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Development of a Nonlinear Timeseries Analysis for Functional Neural Connectivity Estimation

Research Project

Project/Area Number 15KT0013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Mathematical Sciences in Search of New Cooperation
Research InstitutionJapan Advanced Institute of Science and Technology

Principal Investigator

Hidaka Shohei  北陸先端科学技術大学院大学, 先端科学技術研究科, 准教授 (50582912)

Co-Investigator(Kenkyū-buntansha) ディブレクト マシュー  京都大学, 人間・環境学研究科, 特定講師 (20623599)
高田 美絵子 (森島美絵子)  生理学研究所, 基盤神経科学研究領域, 助教 (30435531)
平 理一郎  基礎生物学研究所, 大学共同利用機関等の部局等, 助教 (80712299)
Project Period (FY) 2015-07-10 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywordsカルシウムイメージング / コネクトミクス / 計算神経科学 / データサイエンス / 情報理論 / 非線形力学系
Outline of Final Research Achievements

Cortex plays important roles in higher order functions as well as perception, motor control, and emotion. Previous studies have reported microscopic findings on individual structure of neural circuits and macroscopic findings on activities in a particular brain area correlated with a class of tasks. It is, however, largely unknown on the meso-scopic scale or the intermediate level connecting both. This study has developed a new information technique for estimating the functional neural connectivity from the timeseries data obtained by the Ca imaging method. We validated the developed technique with both empirical and simulated datasets, and showed that it could detect a set of sub-groups of neurons with dense functional connectivity.

Academic Significance and Societal Importance of the Research Achievements

脳の情報処理の解明には、個々の神経細胞や、マクロレベルをつなぐ、メゾレベルの神経結合の理解が不可欠である。将来的に数千~数万のオーダーへの発展が予想されるCaイメージング法から得られるデータを解析し、機能的神経結合を推定することで数万単位の神経細胞の集団的な計算処理の全体像が明確に記述できる。こうした考えに基づき、大規模な神経ネットワークの情報構造の推定方法の開発を行った。本研究で開発した解析法では1000程度の神経細胞の時系列から、機能的に密な結合をもつ神経細胞のサブ集団を検出できることが確認された。この成果は、大脳皮質の中間スケールの情報構造の解明に寄与すると考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (31 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (14 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results) Remarks (5 results)

  • [Int'l Joint Research] カリフォルニア大学サンタバーバラ校(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A Representation of Rhythmic Motions2019

    • Author(s)
      Fujinami Tsutomu、Hidaka Shohei
    • Journal Title

      New Generation Computing

      Volume: 37 Issue: 2 Pages: 185-201

    • DOI

      10.1007/s00354-019-00051-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fast and exact search for the partition with minimal information loss2018

    • Author(s)
      Hidaka Shohei、Oizumi Masafumi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 9 Pages: 0201126-0201126

    • DOI

      10.1371/journal.pone.0201126

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経細胞の情報論的結合を推定する非線形時系列解析法2018

    • Author(s)
      日髙 昇平 & 平 理一郎
    • Journal Title

      細胞

      Volume: 50 Pages: 755-758

    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences.2018

    • Author(s)
      Arielle Baker, Brian Kalmbach, Mieko Morishima, Juhyun Kim, Ashley Juavinett, Nuo Li, and Nikolai Dembrow
    • Journal Title

      Journal of Neuroscience

      Volume: 未定

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mice use robust and common strategies to discriminate natural scenes2018

    • Author(s)
      Yu, Y., Hira, R., Stirman, J. N., Yu, W., Smith, I. T., & Smith, S. L.
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1379-1379

    • DOI

      10.1038/s41598-017-19108-w

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Segregated Excitatory?Inhibitory Recurrent Subnetworks in Layer 5 of the Rat Frontal Cortex2017

    • Author(s)
      Morishima Mieko、Kobayashi Kenta、Kato Shigeki、Kobayashi Kazuto、Kawaguchi Yasuo
    • Journal Title

      Cerebral Cortex

      Volume: 27 Issue: 12 Pages: 5846-5857

    • DOI

      10.1093/cercor/bhx276

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 最適化を超えた認知科学の新たなパラダイムに向けて:Marrの情報処理の三水準の再考2017

    • Author(s)
      日高 昇平
    • Journal Title

      認知科学

      Volume: 24 Pages: 67-78

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Cognitive Loading on Postural Control in Parkinson's Disease with Freezing of Gait.2016

    • Author(s)
      Buated, W., Lolekha, P., Hidaka, S., & Fujinami, T.
    • Journal Title

      Gerontology and Geriatric Medicine

      Volume: 2 Pages: 1-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] From Transmission to Understanding of Information2016

