Novel therapeutic strategy based on precision medicine in bone and soft tissue sarcomas(Fostering Joint International Research)

• Project/Area Number: 15KK0353
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Juntendo University
• Principal Investigator: Suehara Yoshiyuki 順天堂大学, 医学部, 准教授 (70509405)
• Project Period (FY): 2016 – 2019
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
• Keywords: 骨軟部腫瘍 / 骨肉腫 / プレシジョンメディシン / がんクリニカルシークエンス / MSK-IMPACT / チロシンキナーゼ阻害剤 / MSK-IMAPCT / tyrosine kinase / 融合遺伝子 / 軟部肉腫 / 希少がん / プレシジョンメディスン / クリニカルシークエンス / 分子標的開発

Outline of Final Research Achievements

The prognosis of bone and soft tissue sarcomas are still extremely poor. As sarcomas is a rare cancer, the development of novel treatments has been delayed due to the limited amount of data and the associated negative efforts. In recent years, precision medicine based on a cancer clinical sequence, which uses a next-generation sequencer has been developed in across all cancer types. Additionally, in Japan, cancer gene panel tests were recently approved in government health care.
In this study, we mainly performed genome-based profiling of bone soft tissue sarcomas using MSK-IMPAC, which is a cancer clinical sequence and approved by FDA. These studies elucidated the frequency of potential actionable gene alteration based on OncoKB in each bone and soft tissue sarcomas as well as identified novel therapeutic targets and strategies based on gene profiling in osteosarcoma.

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、現在までに不明であったがんクリニカルシークエンスに基づいた骨軟部肉腫の治療適応可能遺伝子変化の頻度を明らかにした。骨肉腫にいては新規標的治療を同定しその適応対象が約40％の骨肉腫患者に存在することを明らかにした。特に染色体4q12領域のKIT、KDR、PDGFRA遺伝子、染色体6p12-21領域のVEGFA遺伝子の標的治療薬（阻害剤）は、臨床試験を経て新規治療法の開発へ繋がる可能性を大きく含んでおり、それらはゲノムベースアルゴリズムの基に理論的に薬剤を使用するがん個別化医療で展開することが可能となる 。

Research Products

• [Int'l Joint Research] Memorial Slaon-Kettering Cancer Center(米国) (2017)
  • Year and Date: 2017-04-01
• [Journal Article] Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations. (2019)
  • Author(s): Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Chakravarty D, Wang L, Jour G, Nafa K, Hayashi T, Jungbluth AA, Frosina D, Slotkin E, Shukla N, Meyers P, Healey J, Hameed M, Ladanyi M.
  • Journal Title: Clinical Cancer Research Volume: 25 Issue: 21 Pages: 6346-6356
  • DOI: 10.1158/1078-0432.ccr-18-4032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. (2019)
  • Author(s): Suehara Y, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Sano K, Hasegawa N, Miura Y, Akaike K, Kim Y, Takamochi K, Takahashi F, Ueno T, Kaneko K, Saito T.
  • Journal Title: Proteomics Clin Appl Volume: 13 Issue: 5 Pages: 1800147-1800147
  • DOI: 10.1002/prca.201800147
  • Peer Reviewed
• [Journal Article] Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter. (2019)
  • Author(s): Hasegawa N, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Okubo T, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H, Kohsaka S.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 20047-20047
  • DOI: 10.1038/s41598-019-56377-z
  • Peer Reviewed / Open Access
• [Journal Article] Single Patient Expanded Access制度を利用してLarotrectinibで治療を行ったNTRK融合遺伝子有する小児軟部肉腫の1例論文種類. (2019)
  • Author(s): 加藤 俊介, 藤村 純也, 野崎 由美, 山口 茂夫, 高木 辰哉, 林 大久生, 齋藤 剛, Henry Dahlia, Ku Nora, 末原 義之
  • Journal Title: 癌と化学療法 Volume: 46巻 Pages: 1595-1597
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin‐fixed paraffin‐embedded specimens (2019)
  • Author(s): Kohsaka Shinji、Tatsuno Kenji、Ueno Toshihide、et al.
