| Project/Area Number |
15KK0346
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Research Collaborator |
Titze Jens Vanderbilt大学, Department of Clinical Pharmacology, 教授
Wiig Helge Bergen大学, The Department of Biomedicine, 教授
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| Project Period (FY) |
2016 – 2017
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Keywords | 敗血症 / 急性腎障害 / Acute kidney injury |
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| Outline of Final Research Achievements |
The project examined the mechanism for the onset of septic acute kidney injury (AKI). The study explored that the pattern-recognition receptors in the proximal tubules plays essential roles for the early-phase changes of lipopolysaccharide-induced AKI. Triggering this mechanism induced early-phase AKI; however, it works as a compensatory protective factor against the further progression of AKI that is induced mainly by hemodynamic changes, including glomerular filtration decline. Monocyte/macrophage showed a contribution to the early phase AKI and the effect was either protective or deteriorative; active phagocyte population protected kidney against lipopolysaccharide-induced AKI, and monocytes/macrophage with poor phagocytic activity made AKI more severe.
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