| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
|---|
| Outline of Final Research Achievements |
This study aimed to clarify the differences between biomembranes and artificial (proteo)liposomes, in order to build biomembranes. The differences include some points that membrane proteins spontaneously and disorderly insert into liposomes (1) and that the physical strength and resistance against chemical compounds in liposomes are significantly weaker than those in biomembranes. We clarified the molecular mechanisms underlying the blockage of spontaneous insertion by diacylglycerols and cholesterols, which was confirmed by computer-simulation analysis. Moreover, we identified a membrane component that gives the physical strength and resistance against chemical compounds to biomembranes. The structure determination the compound is on progress.
|