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1464-1479
  • DOI: 10.1111/cas.13968
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan. (2019)
  • Author(s): Kato S, Hayashi T, Suehara Y, Hamanoue H, Yamanaka S, Ichikawa Y, Higurashi T, Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T.
  • Journal Title: Jpn J Clin Oncol Volume: 49(2) Issue: 2 Pages: 174-182
  • DOI: 10.1093/jjco/hyy173
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report. (2019)
  • Author(s): Kurihara T, Suehara Y, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: Human Pathology Case reports Volume: 16 Pages: 100288-100288
  • DOI: 10.1016/j.ehpc.2019.01.008
  • Peer Reviewed / Open Access
• [Journal Article] Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review (2019)
  • Author(s): Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Kudo T, Maruyama Y, Kaneko K, YaoT.
  • Journal Title: Human Pathology Case reports Volume: 16 Pages: 100288-100288
  • DOI: 10.1016/j.ehpc.2019.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. (2018)
  • Author(s): Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T.
  • Journal Title: Oncotarget Volume: 9(101) Issue: 101 Pages: 37509-37519
  • DOI: 10.18632/oncotarget.26493
  • Peer Reviewed / Open Access
• [Journal Article] PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. (2018)
  • Author(s): Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T.
  • Journal Title: Oncotarget Volume: 9(38) Issue: 38 Pages: 25206-25215
  • DOI: 10.18632/oncotarget.25392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. (2018)
  • Author(s): 1.Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T.
  • Journal Title: Hum Pathol Volume: 78 Pages: 79-88
  • DOI: 10.1016/j.humpath.2018.04.022
  • Peer Reviewed / Open Access
• [Journal Article] KCTD12 is negatively regulated by Kit in gastrointestinal stromal tumors. (2018)
  • Author(s): Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M1, Kim Y, Tanabe Y, Takagi T, Hayashi T, Mogushi K, Kaneko K, Yao T, Saito T.
  • Journal Title: Oncotarget Volume: 9(43) Issue: 43 Pages: 27016-27026
  • DOI: 10.18632/oncotarget.25469
  • Peer Reviewed / Open Access
• [Journal Article] IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. (2018)
  • Author(s): Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T.
  • Journal Title: Oncotarget Volume: 9(18) Issue: 18 Pages: 14428-14443
  • DOI: 10.18632/oncotarget.24467
  • Peer Reviewed / Open Access
• [Journal Article] Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40 (2018)
  • Author(s): Hayashi Takuo、Takamochi Kazuya、Yanai Yuka、Mitani Keiko、Tomita Hisashi、Mogushi Kaoru、Suehara Yoshiyuki、Takahashi Fumiyuki、Suzuki Kenji、Saito Tsuyoshi、Yao Takashi
  • Journal Title: Human Pathology Volume: S0046-8177 Pages: 30037-6
  • DOI: 10.1016/j.humpath.2018.01.023
  • Peer Reviewed / Open Access
• [Journal Article] Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion (2018)
  • Author(s): Kohsaka Shinji、Saito Tsuyoshi、Akaike Keisuke、Suehara Yoshiyuki、Hayashi Takuo、Takagi Tatsuya、Kaneko Kazuo、Ueno Toshihide、Kojima Shinya、Kohashi Ken-ichi、Mano Hiroyuki、Oda Yoshinao、Yao Takashi
  • Journal Title: Human Pathology Volume: 72 Pages: 167-173
  • DOI: 10.1016/j.humpath.2017.08.017
  • Peer Reviewed / Open Access
• [Journal Article] A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer (2017)
  • Author(s): Kohsaka Shinji、Nagano Masaaki、Ueno Toshihide、Suehara Yoshiyuki、Hayashi Takuo、Shimada Naoko、Takahashi Kazuhisa、Suzuki Kenji、Takamochi Kazuya、Takahashi Fumiyuki、Mano Hiroyuki
  • Journal Title: Science Translational Medicine Volume: 9 Issue: 416 Pages: 6566-6566
  • DOI: 10.1126/scitranslmed.aan6566
  • Peer Reviewed / Open Access
• [Journal Article] DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel (2017)
  • Author(s): Takamochi Kazuya、Takahashi Fumiyuki、Suehara Yoshiyuki、Sato Eiichi、Kohsaka Shinji、Hayashi Takuo、Kitano Shigehisa、Uneno Toshihide、Kojima Shinya、Takeuchi Kengo、Mano Hiroyuki、Suzuki Kenji
  • Journal Title: Lung cancer Volume: 110 Pages: 26-31
  • DOI: 10.1016/j.lungcan.2017.05.016
  • Peer Reviewed / Open Access
• [Journal Article] Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma (2017)
  • Author(s): Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S,Kobayashi E, Okubo T, Kohsaka S, Saito T, Kaneko K, Suehara Y.
