| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Outline of Final Research Achievements |
Chiral metal nanoparticle catalysts of bifunctional chiral ligand and Rh-Ag nanoparticles mediate asymmetric 1,4-addition of aryl boronic acid to unsaturated carbonyl compounds in high yield and enantioselectivity. We hypothesized that the diene structure of the ligand construct asymmetric environment through interaction with active metal species and the secondary amide moiety places substrate in appropriate position in the reaction environment through hydrogen bonding. According to kinetic studies, XPS analysis, SR-MAS NMR analysis, and non-linear effect analysis provided various information about the active metal species, fashion of interaction between active metal species and chiral ligand, and transition states of intermediates in the catalytic cycles.
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