Manipulation of blood lactate concentration against obesity(Fostering Joint International Research)
| Project/Area Number |
15KK0358
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Research Collaborator |
Secher Niels H. コペンハーゲン大学, Muscle Research Centre, Professor
Bailey Damian 南ウェールズ大学, Life Science and Education, Professor
Costello Joseph ポーツマス大学, Sport and Exercise Science, Senior Lecture
Lim Kiwon 建国大学, Physical Education, Professor
Brothers Robert テキサス大学, Department of Kinesiology, Associate Professor
Hall Gerrit van
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| Project Period (FY) |
2015 – 2018
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 認知機能 / 運動 / サプリメント / 加齢 / 筋肥大 / サルコペニア / 代謝疾患 / 肥満 / 脳内代謝 / 高強度間欠的運動 / 実行機能 / 乳酸 / 動静脈較差 / メタボローム / 低酸素 / スポーツ健康科学 / 脳機能 / 筋萎縮 |
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| Outline of Final Research Achievements |
I have been focusing on the lactate metabolism, and found that it functions as an inducer of cell signaling in skeletal muscle cells and adipocytes. Furthermore, lactate is an important substrate for our organs including brain. The aim of this study was to examine whether manipulation of blood lactate concentration can be a therapeutic strategy against aging, particularly by supporting exercise-induced enhancement of cognitive function. I found that lactate produced by working muscle might be a pivotal factor for exercise-induced enhancement of cognitive function. The finding suggests that lactate may be a beneficial molecule against aging to elicit a metabolic interaction between skeletal muscle, adipose tissue, and brain.
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| Academic Significance and Societal Importance of the Research Achievements |
健康増進に対する運動効果は周知の事実であるが、そのメカニズムは多面的である。その中で、運動（特に高強度の運動）誘発性の乳酸が運動効果の分子機序の一つとして機能し、認知機能にも影響することを明らかにした。このことは、特に乳酸産生を促すような運動の有用性を示唆するとともに、サプリメントなど、外的に乳酸を付加することの有用性も示唆しており、広く万人に有効なアンチエイジングに繋がる知見を提供し得た。
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Flavanol-rich cocoa consumption enhances exercise-induced executive function improvements in humans2018
Author(s)
Tsukamoto H, Suga T, Ishibashi A, Takenaka S, Tanaka D, Hirano Y, Hamaoka T, Goto K, Ebi K, Isaka T, and Hashimoto T
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Journal Title
Nutrition
Volume: 46
Pages: 90-96
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Relationship of brain lactate uptake, cerebral hemodynamics, and executive function after high intensity interval exercise in humans2017
Author(s)
Tsukamoto H, Olesen N.D., Petersen L.G., Sorensen H, Nielsen H.B., Secher N.H., Ogoh S, Hashimoto T
Organizer
28th Symposium on Cerebral Blood Flow, Metabolism and Function & 13th Conference on Quantification of Brain Function with PET
Related Report
Int'l Joint Research
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[Presentation] 生体内における乳酸の役割2016
Author(s)
橋本健志
Organizer
第16回日本抗加齢医学会総会
Place of Presentation
パシフィコ横浜会議センター（神奈川県、横浜市）
Year and Date
2016-06-10
Related Report
Invited
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[Presentation] Dynamics of the Carotid Baroreflex Function at the Onset of Leg Cycling2016
Author(s)
Thales C. Barbosa, Lauro C. Vianna, Takeshi Hashimoto, Lonnie G. Petersen, Niels D. Olesen, Hayato Tsukamoto, Henrik Sorensen, Shigehiko Ogoh, Antonio C. L. Nobrega, Niels H. Secher
Organizer
Experimental Biology
Place of Presentation
San Diego, USA
Year and Date
2016-04-05
Related Report
Int'l Joint Research
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