  • Journal Title: PLoS One Volume: 12(9) Issue: 9 Pages: 0185321-0185321
  • DOI: 10.1371/journal.pone.0185321
  • Peer Reviewed / Open Access
• [Journal Article] Arterial Thoracic Outlet Syndrome (aTOS) and Cerebellar Infarction Following a Stress Fracture of the First Rib and Extensive Callus (2017)
  • Author(s): 7.Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K.
  • Journal Title: J Bone Joint Surg. Case Connector Volume: 3 Issue: 3 Pages: e64-e64
  • DOI: 10.2106/jbjs.cc.17.00001
  • Peer Reviewed
• [Journal Article] TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients. (2016)
  • Author(s): Saito T, Akaike K, Kurisaki A, Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T.
  • Journal Title: Molecular and Clinical Oncology. Volume: 4(1) Pages: 61-64
  • Peer Reviewed / Open Access
• [Journal Article] Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab. (2016)
  • Author(s): Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.
  • Journal Title: PLoS One Volume: 10 Issue: 2 Pages: e0148401-e0148401
  • DOI: 10.1371/journal.pone.0148401
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Expression of F-actin-capping protein subunit beta is associated with cell growth and motility in epithelioid sarcoma. (2016)
  • Author(s): Mukaihara K, Suehara Y*, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi, M, Kaneko K, Saito T.
  • Journal Title: BMC cancer. Volume: 16(1) Issue: 1 Pages: 206-206
  • DOI: 10.1186/s12885-016-2235-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys. (2016)
  • Author(s): Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research. Volume: 15(9) Issue: 9 Pages: 1-9
  • DOI: 10.9734/bjmmr/2016/26127
  • Peer Reviewed / Open Access
• [Journal Article] Paget's sarcoma with sarcoma-specific TP53 mutation arising from a Japanese patient. (2016)
  • Author(s): Akaike K, Toda-Ishii M, Suehara Y, Takagi T, Kaneko K,Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 9(3) Pages: 3978-3986
  • Peer Reviewed / Open Access
• [Journal Article] Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy: (2016)
  • Author(s): Suehara Y*, Osawa H, Kubota D, Kato S, Akaike K, Tanabe Y, Saito T, Kaneko K.
  • Journal Title: J Bone Joint Surg Volume: 6 (3) Issue: 3 Pages: e70-e70
  • DOI: 10.2106/jbjs.cc.15.00281
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors (2016)
  • Author(s): Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: Modern Pathology. Volume: 29 Issue: 11 Pages: 1424-1432
  • DOI: 10.1038/modpathol.2016.138
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced argininosuccinate synthetase expression in refractory sarcomas. (2016)
  • Author(s): Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S.
  • Journal Title: Oncotarget. Volume: 7(43) Issue: 43 Pages: 70832-70844
  • DOI: 10.18632/oncotarget.12225
  • Peer Reviewed / Open Access
• [Journal Article] A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis (2016)
  • Author(s): Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Akaike K, Miura K, Kato S.
