| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
|---|
| Outline of Final Research Achievements |
Catalytic reactions using neighboring effect for efficient bond formation were developed. First, a reaction for direct construction of fused carbazoles by a gold-catalyzed cascade cyclization of conjugated diynes bearing an azide group was developed. This reaction was applied to total synthesis of dictyodendrins and their structure-activity relationship study. Next, efficient construction of the tetracyclic indoline scaffold of akuammiline alkaloids was developed, which was useful for formal total synthesis of strictamine. Gold-catalyzed cascade cyclization reactions of skipped diynes and 1,4-diyn-3-ones were also developed. These results clearly demonstrate that the neighboring effect in gold-catalyzed alkyne activation is extremely useful in syntheses of diverse heterocycles.
|
