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Chemical genetic approach toward eradication of noxious parasitic weed Striga hermonthica

Research Project

Project/Area Number 15KT0031
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Food Cycle Research
Research InstitutionNagoya University

Principal Investigator

Tsuchiya Yuichiro  名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 (00442989)

Co-Investigator(Renkei-kenkyūsha) URAGUCHI Daisuke  名古屋大学, 工学研究科, 准教授 (70426328)
Research Collaborator KUWATA Keiko  
SATO Ayato  
Project Period (FY) 2015-07-10 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsストリゴラクトン / 植物ホルモン / 寄生植物 / ストライガ / 食料問題 / 自殺発芽 / ストリゴラクトン受容体 / ケミカルバイオロジー / 食糧問題
Outline of Final Research Achievements

A nixious parasitic plant called Striga hermonthica (Striga) represents a major threat to food security in Africa. In this research project, I focused on a host-depent germination mechanism in Striga and use it to develop a specific herbicide that lead the seeds to "suicide germination". The developed molecule (code name : SAMR690), which is composed of synthetic scaffold connected with the active core structure of strigolactones, exhibits extraordinary potency in stimulating Striga germination at femto-molar range without impinging on beneficial functions in the host strigolactone-related processes. Most importantly, the three-step procedure for synthesizing SAMO-Me-690 greatly increases the potential for Striga eradication via suicide germination campaigns in Africa.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 9 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Toronto(Canada)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Department of Cell and Systems Biology/University of Toronto(Canada)

    • Related Report
      2015 Research-status Report
  • [Journal Article] The dynamics of strigolactone perception in Striga hermonthica: a working hypothesis2018

    • Author(s)
      Tsuchiya Yuichiro、Yoshimura Masahiko、Hagihara Shinya
    • Journal Title

      Journal of Experimental Botany

      Volume: 69 Issue: 9 Pages: 2281-2290

    • DOI

      10.1093/jxb/ery061

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perception of strigolactones by parasitic plant <i>Striga</i>2017

    • Author(s)
      土屋 雄一朗
    • Journal Title

      Regulation of Plant Growth & Development

      Volume: 52 Issue: 2 Pages: 63-69

    • DOI

      10.18978/jscrp.52.2_63

    • NAID

      130006308100

    • ISSN
      1346-5406, 2189-6305
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Small-molecule antagonists of germination of the parasitic plant Striga hermonthica.2016

    • Author(s)
      Holbrook-Smith D, Toh S, Tsuchiya Y, McCourt P
    • Journal Title

      Nature Chemical Biology

      Volume: 12 Issue: 9 Pages: 724-729

    • DOI

      10.1038/nchembio.2129

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Probing strigolactone receptors in Striga hermonthica with fluorescence.2015

    • Author(s)
      Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
    • Journal Title

      Science

      Volume: 349 Issue: 6250 Pages: 864-869

    • DOI

      10.1126/science.aab3831

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure-function analysis identifies highly sensitive strigolactone receptors in Striga.2015

    • Author(s)
      Toh, S., Holbrook-Smith, D., Stogios, P.J., Onopriyenko, O., Lumba, S., Tsuchiya, Y., Savchenko, A., and McCourt, P.
    • Journal Title

      Science

      Volume: 350 Issue: 6257 Pages: 203-207

    • DOI

      10.1126/science.aac9476

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Femto-molar stimulants for seed germination in a parasitic plant Striga2018

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      第59回日本植物生理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A synthetic stimulant for seed germination in a parasitic plant Striga2017

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      2nd International Congress on Strigolactones
    • Place of Presentation
      Trino, Italy
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2017

    • Author(s)
      Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
    • Organizer
      2nd Edition of the International Congress on Strigolactones
    • Place of Presentation
      Trino, Italy
    • Year and Date
      2017-03-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A synthetic stimulant for seed germination in a parasitic plant Striga2017

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      日本植物生理学会年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chemical Biology to combat against a parasitic plant Striga2017

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      5th Annual South Asia Biosafety Conference (SABC)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 寄生植物ストライガの撲滅に向けた化学と生物の融合研究2017

    • Author(s)
      土屋 雄一朗
    • Organizer
      天然物化学談話会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2017

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      2nd Edition of the International Congress on Strigolactones (ICS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 寄生植物ストライガの発芽を制御する人工アゴニストの開発2017

    • Author(s)
      土屋 雄一朗
    • Organizer
      日本農芸化学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A synthetic stimulant for seed germination in a parasitic plant Striga2017

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      日本農芸化学会年会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence2016

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      International conference on plant growth substances (IPGSA)
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-06-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2016

    • Author(s)
      Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
    • Organizer
      The International Plant Growth Substances Association Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2016-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] Yuichiro Tsuchiya

    • URL

      http://www.itbm.nagoya-u.ac.jp/en/members/y-tsuchiya/

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 寄生植物発芽調節剤2017

    • Inventor(s)
      土屋雄一朗、浦口大輔、大井貴史、木下俊則、桑田啓子
    • Industrial Property Rights Holder
      土屋雄一朗、浦口大輔、大井貴史、木下俊則、桑田啓子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-07-14   Modified: 2019-03-29  

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