  • Journal Title: Int Canc Conf J. Volume: 5(4) Issue: 4 Pages: 192-196
  • DOI: 10.1007/s13691-016-0256-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey. (2016)
  • Author(s): Kim Y, Suehara Y, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K.
  • Journal Title: British Journal of Medicine & Medical Research. Volume: 17(5) Pages: 1-13
  • Peer Reviewed / Open Access
• [Journal Article] A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia. (2016)
  • Author(s): Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 9(7) Pages: 7230-7236
  • Peer Reviewed / Open Access
• [Journal Article] A case of epithelioid hemangioma of the right third rib in a 55-year-old man. (2016)
  • Author(s): Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T.
  • Journal Title: International journal of clinical and experimental pathology. Volume: 9(9) Pages: 9681-9686
  • Peer Reviewed / Open Access
• [Presentation] Clinical genomic sequencing revealed potentially actionable alterations in osteosarcomas (2019)
  • Author(s): Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Wang L, Jour G, Meyers P, Healey J, Hameed M, Ladanyi M.
  • Organizer: 2nd International Combined Meeting of Orthopaedic Research Societies
  • Int'l Joint Research / Invited
• [Presentation] Larotrectinib as neoadjuvant therapy in the treatment of pediatric Tropomyosin Receptor Kinase fusion sarcomas. (2019)
  • Author(s): Bielack S, Geoerger B, Dubois S, Mascarenhas L, Nagasubramanian R, Pappo A, Turpin B, Ghosh T, Kirby M, Saito S, Ziegler D, Suehara Y, Shukla N, Childs B, Ku N, Cox M, Laetsch T. Federman N.
  • Organizer: 32nd annual Meeting of the European Musculo Skeletal Oncology Society.
  • Int'l Joint Research
• [Presentation] Integrative analysis including whole genome sequencing, transcriptome sequencing, and phospho-protein expression profiling of super responder to pazopanib in high-grade soft tissue sarcomas. (2019)
  • Author(s): Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Kaneko K , Kato S, Mano H, Saito T.
  • Organizer: 20th International Symposium on Limb Salvage
  • Int'l Joint Research
• [Presentation] 教育研修講演：骨・軟部腫瘍における精密医療開発・新規分子標的開発の役割 (2019)
  • Author(s): 末原 義之
  • Organizer: 52回日本整形外科学会骨・軟部腫瘍学術集会
  • Invited
• [Presentation] シンポジウム：骨・軟部腫瘍のゲノム医療とカウンセリング_軟部肉腫のTyrosine kinase融合遺伝子・遺伝子変異体の探索 (2019)
  • Author(s): 末原 義之, 高阪 真路, 栗崎 愛子, 林 大久生, 赤池 慶祐, 佐藤 信吾, 小林 英介, 金子 和夫, 間野 博行, 齋藤 剛
  • Organizer: 52回日本整形外科学会骨・軟部腫瘍学術集会
  • Invited
• [Presentation] Clinicopathological characteristics of lung adenocarcinoma with EGFR compound mutations. (2019)
  • Author(s): Hayashi T, Kohsaka S, Takamochi K, Takahashi F, Suehara Y, SaitoT, Suzuki K, Mano H, Yao T.
  • Organizer: USCAP, the 2019 Annual Meeting
  • Int'l Joint Research
• [Presentation] Metabolic fluctuations in adriamycin-resistant osteosarcomas using metabolomic approaches (2019)
  • Author(s): Sasa K, Suehara Y, Akaike K, Hayashi T, Taka H, Youngji K, Okubo T, Kaneko K, Saito T.
  • Organizer: the 65th Annual Meeting of the Orthopaedic Research Society
  • Int'l Joint Research
• [Presentation] IRE1α-XBP1 Inhibitor exerts antiyumor activity in osteosarcoma. (2019)
  • Author(s): Kurihara T, Suehara Y, Hayashi T, Akaike K, Okubo T, Kim Y, Kaneko K, Saito T.
