exploring the mechanism of septic acute kidney injury(Fostering Joint International Research)

• Project/Area Number: 15KK0346
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Kagawa University
• Principal Investigator: Nakano Daisuke 香川大学, 医学部, 助教 (30524178)
• Research Collaborator: Titze Jens Vanderbilt大学, Department of Clinical Pharmacology, 教授 ; Wiig Helge Bergen大学, The Department of Biomedicine, 教授
• Project Period (FY): 2016 – 2017
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
• Keywords: 敗血症 / 急性腎障害 / Acute kidney injury

Outline of Final Research Achievements

The project examined the mechanism for the onset of septic acute kidney injury (AKI). The study explored that the pattern-recognition receptors in the proximal tubules plays essential roles for the early-phase changes of lipopolysaccharide-induced AKI. Triggering this mechanism induced early-phase AKI; however, it works as a compensatory protective factor against the further progression of AKI that is induced mainly by hemodynamic changes, including glomerular filtration decline. Monocyte/macrophage showed a contribution to the early phase AKI and the effect was either protective or deteriorative; active phagocyte population protected kidney against lipopolysaccharide-induced AKI, and monocytes/macrophage with poor phagocytic activity made AKI more severe.

Research Products

• [Int'l Joint Research] Vanderbilt University School of Medicine(米国) (2016)
  • Year and Date: 2016-08-30
• [Journal Article] Guanylyl cyclase A in both renal proximal tubular and vascular endothelial cells protects the kidney against acute injury in rodent experimental endotoxemia models. (2018)
  • Author(s): Kidney against Acute Injury in Rodent Experimental Endotoxemia Models. Kitamura H, Nakano D, Sawanobori Y, Asaga T, Yokoi H, Yanagita M, Mukoyama M, Tokudome T, Kangawa K, Shirakami G, Nishiyama A.
  • Journal Title: Anesthesiology Volume: 印刷中 Issue: 2 Pages: 296-310
  • DOI: 10.1097/aln.0000000000002214
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Renal capillary flow and hypoxia in kidney injury (2018)
  • Author(s): Daisuke Nakano
  • Organizer: ISN Frontiers meeting, Kidney disease & cardiovascular disease 2018
  • Int'l Joint Research / Invited
• [Presentation] LPS 誘導性急性腎障害において ANP は血管内皮細胞および近位尿細管細胞に作用し改善効果を示す (2017)
  • Author(s): 北村 裕亮、中野 大介、澤登 慶治、西山 成
  • Organizer: 第27回日本循環薬理学会