Final Research Achievements |
Regulation of skeletal muscle protein metabolism by the glucocorticoid (GC) -glucocorticoid receptor (GR) axis plays an important role in individual-level energy substance control through skeletal muscle-liver-adipose tissue cooperation. In this study, we analyzed the role played by PGC1alpha4, a key factor of muscle hypertrophy due to muscle load, in this mechanism. Using skeletal muscle under forced expression of PGC1alpha4, skeletal muscle specific PGC1alpha4 transgenic mice administered with synthetic glucocorticoid, and mouse skeletal muscle with muscle hypertrophy induced by resistance exercise training, we identified gene candidate groups showing common expression and characteristic expression.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation2018
Author(s)
K. Anan, S. Hino, N. Shimizu, A. Sakamoto, K. Nagaoka, R. Takase, K. Kohrogi, H. Araki, Y. Hino, S. Usuki, S. Oki, H. Tanaka, K. Nakamura, F. Endo, and M. Nakao
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Journal Title
Nucleic Acids Res.
Volume: 18
Issue: 11
Pages: 5441-5454
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure2017
Author(s)
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 39752-39752
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The effects of bolus supplementation of branched-chain amino acids on skeletal muscle mass, strength, and function in patients with rheumatic disorders during glucocorticoid treatment2016
Author(s)
Yoshikawa N, Shimizu N (equal first author), Uehara M, Oda A, Matsumiya R, Matsubara E, Kobayashi H, Hosono O, Kuribara-Souta A, Baba H, Nagamura F, Kiryu S, Tanaka H
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Journal Title
Modern Rheumatology
Volume: Epub ahead of print
Issue: 3
Pages: 508-517
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] ステロイド筋症に対する分岐鎖アミノ酸の効果に関する検討2016
Author(s)
吉川賢忠, 上原昌晃, 小田彩, 松宮遼, 小林弘, 松原絵里佳, 細野治, 清水宣明, 栗原明子, 馬場洋行, 桐生茂, 田中廣壽
Organizer
第89回日本内分泌学会学術総会
Place of Presentation
国立京都国際会館（京都府京都市）
Related Report
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[Presentation] リウマチ膠原病患者におけるステロイド筋症に対する分岐鎖アミノ酸投与の効果に関する検討2016
Author(s)
吉川賢忠, 上原昌晃, 小田彩, 細野治, 松原絵里佳, 馬場洋行, 栗原明子, 清水宣明, 丸山崇子, 江里俊樹, 田坂有希, 桐生茂, 田中廣壽
Organizer
第2回日本筋学会学術集会
Place of Presentation
国立研究開発法人 国立精神・神経医療研究センター（東京都小平市）
Related Report
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[Presentation] アンドロゲンによる骨格筋増強機構の解明2016
Author(s)
榊原伊織, 清水宣明, 上住聡芳, 深田 宗一朗, 田中廣壽, 今井祐記
Organizer
第39回日本分子生物学会年会（シンポジウム『核内受容体バイオロジー』）
Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Related Report
Invited
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