  • Organizer: the 65th Annual Meeting of the Orthopaedic Research Society
  • Int'l Joint Research
• [Presentation] Comprehensive mRNA-based screen for tyrosine kinase fusions and a de novo alternative transcription initiation site in soft tissue sarcomas. (2018)
  • Author(s): Suehara Y, Kohsaka S, Kurisaki A, Akaike K, Hayashi T, Mogushi K, Okubo T, Kim Y, Sato S, Kobayashi E, Kaneko K, Mano H, Saito T.
  • Organizer: European Society For Medical Oncology ASIA
  • Int'l Joint Research
• [Presentation] IRE1α-XBP1 Inhibitor exerts antiyumor activity in osteosarcoma. (2018)
  • Author(s): Kurihara T, Suehara Y, Hayashi T, Akaike K, Okubo T, Kim Y, Kaneko K, Saito T.
  • Organizer: Connective Tissue Oncology Society, 23th Annual Meeting
  • Int'l Joint Research
• [Presentation] Expanded access of larotrectenib to manage pediatric TRK fusion sarcomas. (2018)
  • Author(s): Suehara Y, Trahair T, Kirby M, Saito S, Capra M, Ghosh T, Henry D, Ku NC, Cox MC, Kato S, Ziegler DS.
  • Organizer: 50th Congress of International Society of Paediatric Oncology,
  • Int'l Joint Research
• [Presentation] Clinical genomic sequencing of 72 pediatric and adult osteosarcomas reveals distinct molecular subsets with potentially targetable alterations. (2018)
  • Author(s): Alex D, Suehara Y, Bowman A, Middha S, Zehir A, Wang L, Jour G, Nafa K, Meyers P, Healey J, Hameed M, Ladanyi M.
  • Organizer: USCAP, the 2018 Annual Meeting, 2018
  • Int'l Joint Research
• [Presentation] 骨軟部腫瘍のプレシジョンメディシンの可能性 (2017)
  • Author(s): 末原義之
  • Organizer: 第53回 Kyoto Orthopaedic Seminar 2017年12月12日 京都大学 京都市
  • Invited
• [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み (2017)
  • Author(s): 末原 義之、林 大久生、山口茂夫、齋藤 剛、 Marc Ladanyi、加藤 俊
  • Organizer: 第32回日本整形外科学会基礎学術集会 2017年10月26-27日 沖縄コンベンションセンター 那覇市 沖縄県
• [Presentation] 軟部肉腫Pazopanib著効例における分子病理学的探索 (2017)
  • Author(s): 末原義之、高阪真路、赤池慶祐、加藤俊介、林大久生、山口茂夫、田邊雄、窪田大介、高木辰哉、金子和夫、間野博行、齋藤剛
  • Organizer: 第32回日本整形外科学会基礎学術集会 2017年10月26-27日 沖縄コンベンションセンター 那覇市 沖縄県
  • Invited
• [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み (2017)
  • Author(s): 末原 義之、林 大久生、山口茂夫、齋藤 剛、Marc Ladanyi、加藤 俊介
  • Organizer: 骨軟部腫瘍の基礎を語る会2017 2017年10月26日 沖縄コンベンションセンター 那覇市 沖縄県
  • Invited
• [Presentation] 順天堂医院におけるクリニカルシークエンスMSK-IMPACT検査の導入経験 (2017)
  • Author(s): 加藤俊介、末原義之、林大久生、斉藤剛、山口茂夫、野崎由美
  • Organizer: ５５回日本癌治療学会学術集会 2017年10月20-22日 パシフィコ横浜、横浜
• [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み (2017)