    • Author(s)
      日高 昇平.
    • Journal Title

      Transactions of the Japanese Society for Artificial Intelligence

      Volume: 31 Issue: 6 Pages: AI30-H_1-10

    • DOI

      10.1527/tjsai.AI30-H

    • NAID

      130005277068

    • ISSN
      1346-0714, 1346-8030
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動野内に見られる異なる運動パターンの局在2016

    • Author(s)
      平 理一郎、松崎 政紀
    • Journal Title

      Clinical Neuroscience

      Volume: 34

    • Related Report
      2015 Research-status Report
  • [Journal Article] 読書時の身体情報による熱中度変化の記述2016

    • Author(s)
      布山 美慕,日高 昇平
    • Journal Title

      認知科学

      Volume: 23

    • NAID

      130005171082

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimating the latent number of types in growing corpora with reduced cost–accuracy trade-off.2016

    • Author(s)
      Hidaka, S.
    • Journal Title

      Journal of Child Language

      Volume: 43 Pages: 107-134

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct functional modules for discrete and rhythmic forelimb movements in the mouse motor cortex.2015

    • Author(s)
      Hira, R., Terada, S-I., Kondo, M., Matsuzaki, M.
    • Journal Title

      The Journal of Neuroscience

      Volume: 35 Pages: 13311-13322

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 利己的な学習による相互協調:不確実な囚人のジレンマの分析2015

    • Author(s)
      鳥居拓馬 & 日高昇平
    • Journal Title

      認知科学

      Volume: 22 Pages: 341-355

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Interaction between GABAergic cells and projection specific pyramidal cells in the layer 5 of rat frontal cortex2017

    • Author(s)
      M. Morishima
    • Organizer
      47th annual meeting of the Society for Neuroscience mini symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Interaction between GABAergic cells and two types of target-specific pyramidal cells in layer 5 of the rat frontal cortex2016

    • Author(s)
      Morishima M, Kawaguchi Y
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 情報理論から意味理解の理論へ2016

    • Author(s)
      日高 昇平
    • Organizer
      第30回人工知能学会全国大会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2016-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 重心運動を指標としたパーキンソン病の潜在リスクの推定2016

    • Author(s)
      日高 昇平, Wannipat Buated, & 藤波 努
    • Organizer
      第22回身体知研究会
    • Place of Presentation
      しいのき迎賓館(石川県金沢市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Toward a mechanistic account for imitation learning: an analysis of pendulum swing-up2016

    • Author(s)
      Torii, T. & Hidaka, S.
    • Organizer
      The Third International Workshop on Skill Science.
    • Place of Presentation
      Raiosha Building, Keio University Kanagawa, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 覚醒脳の高次元神経活動の記録と解析2015

    • Author(s)
      平理一郎
    • Organizer
      分子科学研究所オープンセミナー
    • Place of Presentation
      自然科学研究機構 分子科学研究所(愛知県岡崎市)
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Distinct thalamocortical activities in the motor cortex during voluntary movements2015

    • Author(s)
      Y. H. Tanaka, Y. R. Tanaka, R. Hira, M. Kondo, S. Terada, Y. Kawaguchi, M. Matsuzaki.
    • Organizer
      Society of Neuroscience
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 注視から認知過程へ:認知発達研究におけるベイズ統計モデリング2015

    • Author(s)
      日高 昇平
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-09-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 身体動作の解読:力学的な不変量による分節化2015

    • Author(s)
      日高昇平
    • Organizer
      日本認知科学会
    • Place of Presentation
      千葉大学(千葉県千葉市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Multi-compartmental models of corticopontine- and crossed corticostriatal neurons of rat frontal cortex2015

    • Author(s)
      Masashi Kondo, Mieko Morishima, Yasuo Kawaguchi, Kenji Morita
    • Organizer
      11th Bernstein Conference 2015
    • Place of Presentation
      Heidelberg (Germany)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
  • [Book] 科学と文化をつなぐアナロジーという思考様式.2016

    • Author(s)
      平理一郎
    • Total Pages
      364
    • Publisher
      東京大学出版会
    • Related Report
      2015 Research-status Report
  • [Remarks] Cognitive Computation Lab

    • URL

      http://www.jaist.ac.jp/ks/labs/shhidaka/cogcomp/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Remarks] 認知計算論

    • URL

      http://www.jaist.ac.jp/~shhidaka/

    • Related Report
      2016 Research-status Report
  • [Remarks] 認知システム研究 Cognitive System Research

    • URL

      http://www.jaist.ac.jp/~shhidaka/

    • Related Report
      2015 Research-status Report
  • [Remarks] Matthew de Brecht, Ph. D.

    • URL

      http://www.cns.atr.jp/~matthew/

    • Related Report
      2015 Research-status Report
  • [Remarks] 森島 美絵子

    • URL

      http://www.nips.ac.jp/research/researcher/assist/post_82.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-07-14   Modified: 2020-03-30  

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