  • Author(s): 末原 義之、林 大久生、山口茂夫、赤池慶祐、窪田大介、 高木辰哉、金子和夫、齋藤 剛、Marc Ladanyi 、加藤 俊介
  • Organizer: 第15回関東骨軟部腫瘍の基礎を語る会 2017年10月7日、国立がん研究センター研究、東京
• [Presentation] 骨肉腫のがんクリニカルシークエンス (2017)
  • Author(s): 末原義之、Deepu Alex、Anita Bowman、Sumit Middha、 Ahmet Zehir、Lu Wang、Paul Meyers 、John Healey、Meera Hameed、Marc Ladanyi
  • Organizer: 第15回関東骨軟部腫瘍の基礎を語る会 2017年10月7日、国立がん研究センター研究、東京
• [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み (2017)
  • Author(s): 山口茂夫、加藤俊介、野崎由美、茂櫛薫、末原義之、高坂真路、斉藤剛、林大久生
  • Organizer: 第17回日本臨床腫瘍学会 2017年7月18-20日 国立京都国際会館、京都
• [Presentation] 順天堂医院におけるがんクリニカルシークエンスMSK-IMPACTの試み (2017)
  • Author(s): 末原 義之、林 大久生、高阪 真路、山口茂夫、齋藤 剛、Marc Ladanyi、加藤 俊介
  • Organizer: 第50回日本整形外科学会骨軟部腫瘍学術集会 2017年7月13-14日 京王プラザホテル 新宿 東京
• [Presentation] 低悪性軟部肉腫に新規融合遺伝子(LMNA-NTRK1)を有した１例 (2017)
  • Author(s): 末原義之、高阪真路、赤池慶祐、林大久生、田邊雄、大久保武人、窪田大介、高木辰哉、金子和夫、間野博行、齋藤剛
  • Organizer: 第50回日本整形外科学会骨軟部腫瘍学術集会 2017年7月13-14日 京王プラザホテル 新宿 東京
• [Presentation] 軟部肉腫Pazopanib著効例 “super-responder”に基づいた分子病理学的探索 (2017)
  • Author(s): 末原義之、高阪真路、赤池慶祐、加藤俊介、林大久生、山口茂夫、田邊雄、窪田大介、高木辰哉、金子和夫、間野博行、齋藤剛
  • Organizer: 第50回日本整形外科学会骨軟部腫瘍学術集会 2017年7月13-14日 京王プラザホテル 新宿 東京
• [Presentation] 順天堂医院病理診断部におけるMSK-IMPACTの試み (2017)
  • Author(s): 林 大久生、齋藤 剛、末原 義之、高阪 真路、園上 浩司、寺尾 暁子、福村 由紀、荒川 敦、加藤 俊介、八尾 隆史
  • Organizer: 106回日本病理学会総会 2017年4月27-29日 京王プラザホテル 新宿 東京
• [Presentation] The Regulation of Malignant Transformation by PPP2R1A in Alveolar Rhabdomyosarcoma Based On A Proteomic Approach Corresponding To The PAX3/FOXO1 Fusion Gene. (2016)
  • Author(s): Akaike K, Suehara Y, Kohsaka S, Mukaihara K, Ishii M, Kubota D, Tanabe Y, Kazuno S, Mineki R, Fujimura T, Kaneko K, Ladanyi M, Saito T.
  • Organizer: Connective Tissue Oncology Society, 21th Annual Meeting,
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Proteomic approaches revealed inhibition of IRE1/XBP1 pathway reduces tumor growths in Ewing's sarcomas. (2016)
  • Author(s): Tanabe Y, Suehara Y, Kohsaka S, Mukaihara K, Kubota D, Akaike K, Ishii M, Kazuno S, Mineki R, Kaneko K, Ladanyi M, Saito T.
  • Organizer: Connective Tissue Oncology Society, 21th Annual Meeting,
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Book] 新しい医療技術 プレシジョンメディシンによる骨肉腫の新規治療標的 (2020)
  • Author(s): 末原 義之, Ladanyi Marc
  • Total Pages: 2
  • Publisher: 整形・災害外科
• [Book] 肉腫治療の最前線】肉腫のがんクリニカルシークエンス (2019)
  • Author(s): 末原義之、Marc Ladanyi
  • Total Pages: 5
  • Publisher: 医学のあゆみ